Abstract:
:The present work reports on the preparation of glass surfaces coated with NPPOC-protected aminooxy groups and their use for the patterning of oligonucleotides on glass slides and in capillary tubes. The method involves the use of surfaces coated with amino groups using (gamma-aminopropyl)triethoxy silane and subsequent grafting of the aminooxy groups by using the activated ester 1. The NPPOC-protected aminooxy groups on the surfaces can be cleaved upon irradiation. The free aminooxy groups so obtained are subsequently reacted with aldehyde-containing oligonucleotides to achieve efficient surface patterning.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Dendane N,Hoang A,Defrancq E,Vinet F,Dumy Pdoi
10.1016/j.bmcl.2008.03.054subject
Has Abstractpub_date
2008-04-15 00:00:00pages
2540-3issue
8eissn
0960-894Xissn
1464-3405pii
S0960-894X(08)00326-0journal_volume
18pub_type
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