Abstract：
WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's syndrome affected by pinworms infestation. CASE SUMMARY:Differently from other cases of hepatitis due to MBZ reported in the scientific literature, our patient received standard doses of MBZ for a short period of time. After 18 days from the start of therapy, he developed hepatomegaly, and increases in hepatic enzymes and bilirubin. Hepatic enzymes returned to normal over the following 5 weeks. WHAT IS NEW AND CONCLUSION:This is the first case report of important liver injury after administration of MBZ in a patient with Gilbert's syndrome. We suspected that a diminished hepatic glucuronidation of MBZ due to the reduced activity of the glucuronosyltransferase enzyme in our patient could have caused an increase in unconjugated toxic metabolites of MBZ and the consequent liver damage.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Tolomeo M,Colomba C,Meli M,Cascio Adoi
10.1111/jcpt.13033subject
Has Abstractpub_date
2019-12-01 00:00:00pages
985-987issue
6eissn
0269-4727issn
1365-2710journal_volume
44pub_type
abstract：WHAT IS KNOWN AND OBJECTIVE:The calcium channel blocker diltiazem has been used widely as a cyclosporine (CsA)/tacrolimus-sparing agent. However, considerable interpatient variability in diltiazem's CsA/tacrolimus-sparing effect has been observed in many clinical studies. This study was carried out to investigate the i...
journal_title：Journal of clinical pharmacy and therapeutics
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journal_title：Journal of clinical pharmacy and therapeutics
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journal_title：Journal of clinical pharmacy and therapeutics
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journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章
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journal_title：Journal of clinical pharmacy and therapeutics
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1111/j.1365-2710.2003.00541.x
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journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
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journal_title：Journal of clinical pharmacy and therapeutics
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abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...
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journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
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