Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report.

Abstract:

WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, treated with oral budesonide, was admitted for Cushingoid symptoms and signs. The onset coincided with the use of fluvoxamine, a serotonin reuptake inhibitor and also a potent inhibitor of cytochrome P450 enzymes that presumably led to budesonide accumulation. WHAT IS NEW AND CONCLUSION:Practitioners should take into consideration the possibility of iatrogenic Cushing's syndrome caused by the association of oral budesonide with a P450 cytochrome inhibitor.

journal_name

J Clin Pharm Ther

authors

Martin CS,Blaga C,Lambrescu IM,Fierbințeanu-Braticevici C,Fica S

doi

10.1111/jcpt.12312

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

612-614

issue

5

eissn

0269-4727

issn

1365-2710

journal_volume

40

pub_type

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