Steroids in multiple sclerosis.

abstract：WHAT IS KNOWN AND OBJECTIVE:Appraisal of drug information centres (DICs) is mainly by word of mouth communication and surveys of overall user satisfaction. Efforts to study the impact of this type of informatics and decision support systematically are generally lacking within the healthcare system. COMMENT:Scandinavia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Schjøtt J,Spigset O

更新日期：2019-06-01 00:00:00

abstract：:Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonly used antiepileptics...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tanaka E

更新日期：1999-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's synd...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tolomeo M,Colomba C,Meli M,Cascio A

更新日期：2019-12-01 00:00:00

abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Maiorini AF,Gaunt MJ,Jacobsen TM,McKay AE,Waldman LD,Raffa RB

更新日期：2002-06-01 00:00:00

abstract：:Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally acce...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Palikhe NS,Kim SH,Park HS

更新日期：2008-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lowering haemoglobin A(₁c) (HbA(₁c)) has clearly been shown to reduce microvascular complications of diabetes and possibly macrovascular disease and vitamin E has been suggested as a possibly useful intervention. Our aim is to evaluate the effect of vitamin E supplementation on glycaemic con...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suksomboon N,Poolsup N,Sinprasert S

更新日期：2011-02-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00

abstract：:A study was conducted in two groups of healthy volunteers to assess whether the time of administration (10 min before the meal versus 60 min after the meal) influences the pharmacokinetics and absorption kinetics of a slow-release theophylline product (Teonova). In the first group (Group A, n = 10), the drug was given...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Boner AL,Sette L,Messori A,Plebani M,Vallone G,Martini N

更新日期：1988-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Antituberculosis drug-induced liver injury (ATLI) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Rifampin (RIF) has been reported to cause haemolysis due to the production of drug-dependent antibodies, and haemolysis results in an increased level o...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tao B,Yang M,Chen H,Pan H,Liu W,Yi H,Tang S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Every prescriber knows that patients often do not take their medicines as prescribed. Hippocrates, the wise man of Kos, knew over two millennia ago. Our objective is to comment on the types of studies aimed at understanding and optimizing drug usage and to draw attention to the need to seek ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Li-Wan-Po A,Peterson GM

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Vancomycin is often used in antibiotic infusions for hospitalized patients and it is advantageous to prepare such intravenous solutions in advance. The objective of this study was to investigate the long-term stability of this antibiotic stored at 4 degrees C in polyvinyl chloride (PVC) bags. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galanti LM,Hecq JD,Vanbeckbergen D,Jamart J

更新日期：1997-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Antibiotic resistance has become a global public health issue. Most antibiotics are prescribed in the community, although there is less stewardship of such agents in the community compared to secondary and tertiary care. Few studies have attempted to examine the prescribing practices in Gene...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Goldsmith CE,Hara Y,Sato T,Nakajima T,Nakanishi S,Mason C,Moore JE,Matsuda M,Coulter WA

更新日期：2015-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex tre...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Laville F,Montana M,Roux N,Rathelot P,Giorgi R,Vanelle P

更新日期：2018-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. CASE DESCRIPTION:We present two cases of Lemierr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Le C,Gennaro D,Marshall D,Alaev O,Bryan A,Gelfman A,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:Graft patency is a major factor contributing to the long-term results of coronary artery bypass graft (CABG) surgery. The systematic overview of the Antiplatelet Trialists' Collaboration provides unequivocal evidence that antiplatelet therapy reduces by nearly one-half the odds of coronary graft occlusion following CA...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galea J,Manché A,Goiti JJ,Locke TJ,Wilkinson GA,Smith GH

更新日期：1994-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. Secondary forms of the disease may be due to consumption of trimethylamine precursor-rich foods or metabolism of some xenobiotics. CASE SUMMARY:A HI...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scimone C,Alibrandi S,Donato L,Giofrè SV,Rao G,Sidoti A,D'Angelo R

更新日期：2020-11-28 00:00:00

abstract：OBJECTIVE:To report the usefulness of antipsychotic dose-reduction for avoiding paralytic ileus in a patient with chronic schizophrenia and comorbid dementia. CASE SUMMARY:A 65-year-old in-patient developed severe paralytic ileus warranting a transfer to the general hospital. Constipation was very troublesome and he o...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suzuki T,Uchida H,Watanabe K,Kashima H

更新日期：2007-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feehan M,Walsh M,Godin J,Sundwall D,Munger MA

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Thomas J,Christenson JK,Walker E,Baby KE,Peterson GM

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Martin CS,Blaga C,Lambrescu IM,Fierbințeanu-Braticevici C,Fica S

更新日期：2015-10-01 00:00:00

abstract：:When assessing a health-care intervention the main question is--does it work? Often, a more difficult question needs to be answered--how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking,...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wiffen PJ,Moore RA

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2.50 and 5.00 mg/ ml) over a 30-day period. METHOD:Hig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oustric-Mendes AC,Huart B,Le Hoang MD,Perrin-Rosset M,Pailler FM,Darbord JC,Prognon P,Gard C,Pradeau D

更新日期：1997-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:5-Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS). CASE DESCRIPTION:We herein report an 83-year-old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hagino T,Shinomiya W,Hidai H,Umeda M,Kurimoto M,Saga R,Tsutsumi H,Shibata Y,Akiyama H,Motomura S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Many refractory/relapsed haematological malignancies, in non-remission state, still have poor prognosis even after allogeneic haematopoietic stem cell transplantation. Recently, decitabine or umbilical cord blood transplantation (UCBT) seemed to be effective in these patients. However, few s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yao W,Chu X,Fang X,Zhu X,Tang B,Wan X,Geng L,Tong J,Song K,Zhang X,Qiang P,Sun G,Liu H,Sun Z

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Morphine is one of the most widely used opioid analgesics for controlling pain in cancer and post-operative patients. OBJECTIVE:This study aimed at finding a sensitive method for measuring morphine. METHOD:A one-step solid phase extraction was developed for extracting morphine from various samples, and mor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mashayekhi SO,Ghandforoush-Sattari M,Hain RD

更新日期：2008-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Computerized physician order entry (CPOE) systems reduce medical errors (MEs). Nevertheless, a CPOE system may also lead to new types of errors, especially when it is first implemented. The objectives of this study were to determine the impact of a CPOE on the number of MEs and to identify t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sanchez Cuervo M,Rojo Sanchis A,Pueyo Lopez C,Gomez de Salazar Lopez de Silanes E,Gramage Caro T,Bermejo Vicedo T

更新日期：2015-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable. CASE DESCRIPTION:A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ando M,Nakasako S,Ariyoshi K,Yamaguchi M,Sakizono K,Minowa K,Fukushima S,Sugioka N,Hashida T

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：:To dose the anticonvulsant phenytoin (PHT) in a clinical situation is difficult because of the non-linear metabolism of the drug. Therefore many techniques have been advocated to aid dosage adjustments based on a single-point PHT concentration determined at steady-state (ss). We retrospectively investigated six method...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Ohtsubo K,Aoyama T

更新日期：1988-08-01 00:00:00