Could a common biochemical mechanism underlie addictions?

abstract：OBJECTIVE:The quality of 33 formulations of essential antimicrobial and antimalarial drugs (amoxicillin capsules, metronidazole tablets, sulfamethoxazole/trimethoprim tablets, quinine tablets and sulphadoxine/pyrimethamine tablets) marketed in Rwanda and Tanzania was assessed and the influence of tropical storage condi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kayumba PC,Risha PG,Shewiyo D,Msami A,Masuki G,Ameye D,Vergote G,Ntawukuliryayo JD,Remon JP,Vervaet C

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To assess the accuracy and precision of delivery from containers containing oral drops, both under optimal laboratory conditions and during use by volunteers using a variety of real pharmaceutical products and specially prepared fluids. METHODS:The effects of the physical properties (viscosit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brown D,Ford JL,Nunn AJ,Rowe PH

更新日期：2004-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Acquired long QT syndrome secondary to drug-induced QT prolongation and torsades de pointes has been reported for antiviral drugs. However, no studies have reported an association between corrected QT (QTc) prolongation and antiviral therapy in patients with novel coronavirus disease (COVID-...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhu S,Wang J,Wang Y,Chu J,Liu Y,Chen X,Chen X

更新日期：2020-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The most common complication of heparin therapy is bleeding. Allergic reactions to heparin are rare, and the mechanisms are poorly understood. We report on a case of acute systemic reaction after subcutaneous injections of a low-molecular-weight heparin (LMWH) in a patient with a genetic pre...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Leone S,Zuccoli ML,Fucile C,Storace S,Martelli A,Mattioli F

更新日期：2012-12-01 00:00:00

abstract：:To dose the anticonvulsant phenytoin (PHT) in a clinical situation is difficult because of the non-linear metabolism of the drug. Therefore many techniques have been advocated to aid dosage adjustments based on a single-point PHT concentration determined at steady-state (ss). We retrospectively investigated six method...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Ohtsubo K,Aoyama T

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. METHOD:Eleven healthy individuals (26-61 years of age) were evaluated at basel...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Agnew LL,Guffogg SP,Matthias A,Lehmann RP,Bone KM,Watson K

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kos-Kudła B,Ostrowska Z,Marek B,Ciesielska-Kopacz N,Sieminska L,Kajdaniuk D,Nowak M,Kudla M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HI...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Marfo K,Garala M,Kvetan V,Gasperino J

更新日期：2009-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Huang W,Li J,Qiu F,Wu X,Zhang J,Li X,Yao G,Zhu S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The calcium channel blocker diltiazem has been used widely as a cyclosporine (CsA)/tacrolimus-sparing agent. However, considerable interpatient variability in diltiazem's CsA/tacrolimus-sparing effect has been observed in many clinical studies. This study was carried out to investigate the i...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhou LY,Zuo XC,Chen K,Wang JL,Chen QJ,Zhou YN,Yuan H,Ma Y,Zhu LJ,Peng YX,Ming YZ

更新日期：2016-06-01 00:00:00

abstract：:Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metaboliz...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Schachter M

更新日期：1991-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cancer patients treated with cisplatin chemotherapy frequently experience drug-induced nephrotoxicity. Clinical studies using a single chemotherapeutic regimen or large sample sizes for patients with the SLC22A2 808T allele have not been reported. Here, we examined 95 patients with oesophage...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hinai Y,Motoyama S,Niioka T,Miura M

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： do Prado-Lima P,Knijnik L,Juruena M,Padilla A

更新日期：2001-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Midazolam (MDZ) is commonly used for sedating critically ill patients. The daily dose required for adequate sedation increases in increments over 100 h after administration. The objectives of this study were to characterize the MDZ pharmacokinetics in critically ill patients and to describe ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Aoyama T,Hirata K,Yamamoto Y,Yokota H,Hayashi H,Aoyama Y,Matsumoto Y

更新日期：2016-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:SB5 is a biosimilar to the reference adalimumab (ADL) currently in development. The primary study objective was to demonstrate pharmacokinetic (PK) equivalence of SB5 to European Union-sourced adalimumab (EU-ADL), and United States-sourced adalimumab (US-ADL) in healthy subjects. Safety, tol...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shin D,Lee Y,Kim H,Körnicke T,Fuhr R

更新日期：2017-12-01 00:00:00

abstract：:The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n = 50) or active ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Whitefield M,O'Kane CJ,Anderson S

更新日期：2002-12-01 00:00:00

abstract：:Drug-induced parotitis is a relatively uncommon adverse drug reaction. Most of the data on drug-induced parotitis consist of isolated case reports with few attempts at rechallenge to confirm the aetiology. Phenylbutazone and oxyphenbutazone have a significant number of reports suggesting that these drugs may be implic...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Thompson DF

更新日期：1993-08-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0.05 M ammonium acetate buffer containing 0.01 M octane sulphona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shiekh Salem M,Gharaibeh AM,Alkaysi HN,Badwan A

更新日期：1988-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Therapeutic effects of anti-VEGF agents, corticosteroids and laser therapy have been previously examined for treating macular oedema secondary to branch and central retinal vein occlusion (BRVO and CRVO). However, anti-VEGF efficacy has not been previously compared to corticosteroid or laser...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Qian T,Zhao M,Xu X

更新日期：2017-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION:We present a patient with schizophrenia who developed acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Omi T,Mitsui Y,Matsunaga H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Morgan O,Hawkins L,Edwards N,Dargan P

更新日期：2007-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Little is known about the ability of community pharmacists who are inexperienced in medication review to identify drug-related problems (DRPs). The objective of our study was to investigate the completeness of DRPs in terms of number, type and clinical relevance identified by community phar...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kwint HF,Faber A,Gussekloo J,Bouvy ML

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oster Svedberg K,McKenzie J,Larrivee-Elkins C

更新日期：2002-02-01 00:00:00

abstract：:Isolated human mononuclear cells exposed to either lipopolysaccharide or Staphylococcus aureus secreted interleukin-1 like material. The secretion was concentration dependent. The minimal detectable level in the test solution of lipopolysaccharide and Staphylococcus aureus was 200 pg/ml and 10(5) cells/ml respectively...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hansen EW,Christensen JD

更新日期：1990-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical use of fluconazole against fungal infections in renal transplant patients is complicated by the potentially marked and unpredictable drug-drug interactions (DDIs). We report a case of tacrolimus-fluconazole DDI in a stable renal transplant recipient and describe the mechanism, magni...

journal_title：Journal of clinical pharmacy and therapeutics

authors： He J,Yu Y,Yin C,Liu H,Zou H,Ma J,Yang W,Liu Y,Zhong L,Chen X

更新日期：2020-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cytochrome P450 1A2 (CYP1A2), CYP2B6 and inducible nitric oxide synthase (iNOS) are involved in the metabolism and action of many important therapeutic drugs, and genetic variants have been associated with interethnic differences in response to treatment, including chemotherapy. METHODS:Eig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Qi GZ,Zhang ZY,Wang X,Yin SJ,Lou YQ,Zhang GL

更新日期：2016-02-01 00:00:00

abstract：:The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickins...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wood MJ,Lund R,Beavan M

更新日期：1995-12-01 00:00:00

abstract：:Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patien...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sangrador G,Sánchez-Alcaraz A,Ubeda R,Ibañez P

更新日期：1990-08-01 00:00:00

abstract：:When assessing a health-care intervention the main question is--does it work? Often, a more difficult question needs to be answered--how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking,...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wiffen PJ,Moore RA

更新日期：1996-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The current pharmacotherapeutic treatment of major depressive disorder (MDD) generally takes weeks to be effective. As the molecular action of these drugs is immediate, the mechanistic basis for this lag is unclear. A drug that has a more rapid onset of action would be a major therapeutic ad...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Drewniany E,Han J,Hancock C,Jones RL,Lim J,Nemat Gorgani N,Sperry JK 3rd,Yu HJ,Raffa RB

更新日期：2015-04-01 00:00:00