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Synthesis of a bis-azido analogue of acromelic acid for radioisotope-free photoaffinity labeling and biochemical studies.

Abstract：

:A novel acromelic acid analogue containing a phenyl group possessing two different types of azido functional groups, of which one is the aromatic N3 acting as a photoaffinity group to bind to a target protein by photoirradiation and the other is alkyl N3 group which survives photolysis acting as a detecting group through the Staudinger-Bertozzi reaction to identify the ligated product, was designed and synthesized as a radioisotope-free biochemical probe potentially for studies on kainoid receptors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sun P,Wang GX,Furuta K,Suzuki M

doi

10.1016/j.bmcl.2006.01.083

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

2433-6

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00130-2

journal_volume

16

pub_type

杂志文章

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