Patterns of analgesic prescribing in a South African primary care setting.

abstract：WHAT IS KNOWN AND OBJECTIVE:Edoxaban has three dose adjustment factors (creatinine clearance, 15-50 mL/min; body weight, 60 kg or less; and concomitant medication with potent P-glycoprotein inhibitors) to prevent bleeding that results from elevated blood concentrations of the drug. A dose reduction (from 60 to 30 mg/da...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Takase T,Ikesue H,Nakagawa H,Kinoshita M,Muroi N,Kitai T,Furukawa Y,Hashida T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HI...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Marfo K,Garala M,Kvetan V,Gasperino J

更新日期：2009-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Ticagrelor is a reversibly binding and selective P2Y12 -receptor antagonist approved for the prevention of atherothrombotic events in patients with acute coronary syndromes. As bleeding events remain a hazard with antiplatelet therapy, this study investigated the effect of the vasopressin ag...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Teng R,Mitchell PD,Butler K

更新日期：2014-04-01 00:00:00

abstract：:New treatments for relapse of acute myeloid leukaemia (AML), include gemtuzumab ozogamicin (GO), an anti-CD33 monoclonal antibody. We describe a second case of GO-induced sinusoidal obstructive syndrome (SOS) effectively treated with defibrotide (DF). No stem-cell transplantation was involved. On day 23 after the firs...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lannoy D,Decaudin B,Grozieux de Laguérenne A,Barrier F,Pignon JM,Wetterwald M,Odou P

更新日期：2006-08-01 00:00:00

abstract：:Graft patency is a major factor contributing to the long-term results of coronary artery bypass graft (CABG) surgery. The systematic overview of the Antiplatelet Trialists' Collaboration provides unequivocal evidence that antiplatelet therapy reduces by nearly one-half the odds of coronary graft occlusion following CA...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galea J,Manché A,Goiti JJ,Locke TJ,Wilkinson GA,Smith GH

更新日期：1994-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) that has activity in several types of malignancies. One of the uncommon adverse effects is spontaneous bowel perforation. In patients who have undergone cystectomy, a loop of small bowel is often used...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Liu SV,Gollard R,Iqbal S

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：:Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jones AF,Vale JA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acute coronary syndrome (ACS) is a leading cause of death. Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines. STUDY METHOD...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rajapakse S,Rodrigo PC,Selvachandran J

更新日期：2010-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Drug-drug interaction is a potential cause of adverse drug reactions. The incidence of such drug interactions in university hospitals in Thailand is unknown. PURPOSE:To estimate the rate of potential drug-drug interactions in outpatients of a typical Thai university hospital, and to identify risk factors fo...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Janchawee B,Wongpoowarak W,Owatranporn T,Chongsuvivatwong V

更新日期：2005-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRIs) are the first line of medication for OCD treatment; however, 40%-60% of patients with OCD do not respond to SSRIs adequately. There are growing pieces of evidence which...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abdolhosseinzadeh S,Sina M,Ahmadiani A,Asadi S,Shams J

更新日期：2019-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adverse drug events (ADE), common and underestimated in ICU patients, have direct consequences on length of stay, mortality and hospital costs. Critically ill patients with HIV/AIDS are at a high risk of ADE because of their need for multiple drug therapies. ADE can be prevented, especially ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ramos GV,Guaraldo L,Japiassú AM,Bozza FA

更新日期：2015-02-01 00:00:00

abstract：:The extent and factors that influence drug use were studied in two rural cohorts of Finnish men. The men aged between 65 and 84 years belonged to the Finnish study population of the 25-year follow-up of the 'Seven Countries Study'. Of the original 1,711 men in 1959, 766 were still alive in 1984. The participation rate...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Enlund H,Martikainen J,Turakka H,Nissinen A

更新日期：1990-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The CHOP regimen with rituximab (R-CHOP) remains the standard for chemotherapy in patients with aggressive non-Hodgkin's lymphoma (NHL). The cardiotoxicity of doxorubicin appears to be a key problem in clinical practice. We studied the cardiotoxicity of CHOP/R-CHOP regimen in a retrospective...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Limat S,Daguindau E,Cahn JY,Nerich V,Brion A,Perrin S,Woronoff-Lemsi MC,Deconinck E

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Glucocorticoid-induced diabetes mellitus (GIDM) increases the risk of diabetes mellitus (DM)-related complications but is generally difficult to detect in clinical settings. The criteria for diagnosing GIDM have not been established. Recently, medical information databases (MIDs) have been u...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Imatoh T,Sai K,Hori K,Segawa K,Kawakami J,Kimura M,Saito Y

更新日期：2017-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cancer patients treated with cisplatin chemotherapy frequently experience drug-induced nephrotoxicity. Clinical studies using a single chemotherapeutic regimen or large sample sizes for patients with the SLC22A2 808T allele have not been reported. Here, we examined 95 patients with oesophage...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hinai Y,Motoyama S,Niioka T,Miura M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Patients with congestive heart failure (CHF) are at risk for hyperkalemia because of coexisting comorbidities and use of multiple medications that impair potassium (K) excretion such as angiotensin converting enzyme (ACE) inhibitors. OBJECTIVE:To identify clinical factors associated with hyperkalemia on ini...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ramadan FH,Masoodi N,El-Solh AA

更新日期：2005-06-01 00:00:00

abstract：:A study was conducted in two groups of healthy volunteers to assess whether the time of administration (10 min before the meal versus 60 min after the meal) influences the pharmacokinetics and absorption kinetics of a slow-release theophylline product (Teonova). In the first group (Group A, n = 10), the drug was given...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Boner AL,Sette L,Messori A,Plebani M,Vallone G,Martini N

更新日期：1988-02-01 00:00:00

abstract：:A single dose pharmacokinetic study was conducted on two sustained-release formulations (75 mg) of indomethacin (Indocid capsules 'A' and Indogesic tablets 'B'). The study was carried out on 22 healthy male volunteers, who received a single oral dose (75 mg) of each product according to a randomized crossover design. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hasan MM,Najib NM,Muti HY

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Crane IM,Mulhern MG,Nema S

更新日期：2003-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:SB5 is a biosimilar to the reference adalimumab (ADL) currently in development. The primary study objective was to demonstrate pharmacokinetic (PK) equivalence of SB5 to European Union-sourced adalimumab (EU-ADL), and United States-sourced adalimumab (US-ADL) in healthy subjects. Safety, tol...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shin D,Lee Y,Kim H,Körnicke T,Fuhr R

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy. METHOD:Serum samples examined in the study were obtained from 41 paediatric patients (23 male, 18 female) with epilepsy on phenytoin monotherapy. Their age ranged from 1 to...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kodama H,Kodama Y,Itokazu N,Shinozawa S,Kanemaru R,Sugimoto T

更新日期：2001-06-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The role of long-term glycaemic control in minimizing long-term complications of diabetes mellitus is evidence-based and national guidelines recommend a target glycosylated haemoglobin level of approximately 7%. Although the role of self-monitoring blood and urine glucose is less well defined, this activity ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Stewart D,McCaig D,Davie A,Juroszek L,Blackwood L,Findlay N,McCarthy S

更新日期：2004-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Drug prescribing is an essential part of inpatient care, and prescription errors/omissions have the potential to lead to disastrous consequences. Paediatric inpatient prescribing is particularly sensitive to error due to the weight-adjusted dosing of many medications prescribed in the acute ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bolt R,Yates JM,Mahon J,Bakri I

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： do Prado-Lima P,Knijnik L,Juruena M,Padilla A

更新日期：2001-08-01 00:00:00

abstract：:To dose the anticonvulsant phenytoin (PHT) in a clinical situation is difficult because of the non-linear metabolism of the drug. Therefore many techniques have been advocated to aid dosage adjustments based on a single-point PHT concentration determined at steady-state (ss). We retrospectively investigated six method...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Ohtsubo K,Aoyama T

更新日期：1988-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's synd...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tolomeo M,Colomba C,Meli M,Cascio A

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To describe sore throat management by primary care physicians in Poland. METHODS:We sent questionnaires to all primary care doctors in Podlaskie voievodship (north-eastern Poland) with clinical vignettes depicting patients with symptoms of sore throat. The probability of bacterial (streptococcal) infection w...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chlabicz S,Pytel-Krolczuk B,Ołtarzewska AM,Marcinowicz L

更新日期：2008-04-01 00:00:00