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Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.

Abstract：

:Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Maillard LT,Bertout S,Quinonéro O,Akalin G,Turan-Zitouni G,Fulcrand P,Demirci F,Martinez J,Masurier N

doi

10.1016/j.bmcl.2013.01.039

subject

Has Abstract

pub_date

2013-03-15 00:00:00

pages

1803-7

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00072-3

journal_volume

23

pub_type

杂志文章

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