Abstract：
:The objectives of this study were: (a) to develop a drug serum level-based compliance measure which incorporated pharmacokinetic analysis of patient and drug parameters and to compare it to refill records, an indirect measure, and (b) to use that measure to determine whether pharmacist consultation increased compliance. Sixty adult, male chronic obstructive pulmonary disease out-patients who received theophylline were randomly assigned to one of two groups with counselling provided to experimental-group patients only. Compliance was measured by the ratio of actual serum theophylline level to that predicted by pharmacokinetic estimation and by the number of refills in 155 days. More experimental-group patients had actual levels within both +/- 10% and +/- 20% of predicted levels (P = 0.0006 and 0.04). They also obtained more refills than control patients (P = 0.05). The pharmacokinetically based serum level measure appeared to be the more useful measure for identifying non-compliance, which suggests that it is of greater value than existing measures. In addition, the results suggest that comprehensive consultation by a clinical pharmacists can improve compliance with theophylline therapy in the out-patient setting.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
De Tullio PL,Kirking DM,Arslanian C,Olson DEsubject
Has Abstractpub_date
1987-02-01 00:00:00pages
19-26issue
1eissn
0269-4727issn
1365-2710journal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract：WHAT IS KNOWN AND OBJECTIVES:Little is known about the ability of community pharmacists who are inexperienced in medication review to identify drug-related problems (DRPs). The objective of our study was to investigate the completeness of DRPs in terms of number, type and clinical relevance identified by community phar...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12132
更新日期：2014-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Inhaled treprostinil represents an attractive alternative to the other available prostacyclin formulations by obviating the use of continuous infusions and its associated risks. Published evidence describing the process of transition from infusion prostacyclin therapy to inhaled treprostinil...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12170
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Although the kinetic behaviour of tramadol has been described, the present study is the first to our knowledge, to report specifically on the population pharmacokinetic modelling of tramadol hydrochloride. METHODS:The parametric Iterative Two-stage Bayesian Population Model (IT2B) program foll...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2710.2004.00590.x
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2000.00310.x
更新日期：2000-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13162
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Patients with congestive heart failure (CHF) are at risk for hyperkalemia because of coexisting comorbidities and use of multiple medications that impair potassium (K) excretion such as angiotensin converting enzyme (ACE) inhibitors. OBJECTIVE:To identify clinical factors associated with hyperkalemia on ini...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2005.00638.x
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment of infants and children, as well as elderly people, who are more sensitive to dosage errors. Previous studies revealed significant dosage inaccuracies with measuring...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2009.01082.x
更新日期：2010-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13201
更新日期：2020-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12574
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00910.x
更新日期：2008-06-01 00:00:00
abstract：:The treatment of home-based cancer patients with continuous infusion chemotherapy requires that complete courses of medication in pre-filled syringes are provided on an out-patient basis. The infusion must remain stable prior to use during refrigerated storage (up to 14 days) and during infusion from holster-worn ambu...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1988.tb00185.x
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:To describe the current practice of Israeli paediatricians regarding acetaminophen dosing. METHODS:A cross-sectional survey among 200 paediatricians. The paediatricians were questioned of the recommended dose of acetaminophen, and whether they give prescriptions for acetaminophen and instruct their patients ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2005.00661.x
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Moxifloxacin is a new fluorquinolone with broad-spectrum activity. It is suitable for treating peritonitis in peritoneal dialysis (PD) patients. The objective of this study was to test stability of moxifloxacin in PD solutions stored at different temperatures. METHODS:Dialysis solution bags we...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2006.00758.x
更新日期：2006-12-01 00:00:00
abstract：:The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickins...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1995.tb00705.x
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVE:To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data. METHOD:The steady-state blood level data (n = 129) after repetitive oral administration in 71 hospitalized neonates were analysed using Nonlinear Mixed Effects Modellin...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2007.00833.x
更新日期：2007-08-01 00:00:00
abstract：:Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffe...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2710.1995.tb00621.x
更新日期：1995-02-01 00:00:00
abstract：:The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.2000.00260.x
更新日期：2000-02-01 00:00:00
abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.2002.00415.x
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To determine whether any demographic or socioeconomic factors affect the use of smoking cessation medications in patients hospitalized with heart disease. METHOD:Data were obtained from the Improving Cardiovascular Outcomes in Nova Scotia (ICONS) Canada database, which includes a registry of all hospitalized...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2004.00622.x
更新日期：2005-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The current pharmacotherapeutic treatment of major depressive disorder (MDD) generally takes weeks to be effective. As the molecular action of these drugs is immediate, the mechanistic basis for this lag is unclear. A drug that has a more rapid onset of action would be a major therapeutic ad...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12238
更新日期：2015-04-01 00:00:00
abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1997.tb00005.x
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy. METHOD:Serum samples examined in the study were obtained from 41 paediatric patients (23 male, 18 female) with epilepsy on phenytoin monotherapy. Their age ranged from 1 to...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2001.00340.x
更新日期：2001-06-01 00:00:00
abstract：WHAT IS KNOWN:The neonatal intensive care units (NICUs) are at the highest risk of drug dose error of all hospital wards. NICUs also have the most complicated prescription modalities. The computerization of the prescription process is currently recommended to decrease the risk of preventable adverse drug effects (pADEs...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12474
更新日期：2017-02-01 00:00:00
abstract：:A study was conducted in two groups of healthy volunteers to assess whether the time of administration (10 min before the meal versus 60 min after the meal) influences the pharmacokinetics and absorption kinetics of a slow-release theophylline product (Teonova). In the first group (Group A, n = 10), the drug was given...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2710.1988.tb00509.x
更新日期：1988-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Both metformin and acarbose are recommended monotherapy and add-on therapy in type 2 diabetes mellitus (T2DM). A fixed-dose combination (FDC) of acarbose and metformin has been developed to reduce pill burden and potentially improve compliance. The current study investigated the bioequivalen...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12166
更新日期：2014-08-01 00:00:00
abstract：:Drug infusions can be exposed for prolonged periods to 'in-use' conditions where the temperature of an infusion in a holster-worn infusion pump may reach 37 degrees C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5-fluorouracil and mitozantrone) and one analgesic infusion (diamorphine H...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1991.tb00293.x
更新日期：1991-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT:There are two classes of epi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2012.01346.x
更新日期：2012-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Lactic acidosis (LA) is a rare but potentially lethal side effect of linezolid (LZD). However, limited by the study population, the number of patients with LA is insufficient to summarize all the clinical characteristics and risk factors. METHODS:We evaluated the association between LZD and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13245
更新日期：2020-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13097
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:Studies on antiepileptic drug utilization are important for the optimization of drug therapy and drug control. The present study was to evaluate the drug utilization pattern of standard antiepileptic drugs and traditional Chinese medicines (TCMs) in the treatment of different types of epilepsy in a general ho...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2000.00271.x
更新日期：2000-04-01 00:00:00
