Abstract:
:Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metabolized in the liver, with several pharmacologically inactive metabolites. As the elimination half-life is about 9 h the drug is usually given twice daily, but a once-daily modified release form is under investigation. Isradipine is effective monotherapy in essential hypertension, and has been successfully combined with pindolol and captopril. On the basis of more limited evidence it also appears to be beneficial in stable angina and in congestive cardiac failure. A trial is also under way to assess its antiatherogenic properties. Adverse effects are those predicted for a vasodilator calcium antagonist, and may be less frequent than for equivalent doses of nifedipine. This needs to be confirmed by more extensive clinical experience. Overall, isradipine can be considered favourably in essential hypertensives where a calcium channel blocker is indicated, particularly if it is desirable to avoid myocardial depression or to minimize reflex tachycardia. Its role in other cardiovascular disease awaits further evaluation.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Schachter Mdoi
10.1111/j.1365-2710.1991.tb00288.xsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
79-91issue
2eissn
0269-4727issn
1365-2710journal_volume
16pub_type
临床试验,杂志文章,评审abstract:WHAT IS KNOWN AND OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) are at higher risk of thrombotic complications. Studies have indicated that patients with T2DM have impaired clopidogrel-induced antiplatelet effect. Ticagrelor and prasugrel are two latest generation P2Y12 inhibitors with advantageous platelet i...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpt.12651
更新日期:2018-06-01 00:00:00
abstract::The retinoic acid syndrome (RAS) is an unpredictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most commonly in patients with acute promyelocytic leukaemia (APL). In this review, we describe the incidence, predictive factors, clinical course, outcome and treatme...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2710.2008.00935.x
更新日期:2008-08-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:There are no clinical reports that have compared topiroxostat, a selective xanthine oxidase inhibitor, with allopurinol in serum urate-lowering efficacy. The aim of this study was to compare the efficacy and safety of topiroxostat and allopurinol in Japanese hyperuricemic patients with or wi...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/jcpt.12391
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:There is a growing interest in investigating the role of glutamate receptors in the pathophysiology of schizophrenia. Indeed, the hyperdopaminergic theory of schizophrenia can explain only the positive symptoms of schizophrenia, whereas the glutamate hypothesis may provide a more comprehensive view of the ill...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2710.1999.00238.x
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2008.00910.x
更新日期:2008-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Carvedilol is the standard of care for heart failure (HF) patients. Carvedilol is partially metabolized by the highly polymorphic enzyme, CYP2D6. To reach an effective dose while avoiding adverse drug reactions (ADRs), testing of CYP2D6 genotype prior to carvedilol initiation may be consider...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12154
更新日期:2014-08-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Clinical pharmacokinetic profiles of clarithromycin and telithromycin in bronchopulmonary sites have not been fully characterized. This study aimed to describe in more detail the pharmacokinetics of the two macrolides in epithelial lining fluid (ELF) of human bronchi and to evaluate their ph...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12157
更新日期:2014-08-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2011.01266.x
更新日期:2011-08-01 00:00:00
abstract::The objectives of this study were: (a) to develop a drug serum level-based compliance measure which incorporated pharmacokinetic analysis of patient and drug parameters and to compare it to refill records, an indirect measure, and (b) to use that measure to determine whether pharmacist consultation increased complianc...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12164
更新日期:2014-08-01 00:00:00
abstract::Antimicrobials are frequently used to prevent infections. Principles of prophylaxis, and antimicrobial prophylaxis in surgery, tuberculosis, acquired immunodeficiency syndrome, influenza A, traveller's diarrhoea, malaria, recurrent otitis media, Haemophilus influenzae type b infection, pertussis, rheumatic fever, and ...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.1996.tb01147.x
更新日期:1996-08-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:With increased opioid use, drug-drug interactions (DDIs) and associated adverse events are growing among geriatric patients. However, the clinical significance of potential metabolic DDIs associated with opioid use has not been fully evaluated among geriatric patients. Particularly, cytochro...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.13113
更新日期:2020-10-01 00:00:00
abstract::A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis. We report on two patients, treated with felodipine and nifedipine for arterial hypertension, who presented with an exacerbation of their myasthenia gravis and a myasthenic syndrome or exacerbation of ...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1046/j.1365-2710.1998.00172.x
更新日期:1998-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.13201
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,meta分析
doi:10.1111/j.1365-2710.2009.01031.x
更新日期:2009-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Polypharmacy has a significant impact on patients' health with overall expenditure on over-the-counter (OTC) medicines representing a substantial burden in terms of cost of treatment. The aim of this study, which was conducted within the framework of a European Project funded by the European...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,多中心研究
doi:10.1111/jcpt.12601
更新日期:2018-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Neuraminidase inhibitors are important options for the treatment of infection by the influenza virus. For the treatment of severe influenza, parenteral administration of a neuraminidase inhibitor may be desirable. This study was conducted to evaluate the pharmacokinetic and safety profiles o...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpt.12056
更新日期:2013-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, ...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.12312
更新日期:2015-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Every prescriber knows that patients often do not take their medicines as prescribed. Hippocrates, the wise man of Kos, knew over two millennia ago. Our objective is to comment on the types of studies aimed at understanding and optimizing drug usage and to draw attention to the need to seek ...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 社论
doi:10.1111/jcpt.13325
更新日期:2021-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.12403
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1046/j.1365-2710.2003.00491.x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:There is evidence that patients are being prescribed potentially hazardous drug-drug combinations in general practice despite the use of computerized drug interaction alert systems. One reason for this may be that general practitioners (GPs) are overriding these alerts without properly checking them. AIMS:(...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1046/j.1365-2710.2002.00434.x
更新日期:2002-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase th...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12806
更新日期:2019-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:The CHOP regimen with rituximab (R-CHOP) remains the standard for chemotherapy in patients with aggressive non-Hodgkin's lymphoma (NHL). The cardiotoxicity of doxorubicin appears to be a key problem in clinical practice. We studied the cardiotoxicity of CHOP/R-CHOP regimen in a retrospective...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12124
更新日期:2014-04-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2010.01163.x
更新日期:2011-04-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable. CASE DESCRIPTION:A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including a...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.13018
更新日期:2019-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Current guidelines recommend a combination of clopidogrel and aspirin for management of patients who have experienced an acute coronary syndrome (ACS). Additional antiplatelet agents have been recently approved. Few comparative effectiveness studies are available for these new agents. Accord...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12209
更新日期:2014-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Low-dose methotrexate (LDMTX) has been widely used for many decades in clinical settings, with good safety profiles compared with those of high-dose methotrexate. LDMTX is also used as one of the off-label conservative therapies in treating placenta accreta (PA). Until now, only a few mild a...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.13050
更新日期:2020-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Clinical use of fluconazole against fungal infections in renal transplant patients is complicated by the potentially marked and unpredictable drug-drug interactions (DDIs). We report a case of tacrolimus-fluconazole DDI in a stable renal transplant recipient and describe the mechanism, magni...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1111/jcpt.13075
更新日期:2020-04-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:New first-in-class (FIC) drugs with novel mechanisms of action may be highly effective, but lack adequate safety information, and therefore may be associated with crucial post-marketing safety issues. The objective of this study was to evaluate the post-marketing risk of FIC drug with compar...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.13096
更新日期:2020-06-01 00:00:00