Guidelines for antimicrobial prophylaxis.

abstract：WHAT IS KNOWN AND OBJECTIVE:This study developed a population pharmacokinetic (PK) model of levetiracetam (LEV) for treating neonatal seizures (NS) and determined the influence of clinically relevant covariates to explain the interindividual variability and residual error. METHODS:Twenty newborns admitted to the Neona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lima-Rogel V,López-López EJ,Medellín-Garibay SE,Gómez-Ruiz LM,Romero-Méndez C,Milán-Segovia RC,Romano-Moreno S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring of clozapine as an aid in the treatment of schizophrenic states is commonly used in our hospital. OBJECTIVE:Development of a high-performance liquid chromatographic method for the determination of clozapine (CLZ) and its major metabolite desmethylclozapine (DMCLZ) in plasma and s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dumortier G,Lochu A,Zerrouk A,Van Nieuwenhuyse V,Colen de Melo P,Roche Rabreau D,Degrassat K

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2.50 and 5.00 mg/ ml) over a 30-day period. METHOD:Hig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oustric-Mendes AC,Huart B,Le Hoang MD,Perrin-Rosset M,Pailler FM,Darbord JC,Prognon P,Gard C,Pradeau D

更新日期：1997-08-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to elucidate the pharmacokinetics of erlotinib in Japanese patients with advanced non-small cell lung cancer (NSCLC) and to investigate the relationship between erlotinib exposure and the occurrence of interstitial lung disease (ILD)-like events. METHODS:Population pharmaco...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Emoto-Yamamoto Y,Iida S,Kawanishi T,Fukuoka M

更新日期：2015-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Niacin commonly causes cutaneous flushing, which is partially alleviated by laropiprant, a selective antagonist of prostaglandin D2 at the DP1 receptor. Here we report an unusually high incidence of exanthematous eruption associated with the use of the extended-release (ER) niacin/laropipran...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yang YL,Hu M,Chang M,Tomlinson B

更新日期：2013-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mohee K,Wheatcroft SB

更新日期：2014-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

更新日期：2019-04-01 00:00:00

abstract：:The paper describes an in-depth study of the parenteral fat emulsions, Intralipid 20% and Ivelip 20%. A large number of emulsion samples from separate containers and batches was sampled. The parameters measured were droplet size (both by photon correlation and laser diffraction), pH and zeta potential. These parameter...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Washington C,Koosha F,Davis SS

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To probe the pharmacokinetic basis for the use of levofloxacin for complicated skin and skin-structure infections (SSSIs) at a once-daily dosage of 750 mg by investigating its penetration into skin tissue. METHOD:Ten healthy volunteers were administered three oral, once-daily 750 mg doses of levofloxacin, an...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chow AT,Chen A,Lattime H,Morgan N,Wong F,Fowler C,Williams RR

更新日期：2002-04-01 00:00:00

abstract：:A stability-indicating reversed phase high-performance liquid chromatographic assay for prazosin was developed to investigate the feasibility of a transdermal dosage form. The assay enabled detection of drug concentrations down to 0.05 microgram/ml and the quantification of the drug in both permeation fluids and in ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tenjarla SN,Tseggai A

更新日期：1992-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anton C,Cox AR,Watson RD,Ferner RE

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To report three cases of alopecia induced by the anticoagulant enoxaparin in cerebral venous thrombosis (CVT) patients. CASE SUMMARY:Three female patients were treated initially with direct intrasinus urokinase, and then followed by low-molecular-weight heparin (LMWH) enoxaparin at 1 mg/kg given subcutaneous...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang YY,Po HL

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：:A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis. We report on two patients, treated with felodipine and nifedipine for arterial hypertension, who presented with an exacerbation of their myasthenia gravis and a myasthenic syndrome or exacerbation of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pina Latorre MA,Cobeta JC,Rodilla F,Navarro N,Zabala S

更新日期：1998-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Beginning in the 1950s, a family of potent opioids was synthesized and developed (fentanyl and analogues). They continue to serve as valuable analgesic agents. But the recent spike and notoriety of their abuse has raised alarm, even calls for tighter control. We review the trajectory of thes...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Raffa RB,Pergolizzi JV Jr,LeQuang JA,Taylor R Jr,NEMA Research Group.,Colucci S,Annabi MH

更新日期：2018-02-01 00:00:00

abstract：:The primary aim of this study was to assess patterns of prescribing of analgesic medications in a primary care setting in South Africa. Medication records of 47,103 patients for the year 1995 were retrospectively reviewed. Analgesic agents represented 12.3% of the total number and 14.2% of the total cost of all the pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Truter I

更新日期：1997-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Serum sialic acid is a recently investigated potential risk-marker for cardiovascular complications. There is a known association between sialic acid and cardiovascular complications in diabetes mellitus. We aimed to investigate the effect of antidiabetic drugs on the serum concentration of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rahman IU,Malik SA,Bashir M,Khan RU,Idrees M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Vancomycin is often used in antibiotic infusions for hospitalized patients and it is advantageous to prepare such intravenous solutions in advance. The objective of this study was to investigate the long-term stability of this antibiotic stored at 4 degrees C in polyvinyl chloride (PVC) bags. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galanti LM,Hecq JD,Vanbeckbergen D,Jamart J

更新日期：1997-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION:We present a patient with schizophrenia who developed acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Omi T,Mitsui Y,Matsunaga H

更新日期：2018-02-01 00:00:00

abstract：:A drug use review of omeprazole was carried out at two centres in the Yorkshire Region from December 1990 to April 1991. Data collection documents were used and 66 patients in total were audited. Thirteen patients (19.7%) were treated for indications outside the product licence and 18 patients (27.3%) were treated for...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Norris CM,McManus PV,Petty D,Kay EA

更新日期：1992-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:With the ageing of the population also comes increasing comorbidities and the use of multiple medications and administration methods, along with greater susceptibility to adverse drug reactions. Dosage form modification to facilitate drug administration in older adults can be potentially pro...

journal_title：Journal of clinical pharmacy and therapeutics

authors： McDerby N,Kosari S,Bail K,Shield A,Peterson G,Naunton M

更新日期：2019-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Carvedilol is the standard of care for heart failure (HF) patients. Carvedilol is partially metabolized by the highly polymorphic enzyme, CYP2D6. To reach an effective dose while avoiding adverse drug reactions (ADRs), testing of CYP2D6 genotype prior to carvedilol initiation may be consider...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shihmanter R,Nulman I,Goland S,Caspi A,Bar-Haim A,Harary I,Berkovitch M,Arcavi L

更新日期：2014-08-01 00:00:00

abstract：:The literature indicates that the relative nephrotoxicities of the three drugs used in this investigation are gentamicin > tobramycin > or = netilmicin. Serum creatinine levels over time were used in an attempt to elucidate the situation. They varied widely in all three groups and in controls in theatre. No definite t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bertram D,Summers R

更新日期：1993-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) are at higher risk of thrombotic complications. Studies have indicated that patients with T2DM have impaired clopidogrel-induced antiplatelet effect. Ticagrelor and prasugrel are two latest generation P2Y12 inhibitors with advantageous platelet i...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shang LL,Guo DD,Zhao HY,Quan AJ,Cao PG

更新日期：2018-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Rutoside (rutin; quercetin rutinoside) is a glycoside found in various plant products, including apples, citrus fruits and cranberries. Hydroxyethylrutosides (HR) are semisynthetic derivatives sold as standardized products for the treatment of chronic venous insufficiency (CVI). Commercially...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Aziz Z,Tang WL,Chong NJ,Tho LY

更新日期：2015-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Psoriatic arthritis is an autoimmune disease characterized by chronic inflammation of the skin and joints. Anti-TNF drugs reduce the severity of the disease in the long term. This study compares the efficacy and safety of adalimumab, etanercept, infliximab and golimumab in patients with psor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fénix-Caballero S,Alegre-del Rey EJ,Castaño-Lara R,Puigventós-Latorre F,Borrero-Rubio JM,López-Vallejo JF

更新日期：2013-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen Y,Chang J,Yin R,Wen J,Ma B,Zuo W,Zhang X,Wei J

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Studies on antiepileptic drug utilization are important for the optimization of drug therapy and drug control. The present study was to evaluate the drug utilization pattern of standard antiepileptic drugs and traditional Chinese medicines (TCMs) in the treatment of different types of epilepsy in a general ho...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen LC,Chen YF,Yang LL,Chou MH,Lin MF

更新日期：2000-04-01 00:00:00