Abstract：
:Enalapril was shown to have no effect on the serum potassium of patients (n = 16) already taking Frusemide and Amiloride. Furthermore, there was no difference in serum potassium levels of the group taking a combination of Enalapril, Frusemide and Amiloride when compared to a similar group of patients taking Frusemide and Amiloride alone (n = 19). No patients in either group were deemed to have seriously impaired renal function. The results indicate that the theoretical hyperkalaemic effect of concurrent administration of Enalapril and Amiloride is not manifest in clinical practice in patients with normal renal function.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Radley AS,Fitzpatrick RWdoi
10.1111/j.1365-2710.1987.tb00543.xsubject
Has Abstractpub_date
1987-10-01 00:00:00pages
319-23issue
5eissn
0269-4727issn
1365-2710journal_volume
12pub_type
杂志文章abstract：WHAT IS KNOW AND OBJECTIVE:Teriflunomide is indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis. CASE SUMMARY:We present a rare intoxication with a high dose (672 mg) of teriflunomide. According to its product label, the only known treatment is the administration of colestyramine ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13360
更新日期：2021-01-09 00:00:00
abstract：:Very few studies have been carried out looking at how the effects of drugs and their toxicity in humans change during their lifespan (developing and ageing). The purpose of this study is to review the literature on the changes in probe-drug metabolism, classified by cytochrome P450 (P450 or CYP) at five stages in life...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.1998.00164.x
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:The quality of 33 formulations of essential antimicrobial and antimalarial drugs (amoxicillin capsules, metronidazole tablets, sulfamethoxazole/trimethoprim tablets, quinine tablets and sulphadoxine/pyrimethamine tablets) marketed in Rwanda and Tanzania was assessed and the influence of tropical storage condi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2004.00568.x
更新日期：2004-08-01 00:00:00
abstract：:This study investigated chemical and pharmaceutical equivalence of 11 brands of pyrimethamine-sulphadoxine combination tablets sold on the Tanzanian market. Physical and chemical tests were performed for all the 11 brands. These tests included hardness test, friability, disintegration, dissolution, weight uniformity a...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2005.00687.x
更新日期：2005-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Pain management for complex regional pain syndrome (CRPS) is challenging. When added to local anaesthetics, dexmedetomidine prolongs the duration of the block and improves analgesia. The effect of long-term dexmedetomidine use in the brachial plexus block (BPB) for CRPS is unknown. CASE DES...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13063
更新日期：2020-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Bisphosphonates are the first-line medications for treating osteoporosis. The aim of our prospective study was to compare the efficacy of zoledronate with that of alendronate in women with post-menopausal osteoporosis based on the evaluations of bone mineral density (BMD) and serum levels of...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12429
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00999.x
更新日期：2009-06-01 00:00:00
abstract：:Nineteen different brands of topical creams were tested in duplicate for microbial growth. The efficacy of their preservation was assessed, when possible, by standard pharmacopoeial procedures. Microbial growth was demonstrated in cultures from all specimens. However, high counts (> 10(4) c.f.u./g) were obtained from ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1994.tb00808.x
更新日期：1994-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The CHOP regimen with rituximab (R-CHOP) remains the standard for chemotherapy in patients with aggressive non-Hodgkin's lymphoma (NHL). The cardiotoxicity of doxorubicin appears to be a key problem in clinical practice. We studied the cardiotoxicity of CHOP/R-CHOP regimen in a retrospective...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12124
更新日期：2014-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:There are no clinical reports that have compared topiroxostat, a selective xanthine oxidase inhibitor, with allopurinol in serum urate-lowering efficacy. The aim of this study was to compare the efficacy and safety of topiroxostat and allopurinol in Japanese hyperuricemic patients with or wi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/jcpt.12391
更新日期：2016-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. CASE SUMMARY:We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium afte...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13116
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To report three cases of alopecia induced by the anticoagulant enoxaparin in cerebral venous thrombosis (CVT) patients. CASE SUMMARY:Three female patients were treated initially with direct intrasinus urokinase, and then followed by low-molecular-weight heparin (LMWH) enoxaparin at 1 mg/kg given subcutaneous...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2006.00769.x
更新日期：2006-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12538
更新日期：2017-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The most common complication of heparin therapy is bleeding. Allergic reactions to heparin are rare, and the mechanisms are poorly understood. We report on a case of acute systemic reaction after subcutaneous injections of a low-molecular-weight heparin (LMWH) in a patient with a genetic pre...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2710.2012.01360.x
更新日期：2012-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Long non-coding RNAs (lncRNAs) have been proved to regulate. LncRNA TUG1 is well characterized in cancer biology. This study was carried out to investigate the molecular function of lncRNA TUG1 in myocardial infarction. METHODS:This study enrolled 58 MI patients and 52 healthy volunteers, a...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13190
更新日期：2020-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12047
更新日期：2013-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:This study developed a population pharmacokinetic (PK) model of levetiracetam (LEV) for treating neonatal seizures (NS) and determined the influence of clinically relevant covariates to explain the interindividual variability and residual error. METHODS:Twenty newborns admitted to the Neona...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12658
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data. METHOD:The steady-state blood level data (n = 129) after repetitive oral administration in 71 hospitalized neonates were analysed using Nonlinear Mixed Effects Modellin...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2007.00833.x
更新日期：2007-08-01 00:00:00
abstract：:The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n = 50) or active ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2710.2002.00439.x
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To report a case of a patient with psoriatic arthritis (PsA) receiving adalimumab, who developed an exacerbation of palmoplantaris pustulosa psoriasis. CASE SUMMARY:A 38-year-old woman diagnosed with PsA had received treatment with non-steroidal antiinflammatory drugs. Two months prior to admission, the pati...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00915.x
更新日期：2008-06-01 00:00:00
abstract：:Drug infusions can be exposed for prolonged periods to 'in-use' conditions where the temperature of an infusion in a holster-worn infusion pump may reach 37 degrees C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5-fluorouracil and mitozantrone) and one analgesic infusion (diamorphine H...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1991.tb00293.x
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2000.00310.x
更新日期：2000-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12358
更新日期：2016-06-01 00:00:00
abstract：:Antimicrobials are frequently used to prevent infections. Principles of prophylaxis, and antimicrobial prophylaxis in surgery, tuberculosis, acquired immunodeficiency syndrome, influenza A, traveller's diarrhoea, malaria, recurrent otitis media, Haemophilus influenzae type b infection, pertussis, rheumatic fever, and ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1996.tb01147.x
更新日期：1996-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical pharmacokinetic profiles of clarithromycin and telithromycin in bronchopulmonary sites have not been fully characterized. This study aimed to describe in more detail the pharmacokinetics of the two macrolides in epithelial lining fluid (ELF) of human bronchi and to evaluate their ph...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12157
更新日期：2014-08-01 00:00:00
abstract：:The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study wi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2710.1994.tb01121.x
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVE:There is a growing interest in investigating the role of glutamate receptors in the pathophysiology of schizophrenia. Indeed, the hyperdopaminergic theory of schizophrenia can explain only the positive symptoms of schizophrenia, whereas the glutamate hypothesis may provide a more comprehensive view of the ill...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2710.1999.00238.x
更新日期：1999-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Fluconazole is an antifungal agent that is commonly used to treat patients with serious systemic fungal infections in intensive care units. Fosfluconazole is a phosphate prodrug of fluconazole, which was developed to reduce the volume of fluid required to administer fluconazole by intravenou...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2011.01297.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00910.x
更新日期：2008-06-01 00:00:00
abstract：:Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metaboliz...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,评审
doi：10.1111/j.1365-2710.1991.tb00288.x
更新日期：1991-04-01 00:00:00
