Penetration of levofloxacin into skin tissue after oral administration of multiple 750 mg once-daily doses.

Abstract:

OBJECTIVE:To probe the pharmacokinetic basis for the use of levofloxacin for complicated skin and skin-structure infections (SSSIs) at a once-daily dosage of 750 mg by investigating its penetration into skin tissue. METHOD:Ten healthy volunteers were administered three oral, once-daily 750 mg doses of levofloxacin, and levofloxacin concentrations were subsequently measured over time (0.5-24 h) in skin-punch biopsy tissue and plasma. RESULTS:Skin tissue concentrations consistently exceeded those in plasma at every time point, with tissue/plasma ratios of 1.37 +/- 0.81 for peak concentration and 1.97 +/- 0.35 for area under the concentration versus time curve. Three of the ten subjects reported treatment-emergent adverse events (AEs) that were considered unrelated to treatment. An 11th subject who had enrolled in the study withdrew after AEs of mild severity that were possibly related to the study drug. CONCLUSION:The results support the clinical usage of levofloxacin 750 mg once-daily for complicated SSSIs.

journal_name

J Clin Pharm Ther

authors

Chow AT,Chen A,Lattime H,Morgan N,Wong F,Fowler C,Williams RR

doi

10.1046/j.1365-2710.2002.00396.x

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

143-50

issue

2

eissn

0269-4727

issn

1365-2710

pii

396

journal_volume

27

pub_type

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