Population analysis for the optimization of digoxin treatment in Japanese paediatric patients.

Abstract:

BACKGROUND AND OBJECTIVES:Information about the pharmacokinetics of digoxin in paediatric patients is limited. We therefore aimed to investigate the effects of physiological factors on the digoxin clearance in Japanese paediatric patients. METHOD:We used routinely collected therapeutic drug monitoring data (n=544), derived from the steady-state serum concentrations of digoxin in 181 hospitalized paediatric patients. RESULTS:Of those physiological factors which have been examined in this study, age and total body weight were most closely correlated with digoxin clearance. Data on neonates within the first postnatal month indicated a tendency towards lower clearance for premature neonates than full-term neonates (P<0.01). Digoxin clearance was reduced by spironolactone in patients younger than 4 months (P<0.05). Patients with congestive heart failure showed a lower digoxin clearance than the others (P<0.001). Serum creatinine and gender did not have a statistically significant effect on digoxin clearance. CONCLUSION:Age and total body weight are important factors influencing digoxin clearance in children. Spironolactone affected digoxin clearance and needs to be considered when dosing paediatric subjects.

journal_name

J Clin Pharm Ther

authors

Suematsu F,Minemoto M,Yukawa E,Higuchi S

doi

10.1046/j.1365-2710.1999.00221.x

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

203-8

issue

3

eissn

0269-4727

issn

1365-2710

journal_volume

24

pub_type

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