Abstract：
OBJECTIVES:To highlight therapeutic controversies, and present a critical review of the most recent evidence on the management of heparin-induced thrombocytopenia (HIT). DATA SOURCES:A MEDLINE search from October 1996 until October 2006 was carried out. Pertinent literature was identified and other references identified from the bibliographic citations of the articles identified on MEDLINE. STUDY SELECTION:Articles related to the treatment of HIT including meta-analyses, systematic reviews, critical reviews, randomized and non-randomized trials, as well as case-reports, were reviewed. RESULTS AND CONCLUSION:The diagnostic and therapeutic dilemmas associated with HIT can be overwhelming and call for an evidence-based approach in the management of this frequently fatal event. HIT is associated with significant morbidity and mortality. The evidence suggests when heparin is stopped, alternative anticoagulant therapy with one of the newer agents such as lepirudin and argatroban is of benefit in avoiding deaths and morbidity.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Hassan Y,Awaisu A,Aziz NA,Aziz NH,Ismail Odoi
10.1111/j.1365-2710.2007.00865.xsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
535-44issue
6eissn
0269-4727issn
1365-2710pii
JCP865journal_volume
32pub_type
杂志文章,评审abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12123
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2002.00386.x
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:To assess the usefulness of dynamic laser scattering for monitoring the stability of ampicillin after reconstitution from commercially available vials with respect to the polymer formation and potency. METHODS:Polymer formation and the remaining potency of the reconstituted ampicillin solution were estimated...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2002.00397.x
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2001.00371.x
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:To probe the pharmacokinetic basis for the use of levofloxacin for complicated skin and skin-structure infections (SSSIs) at a once-daily dosage of 750 mg by investigating its penetration into skin tissue. METHOD:Ten healthy volunteers were administered three oral, once-daily 750 mg doses of levofloxacin, an...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2710.2002.00396.x
更新日期：2002-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13162
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:A pain relief score 50% of the maximum is often used as a clinically meaningful outcome in meta-analyses of analgesic trials. This arbitrary value requires validation. OBJECTIVE:To determine the optimum pain relief score for predicting pain relief sufficient to obviate the need for analgesic remedication in...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/j.1365-2710.2006.00719.x
更新日期：2006-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12312
更新日期：2015-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Every prescriber knows that patients often do not take their medicines as prescribed. Hippocrates, the wise man of Kos, knew over two millennia ago. Our objective is to comment on the types of studies aimed at understanding and optimizing drug usage and to draw attention to the need to seek ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 社论
doi：10.1111/jcpt.13325
更新日期：2021-02-01 00:00:00
abstract：:Recent reports of interactions between alcohol and benzodiazepines, tricyclic and tetracyclic antidepressants during their acute concomitant use are reviewed. Acute ingestion of alcohol (ethanol) with tranquilizers or hypnotics is responsible for several pharmacokinetic interactions that can have significant clinical ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.1998.00175.x
更新日期：1998-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Appraisal of drug information centres (DICs) is mainly by word of mouth communication and surveys of overall user satisfaction. Efforts to study the impact of this type of informatics and decision support systematically are generally lacking within the healthcare system. COMMENT:Scandinavia...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12804
更新日期：2019-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. Secondary forms of the disease may be due to consumption of trimethylamine precursor-rich foods or metabolism of some xenobiotics. CASE SUMMARY:A HI...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13315
更新日期：2020-11-28 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMME...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12691
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.0269-4727.2003.00503.x
更新日期：2003-10-01 00:00:00
abstract：:A stability-indicating reversed phase high-performance liquid chromatographic assay for prazosin was developed to investigate the feasibility of a transdermal dosage form. The assay enabled detection of drug concentrations down to 0.05 microgram/ml and the quantification of the drug in both permeation fluids and in ex...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1992.tb01262.x
更新日期：1992-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Chemotherapy can increase treatment-related mortality associated with future haematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukaemia (AML). There is usually insufficient time to find a suitable unrelated donor for these patients. We repor...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12251
更新日期：2015-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's synd...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13033
更新日期：2019-12-01 00:00:00
abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.2002.00415.x
更新日期：2002-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Computerized physician order entry (CPOE) systems reduce medical errors (MEs). Nevertheless, a CPOE system may also lead to new types of errors, especially when it is first implemented. The objectives of this study were to determine the impact of a CPOE on the number of MEs and to identify t...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12305
更新日期：2015-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The STOPP/START tool has been validated to assess elderly patients for potentially inappropriate prescribing. This study aimed to assess the effect of inclusion of a pharmacist on a physician-led ward round on potentially inappropriate prescribing in hospitalized elderly patients. METHODS:T...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12489
更新日期：2017-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12047
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Emerging antibiotic resistance in common pathogens is a worldwide problem known to be related to inappropriate overuse of antibiotics. Wide variability in antibiotic use throughout the world is because of various factors, including socio-cultural differences. OBJECTIVE:To study the rate of antibiotic prescr...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00960.x
更新日期：2008-12-01 00:00:00
abstract：:The aim of the study was to determine the usage patterns of benzodiazepine hypnotics, the use of other ways of improving sleep and general sleep characteristics in patients prescribed these drugs on a regular basis and in a control group of age- and sex-matched patients not receiving hypnotics. Patients receiving regu...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1995.tb00634.x
更新日期：1995-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Niacin commonly causes cutaneous flushing, which is partially alleviated by laropiprant, a selective antagonist of prostaglandin D2 at the DP1 receptor. Here we report an unusually high incidence of exanthematous eruption associated with the use of the extended-release (ER) niacin/laropipran...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12096
更新日期：2013-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. CASE SUMMARY:We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium afte...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13116
更新日期：2020-10-01 00:00:00
abstract：:The treatment of home-based cancer patients with continuous infusion chemotherapy requires that complete courses of medication in pre-filled syringes are provided on an out-patient basis. The infusion must remain stable prior to use during refrigerated storage (up to 14 days) and during infusion from holster-worn ambu...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1988.tb00185.x
更新日期：1988-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12631
更新日期：2017-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Metronidazole is one of the drugs with a well-recognized potential to rarely cause acute pancreatitis. The relation of other drugs of the 5-aminoimidazole group (e.g. tinidazole) to acute pancreatitis remains unknown. For the treatment of protozoal infections, tinidazole may be considered as...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12307
更新日期：2015-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Nephrotoxicity is a recognized side effect of cisplatin chemotherapy. However, the optimal strategy for preventing cisplatin-induced nephrotoxicity, if any, remains unclear. The primary objective for this study was to determine whether mannitol or furosemide provides better nephroprotection ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12509
更新日期：2017-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality, and frequent exacerbations are associated with an increased risk of death, deterioration in lung function and reduced quality of life. Current Australian guidelines developed by the Lung Foun...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12514
更新日期：2017-06-01 00:00:00
