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2'-Deoxy-2'(S)-ethinyl oligonucleotides: a modification which selectively stabilizes oligoadenylate pairing to DNA complements.

Abstract：

:Oligonucleotides consisting of 2'-deoxy-2'(S)-ethinyl-thymidine,-uridine, and -adenosine have been prepared. Whereas the modified pyrimidine oligonucleotides uniformly lead to weaker pairing affinity with DNA and RNA complements, the corresponding adenine oligonucleotides show enhanced thermal stability in duplexes with complementary DNA and decreased stability with RNA.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Buff R,Hunziker J

doi

10.1016/s0960-894x(98)00060-2

subject

Has Abstract

pub_date

1998-03-03 00:00:00

pages

521-4

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X98000602

journal_volume

8

pub_type

杂志文章

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