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Diaminopyrimidine and diaminopyridine 5-HT7 ligands.

Abstract：

:The present studies have identified a series of diaminopyrimidines and diaminopyridines as novel 5-HT(7) receptor ligands. Three regiosiomeric classes of pyrimidines and four regioisomeric classes of pyridines were synthesized and analyzed for binding to the 5-HT(7) receptor. The 5-HT(7) binding affinities of different regioisomers show clearly the structure-activity relationship with position of ring nitrogens.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Denhart DJ,Purandare AV,Catt JD,King HD,Gao A,Deskus JA,Poss MA,Stark AD,Torrente JR,Johnson G,Mattson RJ

doi

10.1016/j.bmcl.2004.06.007

subject

Has Abstract

pub_date

2004-08-16 00:00:00

pages

4249-52

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960894X04007486

journal_volume

14

pub_type

杂志文章

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