Abstract:
WHAT IS KNOWN AND OBJECTIVE:6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (ciclopirox) and specifically its olamine salt 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone 2-aminoethanol salt (ciclopirox olamine) are anti-fungal agents currently used for the treatment of mild to moderate cutaneous fungal infection. Our objective is to comment on the opportunity to rapidly reposition ciclopirox and its olamine for the treatment of haematologic malignancy by leveraging its prior published toxicology and pharmacology data. COMMENT:Ciclopirox olamine chelates intracellular iron and displays preclinical efficacy in the treatment of haematologic malignancy. Currently, an ongoing study is evaluating topical ciclopirox olamine for the treatment of cervical cancer. Doses of ciclopirox olaine required for a systemic anti-cancer effect appear pharmacologically achievable. However, caution is required as at the highest doses tested in animal toxicology studies, irreversible cardiac degeneration was observed. WHAT IS NEW AND CONCLUSION:The existing pharmacology and toxicology data suggest that systemic ciclopirox olamine could be repositioned as a new investigational anti-cancer agent. The available pharmacology and toxicology data should aid in the design of phase I clinical trials of this agent in patients with refractory haematologic malignancies.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Weir SJ,Patton L,Castle K,Rajewski L,Kasper J,Schimmer ADdoi
10.1111/j.1365-2710.2010.01172.xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
128-34issue
2eissn
0269-4727issn
1365-2710journal_volume
36pub_type
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journal_title:Journal of clinical pharmacy and therapeutics
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doi:10.1111/j.1365-2710.2006.00742.x
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abstract:WHAT IS KNOWN AND OBJECTIVE:Neuraminidase inhibitors are important options for the treatment of infection by the influenza virus. For the treatment of severe influenza, parenteral administration of a neuraminidase inhibitor may be desirable. This study was conducted to evaluate the pharmacokinetic and safety profiles o...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpt.12056
更新日期:2013-06-01 00:00:00
abstract::We examined a total of 192 samples, including eight different brands of shaving cream and eight brands of shampoo, for their total aerobic bacterial, coliforms and fungal counts. Shaving creams were more heavily contaminated with bacteria than shampoos. Viable bacterial were not recovered from 57% and 10% of shampoos ...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.1989.tb00218.x
更新日期:1989-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic e...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2010.01224.x
更新日期:2011-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMME...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12691
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1046/j.1365-2710.2000.00304.x
更新日期:2000-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:With the ageing of the population also comes increasing comorbidities and the use of multiple medications and administration methods, along with greater susceptibility to adverse drug reactions. Dosage form modification to facilitate drug administration in older adults can be potentially pro...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12822
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:A descriptive study of national sales data from Sweden to find out the effect of over-the-counter (OTC) switches on total sales of a number of drugs. During the period 1980-94, 16 drugs were changed from prescription only (Rx) status to the Swedish OTC market. Total sales increased for 14 out of these 16 drug...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.1996.tb00042.x
更新日期:1996-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...
journal_title:Journal of clinical pharmacy and therapeutics
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abstract:WHAT IS KNOWN AND OBJECTIVE:An imbalance in the genetically controlled pro- and anti-inflammatory cytokine production could potentially promote ongoing low-grade inflammation following an episode of acute gastroenteritis and, subsequently, could result in irritable bowel syndrome (IBS; post-infectious IBS, PI-IBS). Sin...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12775
更新日期:2019-04-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12164
更新日期:2014-08-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. CASE DESCRIPTION:We present two cases of Lemierr...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.12774
更新日期:2019-02-01 00:00:00
abstract::Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally acce...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2710.2008.00961.x
更新日期:2008-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.13162
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Although the elimination half-life of most glucocorticoids is short, they are usually administered once daily, or even on alternate days. Our hypothesis was that this practice might compromise the immunosuppressive effect of those drugs during the second part of the administration interval. METHODS:Eight hea...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-2710.2002.00422.x
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2009.01087.x
更新日期:2013-02-01 00:00:00
abstract::A hypertensive crisis can be caused by many factors. Frequently, the mechanism involved is complex and highly variable among patients. Without drug therapy, this condition is associated with very high mortality and morbidity. There are a number of oral and intravenous hypotensive agents available, which can effectivel...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2710.1994.tb00669.x
更新日期:1994-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Inhaled treprostinil represents an attractive alternative to the other available prostacyclin formulations by obviating the use of continuous infusions and its associated risks. Published evidence describing the process of transition from infusion prostacyclin therapy to inhaled treprostinil...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12170
更新日期:2014-10-01 00:00:00
abstract::Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffe...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2710.1995.tb00621.x
更新日期:1995-02-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Ticagrelor is a reversibly binding and selective P2Y12 -receptor antagonist approved for the prevention of atherothrombotic events in patients with acute coronary syndromes. As bleeding events remain a hazard with antiplatelet therapy, this study investigated the effect of the vasopressin ag...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpt.12130
更新日期:2014-04-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:One-third of patients with epilepsy are resistant to anti-epileptic drugs (AEDs). Drug-resistant epilepsy is believed to be multifactorial involving both genetic and non-genetic factors. Genetic variations in the ABCB1 gene encoding the drug efflux transporter, p-glycoprotein (p-gp), may inf...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.12263
更新日期:2015-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Fluconazole is an antifungal agent that is commonly used to treat patients with serious systemic fungal infections in intensive care units. Fosfluconazole is a phosphate prodrug of fluconazole, which was developed to reduce the volume of fluid required to administer fluconazole by intravenou...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2011.01297.x
更新日期:2012-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.12403
更新日期:2016-08-01 00:00:00
abstract::The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2710.2000.00260.x
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Upregulation of oligopeptide transport activity by dietary protein, certain dipeptides and amino acids has been reported in the rat intestine and a human intestinal cell line. OBJECTIVE:In this study, the pharmacokinetics of cefdinir were investigated after L-phenylalanine supplementation and a high-protein...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2710.2007.00826.x
更新日期:2007-06-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radia...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,meta分析,评审
doi:10.1111/jcpt.12498
更新日期:2017-04-01 00:00:00
abstract::When assessing a health-care intervention the main question is--does it work? Often, a more difficult question needs to be answered--how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking,...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2710.1996.89275892.x
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1046/j.1365-2710.2000.00310.x
更新日期:2000-12-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. CASE SUMMARY:We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium afte...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type:
doi:10.1111/jcpt.13116
更新日期:2020-10-01 00:00:00
abstract:WHAT IS KNOWN AND OBJECTIVE:There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/jcpt.13202
更新日期:2020-12-01 00:00:00