Heparin-induced acute adverse reaction--case report of a patient with acute trauma and a genetic predisposition to thrombotic events: a concurrence of events.

abstract：WHAT IS KNOWN AND OBJECTIVE:Chemotherapy can increase treatment-related mortality associated with future haematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukaemia (AML). There is usually insufficient time to find a suitable unrelated donor for these patients. We repor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang C,Chen XH,Liu J,Gao L,Liu Y,Gao L,Kong PY,Zhang X

更新日期：2015-06-01 00:00:00

abstract：:An information package was developed for general practitioners (GPs) involved in the management of home parenteral nutrition (HPN) patients. The booklet covered five major sections: background information; HPN training; complications of HPN; arrangements for a particular patient; and hospital management of HPN. This s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Malone M

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Although the elimination half-life of most glucocorticoids is short, they are usually administered once daily, or even on alternate days. Our hypothesis was that this practice might compromise the immunosuppressive effect of those drugs during the second part of the administration interval. METHODS:Eight hea...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Uhl A,Czock D,Boehm BO,Zellner D,Mertz A,Keller F

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To determine whether patients who are prescribed a highly active antiretroviral therapy regimen, that minimizes medical and lifestyle contraindications, will be better able to adhere to their drug regimens and will have better clinical outcomes, than patients who do not have such a regimen. METHODS:A retrosp...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lal LS,Grimes RM,Swint JM,Risser J

更新日期：2006-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Both metformin and acarbose are recommended monotherapy and add-on therapy in type 2 diabetes mellitus (T2DM). A fixed-dose combination (FDC) of acarbose and metformin has been developed to reduce pill burden and potentially improve compliance. The current study investigated the bioequivalen...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim S,Jang IJ,Shin D,Shin DS,Yoon S,Lim KS,Yu KS,Li J,Zhang H,Liu Y,Brendel E,Blode H,Wang Y

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scheele J,Diergarten K,Drevs J,Niazi FR

更新日期：2013-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mohee K,Wheatcroft SB

更新日期：2014-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The blood concentration of tacrolimus can be affected by co-administrated drugs. The objective is to draw more attention to herb-drug interactions in China, where herbal medicines are commonly used. CASE DESCRIPTION:The blood concentration of tacrolimus in a girl with refractory nephrotic s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yang P,He F,Tan M,Zhong F,Liao X,Li Y,Deng H,Mo X

更新日期：2021-02-01 00:00:00

abstract：:Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffe...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Calatayud O,Rodríguez M,Sánchez-Alcaraz A,Ibáñez P

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： do Prado-Lima P,Knijnik L,Juruena M,Padilla A

更新日期：2001-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lu PH,Tseng JC,Chen CK,Chen CH

更新日期：2017-08-01 00:00:00

abstract：:Blood ribavirin concentration was monitored after the administration of high-dose oral ribavirin in a case of adenovirus-induced haemorrhagic cystitis post-stem-cell transplantation. Combination use of intravenous gamma immunoglobulin (15 g/3 days) and high-dose ribavirin (RBV; 9000 mg/4 days) provided plasma ribaviri...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Homma M,Inoue Y,Hasegawa Y,Kojima H,Kohda Y

更新日期：2008-02-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00

abstract：:Recent reports of interactions between alcohol and benzodiazepines, tricyclic and tetracyclic antidepressants during their acute concomitant use are reviewed. Acute ingestion of alcohol (ethanol) with tranquilizers or hypnotics is responsible for several pharmacokinetic interactions that can have significant clinical ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tanaka E,Misawa S

更新日期：1998-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang T,Cheng H,Li Y,Dong YZ,Zhang Y,Cheng XL,Wang AM,Dong YL

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To report three cases of alopecia induced by the anticoagulant enoxaparin in cerebral venous thrombosis (CVT) patients. CASE SUMMARY:Three female patients were treated initially with direct intrasinus urokinase, and then followed by low-molecular-weight heparin (LMWH) enoxaparin at 1 mg/kg given subcutaneous...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang YY,Po HL

更新日期：2006-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Linezolid, a member of the oxazolidinone class of antibacterial drugs, is approved by the US Food and Drug Administration (FDA) for the treatment of vancomycin-resistant Enterococcus faecium infections, nosocomial and community-acquired pneumonia, as a part of anti tubercular regimen and com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Singhania SVK,Shenoy S,Kapoor D

更新日期：2020-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increa...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Francesca Notarangelo M,Marziliano N,Antonietta Demola M,Pigazzani F,Guidorossi A,Angelica Merlini P,Ardissino D

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P-glycoprotein (P-gp), after single-dose i.v. infusion in healthy Chinese volunteers. METHODS:We conducted a randomized, dose-escalating, phase I clinical study for that purpose. Thirty healthy subjects rec...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zheng L,Qing YP,Xu N,Yu Q,Wang Y,Wang FP,Li ZY

更新日期：2010-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study developed a population pharmacokinetic (PK) model of levetiracetam (LEV) for treating neonatal seizures (NS) and determined the influence of clinically relevant covariates to explain the interindividual variability and residual error. METHODS:Twenty newborns admitted to the Neona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lima-Rogel V,López-López EJ,Medellín-Garibay SE,Gómez-Ruiz LM,Romero-Méndez C,Milán-Segovia RC,Romano-Moreno S

更新日期：2018-06-01 00:00:00

abstract：:Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally acce...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Palikhe NS,Kim SH,Park HS

更新日期：2008-10-01 00:00:00

abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jacobson GA,Peterson GM,McLean S

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anton C,Cox AR,Watson RD,Ferner RE

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of 500 mg ornidazole vaginal ovules (VO) and vaginal tablets (VT) in the treatment of bacterial vaginosis. METHOD:Patients were allocated at random to one group of 50 subjects to be treated with a VO (500 mg) prepared in our laboratory and to a second group of 50 subjects to be treate...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Baloğlu E,Ozyazici M,Baloğlu A,Ova L

更新日期：2003-04-01 00:00:00

abstract：:Graft patency is a major factor contributing to the long-term results of coronary artery bypass graft (CABG) surgery. The systematic overview of the Antiplatelet Trialists' Collaboration provides unequivocal evidence that antiplatelet therapy reduces by nearly one-half the odds of coronary graft occlusion following CA...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galea J,Manché A,Goiti JJ,Locke TJ,Wilkinson GA,Smith GH

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF). AIM:To evaluate the effects of a macrolide antibio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yalçin E,Kiper N,Ozçelik U,Doğru D,Firat P,Sahin A,Ariyürek M,Mocan G,Gürcan N,Göçmen A

更新日期：2006-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Niacin commonly causes cutaneous flushing, which is partially alleviated by laropiprant, a selective antagonist of prostaglandin D2 at the DP1 receptor. Here we report an unusually high incidence of exanthematous eruption associated with the use of the extended-release (ER) niacin/laropipran...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yang YL,Hu M,Chang M,Tomlinson B

更新日期：2013-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable. CASE DESCRIPTION:A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ando M,Nakasako S,Ariyoshi K,Yamaguchi M,Sakizono K,Minowa K,Fukushima S,Sugioka N,Hashida T

更新日期：2019-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Little is known about the ability of community pharmacists who are inexperienced in medication review to identify drug-related problems (DRPs). The objective of our study was to investigate the completeness of DRPs in terms of number, type and clinical relevance identified by community phar...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kwint HF,Faber A,Gussekloo J,Bouvy ML

更新日期：2014-06-01 00:00:00