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Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.

Abstract：

:Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Caldirola P,Chowdhury R,Unelius L,Mohell N,Hacksell U,Johansson AM

doi

10.1016/s0960-894x(99)00232-2

subject

Has Abstract

pub_date

1999-06-07 00:00:00

pages

1583-6

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960894X99002322

journal_volume

9

pub_type

杂志文章

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