Does levodopa improve swallowing dysfunction in Parkinson's disease patients?

Abstract:

OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +/- standard deviation were considered for analysis. The primary efficacy variables were Oral Transit Time (OTT), Pharyngeal Transit Time (PTT) for both thin fluids and solids, and aspiration. RESULTS:Seven studies describing swallowing functions in PD patients using levodopa were found, and five of these matched the inclusion criteria. No clinically meaningful improvement after levodopa intake was noted. Adverse effects were not reported by the authors. CONCLUSION:This meta-analysis shows that levodopa intake was not associated with an improvement of swallowing dysfunction in Parkinson's disease patients.

journal_name

J Clin Pharm Ther

authors

Menezes C,Melo A

doi

10.1111/j.1365-2710.2009.01031.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

673-6

issue

6

eissn

0269-4727

issn

1365-2710

pii

JCP1031

journal_volume

34

pub_type

杂志文章,meta分析
  • Treatment of irritable bowel syndrome.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The complexity and diversity of irritable bowel syndrome's (IBS) presentation make treatment difficult. Although there are reviews and guidelines for treating IBS, they focus on the efficacy of medications for IBS symptoms using high-priority endpoints, leaving those of lower priority largel...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2710.2010.01177.x

    authors: Trinkley KE,Nahata MC

    更新日期:2011-06-01 00:00:00

  • Humanistic and economic outcomes of pharmacist-provided medication review in the community-dwelling elderly: A systematic review and meta-analysis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Recent reviews have shown that pharmacist-provided medication review in the elderly can improve clinical outcomes and reduce medication discrepancies compared with usual care. However, none determined whether these translate to improved humanistic and economic outcomes. This review sought to...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jcpt.12453

    authors: Loh ZW,Cheen MH,Wee HL

    更新日期:2016-12-01 00:00:00

  • Association of ABO blood group and antituberculosis drug-induced liver injury: A case-control study from a Chinese Han population.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Antituberculosis drug-induced liver injury (ATLI) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Rifampin (RIF) has been reported to cause haemolysis due to the production of drug-dependent antibodies, and haemolysis results in an increased level o...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.13139

    authors: Tao B,Yang M,Chen H,Pan H,Liu W,Yi H,Tang S

    更新日期:2020-08-01 00:00:00

  • Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.2010.01163.x

    authors: Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S

    更新日期:2011-04-01 00:00:00

  • Drug-induced parotitis.

    abstract::Drug-induced parotitis is a relatively uncommon adverse drug reaction. Most of the data on drug-induced parotitis consist of isolated case reports with few attempts at rechallenge to confirm the aetiology. Phenylbutazone and oxyphenbutazone have a significant number of reports suggesting that these drugs may be implic...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2710.1993.tb00584.x

    authors: Thompson DF

    更新日期:1993-08-01 00:00:00

  • Drug utilization pattern of antiepileptic drugs and traditional Chinese medicines in a general hospital in Taiwan - a pharmaco-epidemiologic study.

    abstract:OBJECTIVE:Studies on antiepileptic drug utilization are important for the optimization of drug therapy and drug control. The present study was to evaluate the drug utilization pattern of standard antiepileptic drugs and traditional Chinese medicines (TCMs) in the treatment of different types of epilepsy in a general ho...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2710.2000.00271.x

    authors: Chen LC,Chen YF,Yang LL,Chou MH,Lin MF

    更新日期:2000-04-01 00:00:00

  • Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences.

    abstract:OBJECTIVE:To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. METHOD:Eleven healthy individuals (26-61 years of age) were evaluated at basel...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2710.2005.00658.x

    authors: Agnew LL,Guffogg SP,Matthias A,Lehmann RP,Bone KM,Watson K

    更新日期:2005-08-01 00:00:00

  • Effects of vitamin E supplementation on glycaemic control in type 2 diabetes: systematic review of randomized controlled trials.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Lowering haemoglobin A(₁c) (HbA(₁c)) has clearly been shown to reduce microvascular complications of diabetes and possibly macrovascular disease and vitamin E has been suggested as a possibly useful intervention. Our aim is to evaluate the effect of vitamin E supplementation on glycaemic con...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1365-2710.2009.01154.x

    authors: Suksomboon N,Poolsup N,Sinprasert S

    更新日期:2011-02-01 00:00:00

  • In vitro dissolution studies on nifedipine capsules.

    abstract::The in vitro dissolution rates of 5 and 10 mg nifedipine capsules from eight suppliers were measured in simulated gastric fluid using the rotating paddle apparatus. A total of fourteen products were tested and the performance was found to be satisfactory for all products (> 80% dissolution in 20 min). ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.1995.tb00656.x

    authors: Mehta AC,Hart-Davies S,Kay EA

    更新日期:1995-08-01 00:00:00

  • Generic medicines: Greek physicians' perceptions and prescribing practices.

    abstract:BACKGROUND AND OBJECTIVE:The penetration of generic drugs in the Greek pharmaceutical market is placed among the weakest in the EU. The Greek regulatory framework does not systematically support the development of this subsector and physicians are not provided with incentives for prescribing generics. The aim of this s...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.2009.01037.x

    authors: Tsiantou V,Zavras D,Kousoulakou H,Geitona M,Kyriopoulos J

    更新日期:2009-10-01 00:00:00

  • Decreased INR after acenocoumarol, ombitasvir/paritaprevir/ritonavir and dasabuvir co-administration.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type:

    doi:10.1111/jcpt.12403

    authors: de Lorenzo-Pinto A,Giménez-Manzorro Á,Rodríguez-González CG,Ahumada-Jiménez A,Herranz-Alonso A,Marzal-Alfaro MB,Sanjurjo-Sáez M

    更新日期:2016-08-01 00:00:00

  • Prescribing pattern in a Dutch university hospital.

    abstract::In many countries, including The Netherlands, little is known about the overall prescribing patterns within hospitals. While individual hospitals have some data available, these are not pooled on a regional or national level. The available data consist of dispensing data that are neither patient-linked nor diagnosis-l...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.1991.tb00332.x

    authors: Denig P,Haaijer-Ruskamp FM,Versluis A,Wesseling H

    更新日期:1991-12-01 00:00:00

  • Factors associated with the consumption of psychotropic drugs in a cohort of men and women aged 50 and over.

    abstract:OBJECTIVES:The use of psychotropic drugs has increased continuously over recent years in industrialized countries. In Europe, France has the highest consumption of such drugs. The aim of this study was to identify the sociodemographic and medical factors associated with the use of psychotropic agents. METHODS:Data, co...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2710.2003.00464.x

    authors: Empereur F,Baumann M,Alla F,Briançon S

    更新日期:2003-02-01 00:00:00

  • Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Fluconazole is an antifungal agent that is commonly used to treat patients with serious systemic fungal infections in intensive care units. Fosfluconazole is a phosphate prodrug of fluconazole, which was developed to reduce the volume of fluid required to administer fluconazole by intravenou...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.2011.01297.x

    authors: Aoyama T,Hirata K,Hirata R,Yamazaki H,Yamamoto Y,Hayashi H,Matsumoto Y

    更新日期:2012-06-01 00:00:00

  • Stability and compatibility of anakinra with ceftriaxone sodium injection in 0.9% sodium chloride or 5% dextrose injection.

    abstract::The stability and compatibility of anakinra (recombinant human interleukin-1 receptor antagonist) with ceftriaxone sodium in 0.9% sodium chloride or 5% dextrose injection was determined during a 4-h period at ambient room temperature and light. Anakinra was diluted in 0.9% sodium chloride or 5% dextrose to the concent...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2710.1997.95275952.x

    authors: Nahata MC,Morosco RS,Sabados BK,Weber TR

    更新日期:1997-06-01 00:00:00

  • Particulate contamination of lyophilized amphotericin B preparation during reconstitution process.

    abstract:OBJECTIVE:To investigate the effect of the reconstitution methods for the commercial amphotericin B preparation with respect to particulate contamination. METHODS:The particle counts in amphotericin B solutions reconstituted according to three different methods and amphotericin B fluids made with intravenous fluids af...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2710.2001.00328.x

    authors: Sendo T,Hirakawa M,Makino K,Nakashima K,Kataoka Y,Oishi R

    更新日期:2001-04-01 00:00:00

  • Use of Tris-hydroxymethyl aminomethane in severe lactic acidosis due to highly active antiretroviral therapy: a case report.

    abstract:BACKGROUND:Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HI...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.2008.00977.x

    authors: Marfo K,Garala M,Kvetan V,Gasperino J

    更新日期:2009-02-01 00:00:00

  • Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand.

    abstract:BACKGROUND:Drug-drug interaction is a potential cause of adverse drug reactions. The incidence of such drug interactions in university hospitals in Thailand is unknown. PURPOSE:To estimate the rate of potential drug-drug interactions in outpatients of a typical Thai university hospital, and to identify risk factors fo...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.2004.00598.x

    authors: Janchawee B,Wongpoowarak W,Owatranporn T,Chongsuvivatwong V

    更新日期:2005-02-01 00:00:00

  • Impact of pharmacist intervention on antibiotic use and prophylactic antibiotic use in urology clean operations.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The use of prophylactic antibiotics in clean operations was routine in China before 2011. Along with the appeal for using antibiotics rationally by WHO in 2011, China launched a national special rectification scheme on clinical use of antibiotics from April that year. The scheme, aimed at ac...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.12275

    authors: Zhou Y,Ma LY,Zhao X,Tian SH,Sun LY,Cui YM

    更新日期:2015-08-01 00:00:00

  • Serum creatinine levels during cardiac surgery: absence of effect by aminoglycosides.

    abstract::The literature indicates that the relative nephrotoxicities of the three drugs used in this investigation are gentamicin > tobramycin > or = netilmicin. Serum creatinine levels over time were used in an attempt to elucidate the situation. They varied widely in all three groups and in controls in theatre. No definite t...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2710.1993.tb00607.x

    authors: Bertram D,Summers R

    更新日期:1993-06-01 00:00:00

  • CYP2D6 phenotypes among Malays in Malaysia.

    abstract:BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2710.2000.00304.x

    authors: Ismail R,Hussein A,Teh LK,Nizam Isa M

    更新日期:2000-10-01 00:00:00

  • Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study.

    abstract:WHAT IS KNOWN AND OBJECTIVE:There are no clinical reports that have compared topiroxostat, a selective xanthine oxidase inhibitor, with allopurinol in serum urate-lowering efficacy. The aim of this study was to compare the efficacy and safety of topiroxostat and allopurinol in Japanese hyperuricemic patients with or wi...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/jcpt.12391

    authors: Hosoya T,Ogawa Y,Hashimoto H,Ohashi T,Sakamoto R

    更新日期:2016-06-01 00:00:00

  • Decitabine prior to salvaged cord blood transplantation for acute myeloid leukaemia/myelodysplastic syndrome not in remission.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Many refractory/relapsed haematological malignancies, in non-remission state, still have poor prognosis even after allogeneic haematopoietic stem cell transplantation. Recently, decitabine or umbilical cord blood transplantation (UCBT) seemed to be effective in these patients. However, few s...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.13231

    authors: Yao W,Chu X,Fang X,Zhu X,Tang B,Wan X,Geng L,Tong J,Song K,Zhang X,Qiang P,Sun G,Liu H,Sun Z

    更新日期:2020-12-01 00:00:00

  • Comparative analysis of the efficacy of angiotensin II receptor blockers for uric acid level change in asymptomatic hyperuricaemia.

    abstract:WHAT IS KNOWN AND OBJECTIVE:There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.13202

    authors: Kim HS,Kim H,Lee SH,Kim JH

    更新日期:2020-12-01 00:00:00

  • Retinoic acid syndrome: a review.

    abstract::The retinoic acid syndrome (RAS) is an unpredictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most commonly in patients with acute promyelocytic leukaemia (APL). In this review, we describe the incidence, predictive factors, clinical course, outcome and treatme...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2710.2008.00935.x

    authors: Patatanian E,Thompson DF

    更新日期:2008-08-01 00:00:00

  • Spontaneous bilateral haemothorax with haemopericardium secondary to rivaroxaban.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. CASE SUMMARY:We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium afte...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type:

    doi:10.1111/jcpt.13116

    authors: Yu JH,Liu HH,Hsieh MJ,Hsieh IC,Chu PH,Chen DY

    更新日期:2020-10-01 00:00:00

  • A Computer Prescribing Order Entry-Clinical Decision Support system designed for neonatal care: results of the 'preselected prescription' concept at the bedside.

    abstract:WHAT IS KNOWN:The neonatal intensive care units (NICUs) are at the highest risk of drug dose error of all hospital wards. NICUs also have the most complicated prescription modalities. The computerization of the prescription process is currently recommended to decrease the risk of preventable adverse drug effects (pADEs...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.12474

    authors: Gouyon B,Iacobelli S,Saliba E,Quantin C,Pignolet A,Jacqz-Aigrain E,Gouyon JB

    更新日期:2017-02-01 00:00:00

  • Serum vitamin E level in patients with breast cancer.

    abstract::In this study, the serum vitamin E (total tocopherol) levels in patients with breast cancer (n = 100) and healthy controls (n = 70) were measured. The mean values for vitamin E were found to be 0.44 mg/100 ml in breast cancer patients and 1.108 mg/100 ml in controls. In the statistical evaluation, the vitamin E levels...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2710.1995.tb00645.x

    authors: Torun M,Akgül S,Sargin H

    更新日期:1995-06-01 00:00:00

  • Comparison of sedation with dexmedetomidine vs propofol during hysteroscopic surgery: Single-centre randomized controlled trial.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The most appropriate sedative agent for conscious sedation in minor hysteroscopic surgeries is still unclear. Dexmedetomidine a sedative and analgesic agent, may be appropriate for outpatient procedures. The aim of our study was to compare the sedative, analgesic and hemodynamic effects of d...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jcpt.12793

    authors: Bingol Tanriverdi T,Koceroglu I,Devrim S,Gura Celik M

    更新日期:2019-04-01 00:00:00

  • Scabies-An ancient itch that is still rampant today.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章

    doi:10.1111/jcpt.12631

    authors: Thomas J,Christenson JK,Walker E,Baby KE,Peterson GM

    更新日期:2017-12-01 00:00:00