Effect of food on the bioavailability of a slow-release theophylline formulation.

abstract：:Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patien...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sangrador G,Sánchez-Alcaraz A,Ubeda R,Ibañez P

更新日期：1990-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin has been used for the management of post-herpetic neuralgia (PHN). However, inconsistent results have been reported. This meta-analysis was performed to assess the efficacy and safety of gabapentin 1800 mg/day in PHN patients by conducting a meta-analysis. METHODS:Electronic data...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fan H,Yu W,Zhang Q,Cao H,Li J,Wang J,Shao Y,Hu X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The penetration of generic drugs in the Greek pharmaceutical market is placed among the weakest in the EU. The Greek regulatory framework does not systematically support the development of this subsector and physicians are not provided with incentives for prescribing generics. The aim of this s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tsiantou V,Zavras D,Kousoulakou H,Geitona M,Kyriopoulos J

更新日期：2009-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Baking soda is a common household product promoted by the manufacturer as an antacid. It contains sodium bicarbonate and has the potential for significant toxicity when ingested in excessive amounts. Characterizing the patterns and outcomes from the misuse of baking soda as a home remedy can...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Al-Abri SA,Kearney T

更新日期：2014-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-ana...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suksomboon N,Poolsup N,Punthanitisarn S

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Renal function was estimated in 129 elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) who were treated with vancomycin (VCM). The estimation was performed by substituting serum creatinine (SCR) measured enzymatically and a value converted using the Jaffe method into the Cockcroft-Gault ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tsuji Y,Hiraki Y,Mizoguchi A,Sadoh S,Sonemoto E,Kamimura H,Karube Y

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： do Prado-Lima P,Knijnik L,Juruena M,Padilla A

更新日期：2001-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study developed a population pharmacokinetic (PK) model of levetiracetam (LEV) for treating neonatal seizures (NS) and determined the influence of clinically relevant covariates to explain the interindividual variability and residual error. METHODS:Twenty newborns admitted to the Neona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lima-Rogel V,López-López EJ,Medellín-Garibay SE,Gómez-Ruiz LM,Romero-Méndez C,Milán-Segovia RC,Romano-Moreno S

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gill PS,Roalfe A

更新日期：2001-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT:There are two classes of epi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Peedicayil J

更新日期：2012-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:With increased opioid use, drug-drug interactions (DDIs) and associated adverse events are growing among geriatric patients. However, the clinical significance of potential metabolic DDIs associated with opioid use has not been fully evaluated among geriatric patients. Particularly, cytochro...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim JH,Kim JY,Lee N,Yee J,Gwak HS

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Crane IM,Mulhern MG,Nema S

更新日期：2003-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:5-Azacitidine (AZA) is an agent widely used to treat myelodysplastic syndrome (MDS). CASE DESCRIPTION:We herein report an 83-year-old woman diagnosed with MDS who was treated with AZA. She tolerated the first cycle of AZA; however, severe adverse events involving haemorrhagic enteritis with...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hagino T,Shinomiya W,Hidai H,Umeda M,Kurimoto M,Saga R,Tsutsumi H,Shibata Y,Akiyama H,Motomura S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang D,Hao J,Hou R,Yu Y,Hu B,Wei L

更新日期：2020-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lowering haemoglobin A(₁c) (HbA(₁c)) has clearly been shown to reduce microvascular complications of diabetes and possibly macrovascular disease and vitamin E has been suggested as a possibly useful intervention. Our aim is to evaluate the effect of vitamin E supplementation on glycaemic con...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suksomboon N,Poolsup N,Sinprasert S

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:The use of psychotropic drugs has increased continuously over recent years in industrialized countries. In Europe, France has the highest consumption of such drugs. The aim of this study was to identify the sociodemographic and medical factors associated with the use of psychotropic agents. METHODS:Data, co...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Empereur F,Baumann M,Alla F,Briançon S

更新日期：2003-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Different population pharmacokinetics (PPK) models of tacrolimus have been established in various populations. However, the tacrolimus PPK model in paediatric systemic lupus erythematosus (PSLE) is still undefined. This study aimed to establish the tacrolimus PPK model in Chinese PSLE. MET...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang DD,Lu JM,Li Q,Li ZP

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data. METHOD:The steady-state blood level data (n = 129) after repetitive oral administration in 71 hospitalized neonates were analysed using Nonlinear Mixed Effects Modellin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Akiyama K,Suematsu F,Yukawa M,Minemoto M

更新日期：2007-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Two NS3/4A protease inhibitors (PIs), telaprevir and boceprevir, were recently approved in the United States. The primary objective was to compare the efficacy and safety of triple therapies including either PI to dual therapy in patients with chronic hepatitis C genotype 1; the secondary ob...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Park C,Jiang S,Lawson KA

更新日期：2014-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The HbA1C marker used in assessing diabetes control quality is not sufficient in diabetes patients with thalassaemia. CASE DESCRIPTION:A male diabetic patient with thalassaemia was hospitalized due to distal neuropathic pain, right toe trophic ulcer, unacceptable five-point glycaemic profil...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gluvic Z,Obradovic M,Lackovic M,Samardzic V,Tica Jevtic J,Essack M,Bajic VB,Isenovic ER

更新日期：2020-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Thomas J,Christenson JK,Walker E,Baby KE,Peterson GM

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Glucagon-like peptide-1 (GLP-1) receptor agonists delay gastric and bowel emptying. A similar inhibitory effect of GLP-1 on gallbladder motility has been suggested, possibly leading to an increased risk of cholecystitis related to incretin-based medications, which include GLP-1 antagonists. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pizzimenti V,Giandalia A,Cucinotta D,Russo GT,Smits M,Cutroneo PM,Trifirò G

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To highlight therapeutic controversies, and present a critical review of the most recent evidence on the management of heparin-induced thrombocytopenia (HIT). DATA SOURCES:A MEDLINE search from October 1996 until October 2006 was carried out. Pertinent literature was identified and other references identifi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hassan Y,Awaisu A,Aziz NA,Aziz NH,Ismail O

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Ticagrelor is a reversibly binding and selective P2Y12 -receptor antagonist approved for the prevention of atherothrombotic events in patients with acute coronary syndromes. As bleeding events remain a hazard with antiplatelet therapy, this study investigated the effect of the vasopressin ag...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Teng R,Mitchell PD,Butler K

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang T,Cheng H,Li Y,Dong YZ,Zhang Y,Cheng XL,Wang AM,Dong YL

更新日期：2019-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abodunde OA,LevakaVeera RR,Desai R,Nweke N,Berrou M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2.50 and 5.00 mg/ ml) over a 30-day period. METHOD:Hig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oustric-Mendes AC,Huart B,Le Hoang MD,Perrin-Rosset M,Pailler FM,Darbord JC,Prognon P,Gard C,Pradeau D

更新日期：1997-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Therapeutic effects of anti-VEGF agents, corticosteroids and laser therapy have been previously examined for treating macular oedema secondary to branch and central retinal vein occlusion (BRVO and CRVO). However, anti-VEGF efficacy has not been previously compared to corticosteroid or laser...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Qian T,Zhao M,Xu X

更新日期：2017-10-01 00:00:00

abstract：:This study examined out-patients' interpretation of prescription instructions at a community hospital. The results showed a wide range of misinterpretation with respect to drug name, dose schedule, and auxiliary labels. Age level, education and financial status emerged as the most significant variables associated with...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sarriff A,Aziz NA,Hassan Y,Ibrahim P,Darwis Y

更新日期：1992-04-01 00:00:00