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Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives.

Abstract：

:Horner-Emmons reaction of 4"-dehydro-5-O-TBDMS-avermectin B(1a) with a variety of phosphorus ylides using LHMDS gave novel 4"-alkylidene avermectin derivatives in high yields. Further modifications led to derivatives bearing diverse functional groups. The new avermectin derivatives showed potent growth inhibitory activity against Artemia salina and Caenorhabditis elegans.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nagai K,Sunazuka T,Shiomi K,Harder A,Turberg A,Omura S

doi

10.1016/j.bmcl.2003.09.003

subject

Has Abstract

pub_date

2003-11-17 00:00:00

pages

3943-6

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960894X03009478

journal_volume

13

pub_type

杂志文章

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