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Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones.

Abstract：

:Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Das J,Rao CV,Sastry TV,Roshaiah M,Sankar PG,Khadeer A,Kumar MS,Mallik A,Selvakumar N,Iqbal J,Trehan S

doi

10.1016/j.bmcl.2004.10.073

subject

Has Abstract

pub_date

2005-01-17 00:00:00

pages

337-43

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(04)01312-5

journal_volume

15

pub_type

杂志文章

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