Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors.

Abstract:

:The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).

journal_name

Bioorg Med Chem Lett

authors

Cai T,Xian M,Wang PG

doi

10.1016/s0960-894x(02)00185-3

subject

Has Abstract

pub_date

2002-06-03 00:00:00

pages

1507-10

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960894X02001853

journal_volume

12

pub_type

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