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Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systems.

Abstract：

:Synthesis and characterization of an inert perchlorotriphenylmethyl triester radical, PTM-TE, are reported. PTM-TE was prepared by a facile 3-step synthesis using Friedel-Crafts reaction of tetrachlorobenzene with chloroform followed by ethoxycarbonylation and subsequent oxidation. PTM-TE is paramagnetic and exhibits a single sharp EPR spectrum. In solution, the EPR linewidth of PTM-TE is highly sensitive to the dissolved oxygen content, thus enabling accurate measurement of oxygen concentration (oximetry). In addition, the radical also shows high reactivity towards superoxide. The ester radical has the potential for use as a high-sensitive probe for determination of oxygen concentration and superoxide in biological systems.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dang V,Wang J,Feng S,Buron C,Villamena FA,Wang PG,Kuppusamy P

doi

10.1016/j.bmcl.2007.04.070

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

4062-5

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00502-1

journal_volume

17

pub_type

杂志文章

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