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The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.

Abstract：

:Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these tools allowed for a thorough evaluation of the therapeutic potential of PDE9 inhibition.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Deninno MP,Andrews M,Bell AS,Chen Y,Eller-Zarbo C,Eshelby N,Etienne JB,Moore DE,Palmer MJ,Visser MS,Yu LJ,Zavadoski WJ,Michael Gibbs E

doi

10.1016/j.bmcl.2009.03.024

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

2537-41

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00342-4

journal_volume

19

pub_type

杂志文章

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