The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy.


WHAT IS KNOWN AND OBJECTIVE:6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (ciclopirox) and specifically its olamine salt 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone 2-aminoethanol salt (ciclopirox olamine) are anti-fungal agents currently used for the treatment of mild to moderate cutaneous fungal infection. Our objective is to comment on the opportunity to rapidly reposition ciclopirox and its olamine for the treatment of haematologic malignancy by leveraging its prior published toxicology and pharmacology data. COMMENT:Ciclopirox olamine chelates intracellular iron and displays preclinical efficacy in the treatment of haematologic malignancy. Currently, an ongoing study is evaluating topical ciclopirox olamine for the treatment of cervical cancer. Doses of ciclopirox olaine required for a systemic anti-cancer effect appear pharmacologically achievable. However, caution is required as at the highest doses tested in animal toxicology studies, irreversible cardiac degeneration was observed. WHAT IS NEW AND CONCLUSION:The existing pharmacology and toxicology data suggest that systemic ciclopirox olamine could be repositioned as a new investigational anti-cancer agent. The available pharmacology and toxicology data should aid in the design of phase I clinical trials of this agent in patients with refractory haematologic malignancies.


J Clin Pharm Ther


Weir SJ,Patton L,Castle K,Rajewski L,Kasper J,Schimmer AD




Has Abstract


2011-04-01 00:00:00












  • What do the suffixes--XR, ER, Chrono, Chronosphere--really mean as it pertains to modified-release antiepileptic drugs?

    abstract:BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Reed RC,Meinhold J,Dutta S,Liu W,Qiu Y

    更新日期:2010-08-01 00:00:00

  • Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion.

    abstract:BACKGROUND:The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability. OBJECTIVE:To assess the physical compatibility and the chemical stability of nefopam hydrochloride, a centrally acting non-opioid analgesic, when admixed with selected proton pump inhibit...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Kambia NK,Luyckx M,Dine T,Dupin-Spriet T,Gressier B,Brunet C

    更新日期:2009-02-01 00:00:00

  • Linezolid and the risk of lactic acidosis: Data mining and analysis of the FDA Adverse Event Reporting System.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Lactic acidosis (LA) is a rare but potentially lethal side effect of linezolid (LZD). However, limited by the study population, the number of patients with LA is insufficient to summarize all the clinical characteristics and risk factors. METHODS:We evaluated the association between LZD and...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Dai Y,Wang Y,Zeng Y,Zhang C,Zhou Z,Shi D

    更新日期:2020-12-01 00:00:00

  • Investigation of urinary levels of salbutamol in asthmatic patients receiving inhaled therapy.

    abstract:AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Jacobson GA,Peterson GM,McLean S

    更新日期:1997-04-01 00:00:00

  • Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S

    更新日期:2011-04-01 00:00:00

  • Use of Tris-hydroxymethyl aminomethane in severe lactic acidosis due to highly active antiretroviral therapy: a case report.

    abstract:BACKGROUND:Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HI...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Marfo K,Garala M,Kvetan V,Gasperino J

    更新日期:2009-02-01 00:00:00

  • Efficacy and safety of gabapentin 1800 mg treatment for post-herpetic neuralgia: a meta-analysis of randomized controlled trials.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Gabapentin has been used for the management of post-herpetic neuralgia (PHN). However, inconsistent results have been reported. This meta-analysis was performed to assess the efficacy and safety of gabapentin 1800 mg/day in PHN patients by conducting a meta-analysis. METHODS:Electronic data...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Fan H,Yu W,Zhang Q,Cao H,Li J,Wang J,Shao Y,Hu X

    更新日期:2014-08-01 00:00:00

  • Analysis of clinical characteristics of tigecycline-induced acute pancreatitis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The purpose of this study is to explore the clinical characteristics of tigecycline-induced acute pancreatitis. METHODS:We searched the PubMed/Medline, Web of Knowledge, OVID, Elsevier, Springer Link, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, an...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Fang W,Yi D,Sun L,Wang C

    更新日期:2020-12-01 00:00:00

  • Drug-use pattern of Chinese herbal medicines in insomnia: a 4-year survey in Taiwan.

    abstract:BACKGROUND AND OBJECTIVE:Insomnia is a common complaint in the general population. Interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in Taiwan. We undertook a survey to define the drug utilization patterns of Chinese herbal medicines (CM) for insomnia in Taiwan....

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Chen LC,Chen IC,Wang BR,Shao CH

    更新日期:2009-10-01 00:00:00

  • Randomized trial comparing efficacies of zoledronate and alendronate for improving bone mineral density and inhibiting bone remodelling in women with post-menopausal osteoporosis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Bisphosphonates are the first-line medications for treating osteoporosis. The aim of our prospective study was to compare the efficacy of zoledronate with that of alendronate in women with post-menopausal osteoporosis based on the evaluations of bone mineral density (BMD) and serum levels of...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Tan W,Sun J,Zhou L,Li Y,Wu X

    更新日期:2016-10-01 00:00:00

  • Theophylline plasma clearance in critically ill geriatric patients receiving total parenteral nutrition and in control patients.

    abstract::Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patien...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Sangrador G,Sánchez-Alcaraz A,Ubeda R,Ibañez P

    更新日期:1990-08-01 00:00:00

  • Exploration of optimal dosing regimens of vancomycin in patients infected with methicillin-resistant Staphylococcus aureus by modeling and simulation.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

    更新日期:2014-04-01 00:00:00

  • Efficacy of adjuvant dexmedetomidine in supraclavicular brachial plexus block for intractable complex regional pain syndrome: A case report with a 3-year follow-up.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Pain management for complex regional pain syndrome (CRPS) is challenging. When added to local anaesthetics, dexmedetomidine prolongs the duration of the block and improves analgesia. The effect of long-term dexmedetomidine use in the brachial plexus block (BPB) for CRPS is unknown. CASE DES...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Kang SH,Sim WS,Park HJ,Moon JY,Seon HJ,Lee JY

    更新日期:2020-04-01 00:00:00

  • Sleep quality and the use of benzodiazepine hypnotics in general practice.

    abstract::The aim of the study was to determine the usage patterns of benzodiazepine hypnotics, the use of other ways of improving sleep and general sleep characteristics in patients prescribed these drugs on a regular basis and in a control group of age- and sex-matched patients not receiving hypnotics. Patients receiving regu...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Krska J,MacLeod TN

    更新日期:1995-04-01 00:00:00

  • Clinical factors associated with hyperkalemia in patients with congestive heart failure.

    abstract:BACKGROUND:Patients with congestive heart failure (CHF) are at risk for hyperkalemia because of coexisting comorbidities and use of multiple medications that impair potassium (K) excretion such as angiotensin converting enzyme (ACE) inhibitors. OBJECTIVE:To identify clinical factors associated with hyperkalemia on ini...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Ramadan FH,Masoodi N,El-Solh AA

    更新日期:2005-06-01 00:00:00

  • A drug usage review of omeprazole.

    abstract::A drug use review of omeprazole was carried out at two centres in the Yorkshire Region from December 1990 to April 1991. Data collection documents were used and 66 patients in total were audited. Thirteen patients (19.7%) were treated for indications outside the product licence and 18 patients (27.3%) were treated for...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Norris CM,McManus PV,Petty D,Kay EA

    更新日期:1992-12-01 00:00:00

  • Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, ...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Martin CS,Blaga C,Lambrescu IM,Fierbințeanu-Braticevici C,Fica S

    更新日期:2015-10-01 00:00:00

  • Population analysis for the optimization of digoxin treatment in Japanese paediatric patients.

    abstract:BACKGROUND AND OBJECTIVES:Information about the pharmacokinetics of digoxin in paediatric patients is limited. We therefore aimed to investigate the effects of physiological factors on the digoxin clearance in Japanese paediatric patients. METHOD:We used routinely collected therapeutic drug monitoring data (n=544), de...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Suematsu F,Minemoto M,Yukawa E,Higuchi S

    更新日期:1999-06-01 00:00:00

  • Microbial contamination and preservative efficacy of topical creams.

    abstract::Nineteen different brands of topical creams were tested in duplicate for microbial growth. The efficacy of their preservation was assessed, when possible, by standard pharmacopoeial procedures. Microbial growth was demonstrated in cultures from all specimens. However, high counts (> 10(4) c.f.u./g) were obtained from ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Na'was T,Alkofahi A

    更新日期:1994-02-01 00:00:00

  • Particulate contamination of lyophilized amphotericin B preparation during reconstitution process.

    abstract:OBJECTIVE:To investigate the effect of the reconstitution methods for the commercial amphotericin B preparation with respect to particulate contamination. METHODS:The particle counts in amphotericin B solutions reconstituted according to three different methods and amphotericin B fluids made with intravenous fluids af...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Sendo T,Hirakawa M,Makino K,Nakashima K,Kataoka Y,Oishi R

    更新日期:2001-04-01 00:00:00

  • Computerized pharmaceutical intervention to reduce reconciliation errors at hospital discharge in Spain: an interrupted time-series study.

    abstract:WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: García-Molina Sáez C,Urbieta Sanz E,Madrigal de Torres M,Vicente Vera T,Pérez Cárceles MD

    更新日期:2016-04-01 00:00:00

  • Antibiotic prescribing practices in primary and secondary health care facilities in Uttar Pradesh, India.

    abstract:BACKGROUND:Emerging antibiotic resistance in common pathogens is a worldwide problem known to be related to inappropriate overuse of antibiotics. Wide variability in antibiotic use throughout the world is because of various factors, including socio-cultural differences. OBJECTIVE:To study the rate of antibiotic prescr...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Kumar R,Indira K,Rizvi A,Rizvi T,Jeyaseelan L

    更新日期:2008-12-01 00:00:00

  • Exacerbation of psoriatic skin lesions in a patient with psoriatic arthritis receiving adalimumab.

    abstract:OBJECTIVE:To report a case of a patient with psoriatic arthritis (PsA) receiving adalimumab, who developed an exacerbation of palmoplantaris pustulosa psoriasis. CASE SUMMARY:A 38-year-old woman diagnosed with PsA had received treatment with non-steroidal antiinflammatory drugs. Two months prior to admission, the pati...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Borrás-Blasco J,Gracia-Perez A,Nuñez-Cornejo C,Rosique-Robles JD,Mateu-Puchades A,Casterá MD,Rubio-Fabra M

    更新日期:2008-06-01 00:00:00

  • Decitabine prior to salvaged cord blood transplantation for acute myeloid leukaemia/myelodysplastic syndrome not in remission.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Many refractory/relapsed haematological malignancies, in non-remission state, still have poor prognosis even after allogeneic haematopoietic stem cell transplantation. Recently, decitabine or umbilical cord blood transplantation (UCBT) seemed to be effective in these patients. However, few s...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Yao W,Chu X,Fang X,Zhu X,Tang B,Wan X,Geng L,Tong J,Song K,Zhang X,Qiang P,Sun G,Liu H,Sun Z

    更新日期:2020-12-01 00:00:00

  • Aminoglycoside pharmacokinetics in African-Americans with normal renal function.

    abstract:OBJECTIVE:To compare aminoglycoside pharmacokinetics in African-Americans with normal renal function with published adult population values. DESIGN:An Institutional Review Board approved concurrent study. SETTING:The study was conducted at Howard University Hospital, Washington DC. SUBJECTS:All subjects had serum cr...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Oparaoji EC,Siram S,Elemihe U,Mezghebe HM,Cho T,Bashiri M,Piedrahita K,Pipalla RS

    更新日期:1998-06-01 00:00:00

  • Treatment of irritable bowel syndrome.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The complexity and diversity of irritable bowel syndrome's (IBS) presentation make treatment difficult. Although there are reviews and guidelines for treating IBS, they focus on the efficacy of medications for IBS symptoms using high-priority endpoints, leaving those of lower priority largel...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Trinkley KE,Nahata MC

    更新日期:2011-06-01 00:00:00

  • Effect of various estimates of renal function on prediction of vancomycin concentration by the population mean and Bayesian methods.

    abstract:OBJECTIVE:Renal function was estimated in 129 elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) who were treated with vancomycin (VCM). The estimation was performed by substituting serum creatinine (SCR) measured enzymatically and a value converted using the Jaffe method into the Cockcroft-Gault ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Tsuji Y,Hiraki Y,Mizoguchi A,Sadoh S,Sonemoto E,Kamimura H,Karube Y

    更新日期:2009-08-01 00:00:00

  • Extremely low dose of 6-mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations.

    abstract:WHAT IS KNOWN AND OBJECTIVES:Thiopurines are cornerstone drugs in the treatment of acute lymphoblastic leukaemia (ALL), but their use can be complicated by the incidence of life-threatening leucopenia. CASE DESCRIPTION:We describe a case of a 6-year-old Chinese boy with B-ALL receiving extremely low dose of 6-mercapto...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Zhai XY,Zhou Y,Dong L,Nie AQ,Zhi LJ,Jacqz-Aigrain E,Wang TY,Wang L,Zhao W

    更新日期:2021-02-01 00:00:00

  • Trends in pharmacists' medication order review in French hospitals from 2006 to 2009: analysis of pharmacists' interventions from the Act-IP© website observatory.

    abstract:WHAT IS KNOWN AND OBJECTIVES:The French Society of Clinical Pharmacy has developed a website, named Act-IP©, enabling hospital pharmacists to document and analyse pharmacists' interventions (PIs) proposed during medication order review when a drug-related problem is detected. This study analyses PIs documented in Act-I...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Bedouch P,Sylvoz N,Charpiat B,Juste M,Roubille R,Rose FX,Bosson JL,Conort O,Allenet B,French Society of Clinical Pharmacy's Act-IP© Group.

    更新日期:2015-02-01 00:00:00

  • Stability of vancomycin in plastic syringes measured by high-performance liquid chromatography.

    abstract::The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickins...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Wood MJ,Lund R,Beavan M

    更新日期:1995-12-01 00:00:00