Structure-activity relationships of novel potent MurF inhibitors.

Abstract:

:A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.

journal_name

Bioorg Med Chem Lett

authors

Gu YG,Florjancic AS,Clark RF,Zhang T,Cooper CS,Anderson DD,Lerner CG,McCall JO,Cai Y,Black-Schaefer CL,Stamper GF,Hajduk PJ,Beutel BA

doi

10.1016/j.bmcl.2003.09.073

subject

Has Abstract

pub_date

2004-01-05 00:00:00

pages

267-70

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960894X03010655

journal_volume

14

pub_type

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