Case report of perforation of an ileal neobladder after treatment of rectal cancer with bevacizumab and comment on mechanisms of intestinal perforation associated with bevacizumab.

abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

更新日期：2000-10-01 00:00:00

abstract：:The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study wi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Molinaro M,Regazzi MB,Raffaghello S,Buggia I,Iacona I,Graziani P,Specchia G,Melzi D'eril G

更新日期：1994-04-01 00:00:00

abstract：INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anton C,Cox AR,Watson RD,Ferner RE

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment of infants and children, as well as elderly people, who are more sensitive to dosage errors. Previous studies revealed significant dosage inaccuracies with measuring...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dockhorn S,Feuersenger D,Schuenemann S,Knauf B,Duerr S,Schubert-Zsilavecz M,Abdel-Tawab M

更新日期：2010-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to compare the ability of statin monotherapy (ST group), omega-3 fatty acid monotherapy (OM_A group) and combination therapy with omega-3 fatty acids and a statin (OM_S group), to reduce triglyceride (TG) levels in patients with hypertriglyceridaemia. METHODS:In this retros...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Jeong YJ,Yang SJ,Baik SJ,Lee H,Lee SH,Cho JH,Choi IY,Yim HW,Yoon KH

更新日期：2016-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Different population pharmacokinetics (PPK) models of tacrolimus have been established in various populations. However, the tacrolimus PPK model in paediatric systemic lupus erythematosus (PSLE) is still undefined. This study aimed to establish the tacrolimus PPK model in Chinese PSLE. MET...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang DD,Lu JM,Li Q,Li ZP

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Patients with congestive heart failure (CHF) are at risk for hyperkalemia because of coexisting comorbidities and use of multiple medications that impair potassium (K) excretion such as angiotensin converting enzyme (ACE) inhibitors. OBJECTIVE:To identify clinical factors associated with hyperkalemia on ini...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ramadan FH,Masoodi N,El-Solh AA

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring of clozapine as an aid in the treatment of schizophrenic states is commonly used in our hospital. OBJECTIVE:Development of a high-performance liquid chromatographic method for the determination of clozapine (CLZ) and its major metabolite desmethylclozapine (DMCLZ) in plasma and s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dumortier G,Lochu A,Zerrouk A,Van Nieuwenhuyse V,Colen de Melo P,Roche Rabreau D,Degrassat K

更新日期：1998-02-01 00:00:00

abstract：:Drug infusions can be exposed for prolonged periods to 'in-use' conditions where the temperature of an infusion in a holster-worn infusion pump may reach 37 degrees C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5-fluorouracil and mitozantrone) and one analgesic infusion (diamorphine H...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Northcott M,Allsopp MA,Powell H,Sewell GJ

更新日期：1991-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Linezolid, a member of the oxazolidinone class of antibacterial drugs, is approved by the US Food and Drug Administration (FDA) for the treatment of vancomycin-resistant Enterococcus faecium infections, nosocomial and community-acquired pneumonia, as a part of anti tubercular regimen and com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Singhania SVK,Shenoy S,Kapoor D

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scheele J,Diergarten K,Drevs J,Niazi FR

更新日期：2013-02-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:One-third of patients with epilepsy are resistant to anti-epileptic drugs (AEDs). Drug-resistant epilepsy is believed to be multifactorial involving both genetic and non-genetic factors. Genetic variations in the ABCB1 gene encoding the drug efflux transporter, p-glycoprotein (p-gp), may inf...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Keangpraphun T,Towanabut S,Chinvarun Y,Kijsanayotin P

更新日期：2015-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. CASE SUMMARY DESCRIPTION:The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglycerid...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ma S,Liu S,Wang Q,Chen L,Yang P,Sun H

更新日期：2020-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang T,Cheng H,Li Y,Dong YZ,Zhang Y,Cheng XL,Wang AM,Dong YL

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Both metformin and acarbose are recommended monotherapy and add-on therapy in type 2 diabetes mellitus (T2DM). A fixed-dose combination (FDC) of acarbose and metformin has been developed to reduce pill burden and potentially improve compliance. The current study investigated the bioequivalen...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim S,Jang IJ,Shin D,Shin DS,Yoon S,Lim KS,Yu KS,Li J,Zhang H,Liu Y,Brendel E,Blode H,Wang Y

更新日期：2014-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cytochrome P450 1A2 (CYP1A2), CYP2B6 and inducible nitric oxide synthase (iNOS) are involved in the metabolism and action of many important therapeutic drugs, and genetic variants have been associated with interethnic differences in response to treatment, including chemotherapy. METHODS:Eig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Qi GZ,Zhang ZY,Wang X,Yin SJ,Lou YQ,Zhang GL

更新日期：2016-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Little is known about the ability of community pharmacists who are inexperienced in medication review to identify drug-related problems (DRPs). The objective of our study was to investigate the completeness of DRPs in terms of number, type and clinical relevance identified by community phar...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kwint HF,Faber A,Gussekloo J,Bouvy ML

更新日期：2014-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:With increased opioid use, drug-drug interactions (DDIs) and associated adverse events are growing among geriatric patients. However, the clinical significance of potential metabolic DDIs associated with opioid use has not been fully evaluated among geriatric patients. Particularly, cytochro...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim JH,Kim JY,Lee N,Yee J,Gwak HS

更新日期：2020-10-01 00:00:00

abstract：:Midazolam concentration curves versus time were analysed in 10 otherwise healthy patients (ASA I-II) with inferior limb pathologies. The benzodiazepine was used as an adjuvant agent to epidural anaesthesia in view of its lower residual effect compared with other intravenous benzodiazepines. Midazolam pharmacokinetics...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sánchez-Alcaraz A,Sangrador G,Laguarda M,Quintana B

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To assess the accuracy and precision of delivery from containers containing oral drops, both under optimal laboratory conditions and during use by volunteers using a variety of real pharmaceutical products and specially prepared fluids. METHODS:The effects of the physical properties (viscosit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brown D,Ford JL,Nunn AJ,Rowe PH

更新日期：2004-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical pharmacists actively participate in patient care via patients' medication use. Yet the setting of Coronavirus Disease 2019 (COVID-19) limits patient contact with healthcare personnel. We aimed to review the services provided and drug-related problems detected using telemonitoring me...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Surapat B,Sungkanuparph S,Kirdlarp S,Lekpittaya N,Chunnguleum K

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lee DG,Chae H,Yim DS,Park SH,Choi SM,Kim S,Choi JH,Yoo JH,Shin WS

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Morgan O,Hawkins L,Edwards N,Dargan P

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:A pain relief score 50% of the maximum is often used as a clinically meaningful outcome in meta-analyses of analgesic trials. This arbitrary value requires validation. OBJECTIVE:To determine the optimum pain relief score for predicting pain relief sufficient to obviate the need for analgesic remedication in...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Li Wan Po A,Petersen B

更新日期：2006-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abodunde OA,LevakaVeera RR,Desai R,Nweke N,Berrou M

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of intervention in drug interactions of antiretroviral drugs with coadministered agents by a clinical pharmacist in outpatient HIV-treatment. METHODS:The study design included two intervention arms (A and B), which were both preceded by a control observation period. In arm A, a com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Maat MM,de Boer A,Koks CH,Mulder JW,Meenhorst PL,van Gorp EC,Mairuhu AT,Huitema AD,Beijnen JH

更新日期：2004-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Two NS3/4A protease inhibitors (PIs), telaprevir and boceprevir, were recently approved in the United States. The primary objective was to compare the efficacy and safety of triple therapies including either PI to dual therapy in patients with chronic hepatitis C genotype 1; the secondary ob...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Park C,Jiang S,Lawson KA

更新日期：2014-02-01 00:00:00