当前位置： SCI文献检索 > JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS期刊下所有文献 > Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study.

Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study.

Abstract：

BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsychotics olanzapine or risperidone as well as opposite-sex sib pairs. METHODS:Twin and sib pairs were identified by a telephone screening. Measured data on weight and other clinical variables were obtained cross-sectionally and retrospectively from medical records. In seven monozygotic twin pairs and 12 sib pairs (total number of patients treated: n = 38, mean age 29.5 +/- 9.5, range 13.7-54.3 years), the similarity in BMI (kg/m(2)) change under these atypical antipsychotics (atypical Delta BMI) and upon additional inclusion of BMI change under prior antipsychotic medication (total Delta BMI) was explored. RESULTS:For total Delta BMI we found greater similarity in antipsychotic-induced BMI change in MZ twin pairs than in sib pairs (intrapair difference) with a heritability of h(2) = 0.6, but not for atypical Delta BMI, possibly because of a genetically influenced weight plateau achieved under antipsychotic medication. CONCLUSION:The results of the present and our previous report suggest a contribution of genetic factors in antipsychotic-induced weight gain of 60-80%.

journal_name

J Clin Pharm Ther

journal_title

Journal of clinical pharmacy and therapeutics

authors

Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

doi

10.1111/j.1365-2710.2009.01084.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

207-11

issue

2

eissn

0269-4727

issn

1365-2710

pii

JCP1084

journal_volume

35

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS文献大全
  • The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy.

    abstract：WHAT IS KNOWN AND OBJECTIVE:6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (ciclopirox) and specifically its olamine salt 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone 2-aminoethanol salt (ciclopirox olamine) are anti-fungal agents currently used for the treatment of mild to moderate cutaneous fungal infection. Our ob...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.2010.01172.x

    authors： Weir SJ,Patton L,Castle K,Rajewski L,Kasper J,Schimmer AD

    更新日期：2011-04-01 00:00:00

  • Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-ana...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/jcpt.12382

    authors： Suksomboon N,Poolsup N,Punthanitisarn S

    更新日期：2016-04-01 00:00:00

  • Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study.

    abstract：:The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n = 50) or active ...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2710.2002.00439.x

    authors： Whitefield M,O'Kane CJ,Anderson S

    更新日期：2002-12-01 00:00:00

  • Population pharmacokinetics of tacrolimus in paediatric systemic lupus erythematosus based on real-world study.

    abstract：WHAT IS KNOWN AND OBJECTIVES:Different population pharmacokinetics (PPK) models of tacrolimus have been established in various populations. However, the tacrolimus PPK model in paediatric systemic lupus erythematosus (PSLE) is still undefined. This study aimed to establish the tacrolimus PPK model in Chinese PSLE. MET...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12707

    authors： Wang DD,Lu JM,Li Q,Li ZP

    更新日期：2018-08-01 00:00:00

  • How high should total pain-relief score be to obviate the need for analgesic remedication in acute pain? Estimation using signal detection theory and individual-patient meta-analysis.

    abstract：BACKGROUND:A pain relief score 50% of the maximum is often used as a clinically meaningful outcome in meta-analyses of analgesic trials. This arbitrary value requires validation. OBJECTIVE:To determine the optimum pain relief score for predicting pain relief sufficient to obviate the need for analgesic remedication in...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1365-2710.2006.00719.x

    authors： Li Wan Po A,Petersen B

    更新日期：2006-04-01 00:00:00

  • Is it tinidazole-induced pancreatitis?

    abstract：WHAT IS KNOWN AND OBJECTIVE:Metronidazole is one of the drugs with a well-recognized potential to rarely cause acute pancreatitis. The relation of other drugs of the 5-aminoimidazole group (e.g. tinidazole) to acute pancreatitis remains unknown. For the treatment of protozoal infections, tinidazole may be considered as...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type：

    doi：10.1111/jcpt.12307

    authors： Hegazi MO,Saleh F,John JE

    更新日期：2015-10-01 00:00:00

  • Whole saliva and plasma levels of clozapine and desmethylclozapine.

    abstract：BACKGROUND:Therapeutic drug monitoring of clozapine as an aid in the treatment of schizophrenic states is commonly used in our hospital. OBJECTIVE:Development of a high-performance liquid chromatographic method for the determination of clozapine (CLZ) and its major metabolite desmethylclozapine (DMCLZ) in plasma and s...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2710.1998.00132.x

    authors： Dumortier G,Lochu A,Zerrouk A,Van Nieuwenhuyse V,Colen de Melo P,Roche Rabreau D,Degrassat K

    更新日期：1998-02-01 00:00:00

  • Drug-use pattern of Chinese herbal medicines in insomnia: a 4-year survey in Taiwan.

    abstract：BACKGROUND AND OBJECTIVE:Insomnia is a common complaint in the general population. Interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in Taiwan. We undertook a survey to define the drug utilization patterns of Chinese herbal medicines (CM) for insomnia in Taiwan....

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.2009.01038.x

    authors： Chen LC,Chen IC,Wang BR,Shao CH

    更新日期：2009-10-01 00:00:00

  • Hormone replacement therapy in postmenopausal asthmatic women.

    abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2710.2000.00310.x

    authors： Kos-Kudła B,Ostrowska Z,Marek B,Ciesielska-Kopacz N,Sieminska L,Kajdaniuk D,Nowak M,Kudla M

    更新日期：2000-12-01 00:00:00

  • Trends in pharmacists' medication order review in French hospitals from 2006 to 2009: analysis of pharmacists' interventions from the Act-IP© website observatory.

    abstract：WHAT IS KNOWN AND OBJECTIVES:The French Society of Clinical Pharmacy has developed a website, named Act-IP©, enabling hospital pharmacists to document and analyse pharmacists' interventions (PIs) proposed during medication order review when a drug-related problem is detected. This study analyses PIs documented in Act-I...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12214

    authors： Bedouch P,Sylvoz N,Charpiat B,Juste M,Roubille R,Rose FX,Bosson JL,Conort O,Allenet B,French Society of Clinical Pharmacy's Act-IP© Group.

    更新日期：2015-02-01 00:00:00

  • A retrospective study to determine the impact of medical- and lifestyle-based contraindications to a prescribed HAART regimen on clinical outcomes and adherence.

    abstract：OBJECTIVE:To determine whether patients who are prescribed a highly active antiretroviral therapy regimen, that minimizes medical and lifestyle contraindications, will be better able to adhere to their drug regimens and will have better clinical outcomes, than patients who do not have such a regimen. METHODS:A retrosp...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.2006.00755.x

    authors： Lal LS,Grimes RM,Swint JM,Risser J

    更新日期：2006-10-01 00:00:00

  • Exploration of optimal dosing regimens of vancomycin in patients infected with methicillin-resistant Staphylococcus aureus by modeling and simulation.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12123

    authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

    更新日期：2014-04-01 00:00:00

  • Clinically significant pharmacokinetic drug interactions between antiepileptic drugs.

    abstract：:Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonly used antiepileptics...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2710.1999.00201.x

    authors： Tanaka E

    更新日期：1999-04-01 00:00:00

  • Population analysis for the optimization of digoxin treatment in Japanese paediatric patients.

    abstract：BACKGROUND AND OBJECTIVES:Information about the pharmacokinetics of digoxin in paediatric patients is limited. We therefore aimed to investigate the effects of physiological factors on the digoxin clearance in Japanese paediatric patients. METHOD:We used routinely collected therapeutic drug monitoring data (n=544), de...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2710.1999.00221.x

    authors： Suematsu F,Minemoto M,Yukawa E,Higuchi S

    更新日期：1999-06-01 00:00:00

  • Lemierre's syndrome: One rare disease-Two case studies.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. CASE DESCRIPTION:We present two cases of Lemierr...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type：

    doi：10.1111/jcpt.12774

    authors： Le C,Gennaro D,Marshall D,Alaev O,Bryan A,Gelfman A,Wang Z

    更新日期：2019-02-01 00:00:00

  • Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Cytochrome P450 1A2 (CYP1A2), CYP2B6 and inducible nitric oxide synthase (iNOS) are involved in the metabolism and action of many important therapeutic drugs, and genetic variants have been associated with interethnic differences in response to treatment, including chemotherapy. METHODS:Eig...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12351

    authors： Qi GZ,Zhang ZY,Wang X,Yin SJ,Lou YQ,Zhang GL

    更新日期：2016-02-01 00:00:00

  • Steroids in multiple sclerosis.

    abstract：:Steroids are widely used in treating the relapse of multiple sclerosis. There is no place for long term steroid therapy of this disease. Current practice is a short course of high dose methylprednisolone which can be repeated after an interval, has proven safety and objectively accelerates recovery. ...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi：10.1111/j.1365-2710.1994.tb00677.x

    authors： Griffiths TD,Newman PK

    更新日期：1994-08-01 00:00:00

  • Evaluation of pregabalin-induced adverse events related to falls using the FDA adverse event reporting system and Japanese Adverse Drug Event Report databases.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12790

    authors： Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

    更新日期：2019-04-01 00:00:00

  • Post-marketing safety-related regulatory actions on first-in-class drugs: A double-cohort study.

    abstract：WHAT IS KNOWN AND OBJECTIVE:New first-in-class (FIC) drugs with novel mechanisms of action may be highly effective, but lack adequate safety information, and therefore may be associated with crucial post-marketing safety issues. The objective of this study was to evaluate the post-marketing risk of FIC drug with compar...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.13096

    authors： Ikeda J,Kaneko M,Narukawa M

    更新日期：2020-06-01 00:00:00

  • Development of a novel algorithm for detecting glucocorticoid-induced diabetes mellitus using a medical information database.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Glucocorticoid-induced diabetes mellitus (GIDM) increases the risk of diabetes mellitus (DM)-related complications but is generally difficult to detect in clinical settings. The criteria for diagnosing GIDM have not been established. Recently, medical information databases (MIDs) have been u...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12499

    authors： Imatoh T,Sai K,Hori K,Segawa K,Kawakami J,Kimura M,Saito Y

    更新日期：2017-04-01 00:00:00

  • Diagnosis and treatment of low T3 syndrome in neurocritical patients.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.13162

    authors： Chen Y,Chang J,Yin R,Wen J,Ma B,Zuo W,Zhang X,Wei J

    更新日期：2020-08-01 00:00:00

  • Long-term stability of vancomycin hydrochloride in intravenous infusions.

    abstract：BACKGROUND AND OBJECTIVE:Vancomycin is often used in antibiotic infusions for hospitalized patients and it is advantageous to prepare such intravenous solutions in advance. The objective of this study was to investigate the long-term stability of this antibiotic stored at 4 degrees C in polyvinyl chloride (PVC) bags. ...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.1997.tb00018.x

    authors： Galanti LM,Hecq JD,Vanbeckbergen D,Jamart J

    更新日期：1997-10-01 00:00:00

  • Qualitative studies on alpha-interferon-2b in prolonged continuous infusion regimes using gradient elution high-performance liquid chromatography.

    abstract：:The treatment of home-based cancer patients with continuous infusion chemotherapy requires that complete courses of medication in pre-filled syringes are provided on an out-patient basis. The infusion must remain stable prior to use during refrigerated storage (up to 14 days) and during infusion from holster-worn ambu...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.1988.tb00185.x

    authors： Palmer AJ,Sewell GJ,Rowland CG

    更新日期：1988-06-01 00:00:00

  • Clinically significant drug-drug interaction between tacrolimus and fluconazole in stable renal transplant recipient and literature review.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical use of fluconazole against fungal infections in renal transplant patients is complicated by the potentially marked and unpredictable drug-drug interactions (DDIs). We report a case of tacrolimus-fluconazole DDI in a stable renal transplant recipient and describe the mechanism, magni...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/jcpt.13075

    authors： He J,Yu Y,Yin C,Liu H,Zou H,Ma J,Yang W,Liu Y,Zhong L,Chen X

    更新日期：2020-04-01 00:00:00

  • Ceftriaxone-associated renal toxicity in adults: a case report and recommendations for the management of such cases.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type：

    doi：10.1111/jcpt.12358

    authors： Shen-Hua W,Fan-Yi M,Qing-Ling Z,Li-Na Z,Li-Jun M

    更新日期：2016-06-01 00:00:00

  • Linezolid-induced rare triad of hypoglycaemia, bone marrow suppression and hyponatraemia in elderly.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Linezolid, a member of the oxazolidinone class of antibacterial drugs, is approved by the US Food and Drug Administration (FDA) for the treatment of vancomycin-resistant Enterococcus faecium infections, nosocomial and community-acquired pneumonia, as a part of anti tubercular regimen and com...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type：

    doi：10.1111/jcpt.13069

    authors： Singhania SVK,Shenoy S,Kapoor D

    更新日期：2020-04-01 00:00:00

  • Study of microbial contamination and dosing accuracy of oral dispensers.

    abstract：BACKGROUND AND OBJECTIVE:The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment of infants and children, as well as elderly people, who are more sensitive to dosage errors. Previous studies revealed significant dosage inaccuracies with measuring...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.2009.01082.x

    authors： Dockhorn S,Feuersenger D,Schuenemann S,Knauf B,Duerr S,Schubert-Zsilavecz M,Abdel-Tawab M

    更新日期：2010-06-01 00:00:00

  • The use of prescription drugs among elderly Finnish men.

    abstract：:The extent and factors that influence drug use were studied in two rural cohorts of Finnish men. The men aged between 65 and 84 years belonged to the Finnish study population of the 25-year follow-up of the 'Seven Countries Study'. Of the original 1,711 men in 1959, 766 were still alive in 1984. The participation rate...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2710.1990.tb00365.x

    authors： Enlund H,Martikainen J,Turakka H,Nissinen A

    更新日期：1990-04-01 00:00:00

  • Fatal interstitial lung disease induced by rituximab-containing chemotherapy, treatment with TNF-α antagonist and cytokine profiling: a case-report and review of the literature.

    abstract：WHAT IS KNOWN AND OBJECTIVE:Rituximab, an anti-CD20 monoclonal antibody, is widely used with good response for the treatment of B-cell lymphoma and various refractory autoimmune diseases. Although rituximab is effective, rare but serious pulmonary adverse reactions have been reported. We report on a case of rituximab-i...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1111/jcpt.12052

    authors： Wu Y,Jia Y,Xu J,Shuai X,Wu Y

    更新日期：2013-06-01 00:00:00

  • CYP2D6 phenotypes among Malays in Malaysia.

    abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

    journal_title：Journal of clinical pharmacy and therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2710.2000.00304.x

    authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

    更新日期：2000-10-01 00:00:00