Abstract:
WHAT IS KNOWN AND OBJECTIVE:Antibiotic resistance has become a global public health issue. Most antibiotics are prescribed in the community, although there is less stewardship of such agents in the community compared to secondary and tertiary care. Few studies have attempted to examine the prescribing practices in General Practice and its impact on antibiotic resistance and, therefore, a study was performed in order to compare antibiotic susceptibilities of commensal viridans group streptococci (VGS) obtained from patient cohorts in General Practices (GP), who were high and low prescribers of oral antibiotics. METHOD:Sixty-five patients (<1 month-81 years; 77% female: 23% male) were enrolled onto the study, and viridans group streptococci (n = 5/patient) were collected from each patient's nasal passages and oropharynx region and tested for antibiotic susceptibility against (i) tetracyclines (doxycycline); (ii) macrolides (erythromycin); (iii) β-lactams (penicillin G); and (iv) fluoroquinolones (ofloxacin & levofloxacin). RESULTS AND DISCUSSION:There were no significant differences in MICs between high and low GP prescribers with doxycycline (P = 0·094), erythromycin (P = 0·122), ofloxacin (P = 0·193) and levofloxacin (P = 0·058). However, there was a significant difference between high and low GP practices with regard to penicillin G (P = 0·031). This finding is important as the β-lactams are the most commonly prescribed oral antibiotic in the community. WHAT IS NEW AND CONCLUSION:This study demonstrates that high prescribing practices may lead to an altered (higher) level of resistance to these agents in the commensal VGS population, which may be important as reservoirs of antibiotic resistance determinants in subsequent horizontal gene transfer events, particularly with newly colonizing pathogens, including pneumococci. Primary care physicians should be aware that increased prescribing of antibiotics may led to increased level of penicillin resistance.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Goldsmith CE,Hara Y,Sato T,Nakajima T,Nakanishi S,Mason C,Moore JE,Matsuda M,Coulter WAdoi
10.1111/jcpt.12245subject
Has Abstractpub_date
2015-04-01 00:00:00pages
204-7issue
2eissn
0269-4727issn
1365-2710journal_volume
40pub_type
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of clinical pharmacy and therapeutics
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pub_type: 杂志文章,meta分析
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journal_title:Journal of clinical pharmacy and therapeutics
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doi:10.1111/j.1365-2710.1992.tb01262.x
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章,评审
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更新日期:1993-02-01 00:00:00
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journal_title:Journal of clinical pharmacy and therapeutics
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.1987.tb00543.x
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