Abstract：
:Nineteen different brands of topical creams were tested in duplicate for microbial growth. The efficacy of their preservation was assessed, when possible, by standard pharmacopoeial procedures. Microbial growth was demonstrated in cultures from all specimens. However, high counts (> 10(4) c.f.u./g) were obtained from eight specimens from six different brands. The microbes were found to belong to different species of bacteria and fungi including Pseudomonas aeruginosa. Two samples of each of the seven, easily emulsifiable creams, were challenged with standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans to assess the efficacy of the preservatives used in their preparations. With the exception of a single brand, all creams tested were ineffectively preserved. This study highlights the dangers of marketing domestically prepared topical creams and more effective monitoring of the components for all topical creams is recommended. The inclusion of a proper preservative system in these formulas is essential.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Na'was T,Alkofahi Adoi
10.1111/j.1365-2710.1994.tb00808.xsubject
Has Abstractpub_date
1994-02-01 00:00:00pages
41-6issue
1eissn
0269-4727issn
1365-2710journal_volume
19pub_type
杂志文章abstract：:Flurbiprofen is a propionic acid-derived non-steroidal anti-inflammatory drug (NSAID) used widely in the treatment of rheumatism and non-arthritic pain. The pharmacokinetics of topically and orally administered flurbiprofen were compared in a two-part, open study involving healthy adult volunteers. In the first (cross...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2710.1995.tb00636.x
更新日期：1995-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:New first-in-class (FIC) drugs with novel mechanisms of action may be highly effective, but lack adequate safety information, and therefore may be associated with crucial post-marketing safety issues. The objective of this study was to evaluate the post-marketing risk of FIC drug with compar...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13096
更新日期：2020-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12365
更新日期：2016-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication sho...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12371
更新日期：2016-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12358
更新日期：2016-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Pulmonary sarcomatoid carcinoma (PSC) is characterized by dismal prognosis and resistance to platinum-based chemotherapy. The immune checkpoint inhibitors showed promising efficacy in the treatment of PSC. Camrelizumab is a programmed cell death protein 1 inhibitor; however, current evidence...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13234
更新日期：2020-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Drug prescribing is an essential part of inpatient care, and prescription errors/omissions have the potential to lead to disastrous consequences. Paediatric inpatient prescribing is particularly sensitive to error due to the weight-adjusted dosing of many medications prescribed in the acute ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12114
更新日期：2014-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12403
更新日期：2016-08-01 00:00:00
abstract：:A study was conducted in two groups of healthy volunteers to assess whether the time of administration (10 min before the meal versus 60 min after the meal) influences the pharmacokinetics and absorption kinetics of a slow-release theophylline product (Teonova). In the first group (Group A, n = 10), the drug was given...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2710.1988.tb00509.x
更新日期：1988-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Glucagon-like peptide-1 (GLP-1) receptor agonists delay gastric and bowel emptying. A similar inhibitory effect of GLP-1 on gallbladder motility has been suggested, possibly leading to an increased risk of cholecystitis related to incretin-based medications, which include GLP-1 antagonists. ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/jcpt.12373
更新日期：2016-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Based on extrapolation, biosimilar infliximab (IFX) was approved to treat inflammatory bowel disease (IBD). The first studies in adults have shown similar efficacy and safety in comparison with reference drug. The aim of this review was to collect and evaluate all the literature data regardi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/jcpt.13239
更新日期：2020-12-01 00:00:00
abstract：:Parenterals, sterile preparations intended to be injected in man or animal, should be free from pyrogenic substances which are able to raise the thermostatic setting in the hypothalamus. This article gives an up-to-date review of the principal detection and quantification methods for these agents, with special attenti...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2710.1987.tb00531.x
更新日期：1987-08-01 00:00:00
abstract：:Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metaboliz...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,评审
doi：10.1111/j.1365-2710.1991.tb00288.x
更新日期：1991-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Teneligliptin is a DPP-4 inhibitor used for the treatment of type 2 diabetes mellitus, commonly prescribed in combination with glimepiride. Teneligliptin is metabolized by CYP3A4, and glimepiride might be partly metabolized by CYP3A4. The aim of the study was to investigate the possible effe...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12848
更新日期：2019-10-01 00:00:00
abstract：:Hyperprolactinemia is a frequent side-effect in the use of atypical antipsychotics. The propensity to induce hyperprolactinemia is highly substance dependent and hyperprolactinemia is not always associated with clinical side-effects. We report a case in which hyperprolactinemia and amenorrhea under the treatment with ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2007.00806.x
更新日期：2007-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12123
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To evaluate if once-daily dose (ODD) regimens of tobramycin attain pharmacodynamic goals using individualized pharmacokinetic monitoring of critically ill patients with creatinine clearance (Clcr) over 60 mL/min. METHODS:Fifty-one adult critically ill patients treated with intravenous tobramycin with ODD wer...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2003.00539.x
更新日期：2004-02-01 00:00:00
abstract：:The in vitro dissolution rates of 5 and 10 mg nifedipine capsules from eight suppliers were measured in simulated gastric fluid using the rotating paddle apparatus. A total of fourteen products were tested and the performance was found to be satisfactory for all products (> 80% dissolution in 20 min). ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1995.tb00656.x
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2002.00386.x
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:To determine whether patients who are prescribed a highly active antiretroviral therapy regimen, that minimizes medical and lifestyle contraindications, will be better able to adhere to their drug regimens and will have better clinical outcomes, than patients who do not have such a regimen. METHODS:A retrosp...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2006.00755.x
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2007.00842.x
更新日期：2007-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Current guidelines recommend a combination of clopidogrel and aspirin for management of patients who have experienced an acute coronary syndrome (ACS). Additional antiplatelet agents have been recently approved. Few comparative effectiveness studies are available for these new agents. Accord...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12209
更新日期：2014-12-01 00:00:00
abstract：:In many countries, including The Netherlands, little is known about the overall prescribing patterns within hospitals. While individual hospitals have some data available, these are not pooled on a regional or national level. The available data consist of dispensing data that are neither patient-linked nor diagnosis-l...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1991.tb00332.x
更新日期：1991-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Edoxaban has three dose adjustment factors (creatinine clearance, 15-50 mL/min; body weight, 60 kg or less; and concomitant medication with potent P-glycoprotein inhibitors) to prevent bleeding that results from elevated blood concentrations of the drug. A dose reduction (from 60 to 30 mg/da...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13065
更新日期：2020-04-01 00:00:00
abstract：:This study examined out-patients' interpretation of prescription instructions at a community hospital. The results showed a wide range of misinterpretation with respect to drug name, dose schedule, and auxiliary labels. Age level, education and financial status emerged as the most significant variables associated with...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1992.tb01280.x
更新日期：1992-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence. COMMENT:Although interethnic differences in drug response are well known, there are no reliable epid...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12768
更新日期：2019-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. Secondary forms of the disease may be due to consumption of trimethylamine precursor-rich foods or metabolism of some xenobiotics. CASE SUMMARY:A HI...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13315
更新日期：2020-11-28 00:00:00
abstract：:To dose the anticonvulsant phenytoin (PHT) in a clinical situation is difficult because of the non-linear metabolism of the drug. Therefore many techniques have been advocated to aid dosage adjustments based on a single-point PHT concentration determined at steady-state (ss). We retrospectively investigated six method...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1988.tb00196.x
更新日期：1988-08-01 00:00:00
abstract：:The aim of the study was to determine the usage patterns of benzodiazepine hypnotics, the use of other ways of improving sleep and general sleep characteristics in patients prescribed these drugs on a regular basis and in a control group of age- and sex-matched patients not receiving hypnotics. Patients receiving regu...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1995.tb00634.x
更新日期：1995-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical pharmacokinetic profiles of clarithromycin and telithromycin in bronchopulmonary sites have not been fully characterized. This study aimed to describe in more detail the pharmacokinetics of the two macrolides in epithelial lining fluid (ELF) of human bronchi and to evaluate their ph...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12157
更新日期：2014-08-01 00:00:00
