How much acetaminophen do paediatricians prescribe? A survey among Israeli paediatricians.

abstract：:A single dose pharmacokinetic study was conducted on two sustained-release formulations (75 mg) of indomethacin (Indocid capsules 'A' and Indogesic tablets 'B'). The study was carried out on 22 healthy male volunteers, who received a single oral dose (75 mg) of each product according to a randomized crossover design. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hasan MM,Najib NM,Muti HY

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To report three cases of alopecia induced by the anticoagulant enoxaparin in cerebral venous thrombosis (CVT) patients. CASE SUMMARY:Three female patients were treated initially with direct intrasinus urokinase, and then followed by low-molecular-weight heparin (LMWH) enoxaparin at 1 mg/kg given subcutaneous...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang YY,Po HL

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To estimate the prevalence of potentially severe drug-drug interactions (DDIs) and their relationship with age, sex and number of prescribed drugs. METHODS:We analysed all prescriptions dispensed from 1 January 2003 to 31 December 2003 to individuals aged 65 or more registered under the Local Health Authority ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Nobili A,Pasina L,Tettamanti M,Lucca U,Riva E,Marzona I,Monesi L,Cucchiani R,Bortolotti A,Fortino I,Merlino L,Walter Locatelli G,Giuliani G

更新日期：2009-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin, a γ-aminobutyric acid derivative, is used for the treatment of partial onset seizures, postherpetic neuralgia, diabetic neuropathy and a host of other neurological disorders. CASE DESCRIPTION:A 44-year-old woman with spinal stenosis was prescribed gabapentin for pain. Two months...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tellor KB,Ngo-Lam R,Badran D,Armbruster AL,Schwarze MW

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To determine whether patients who are prescribed a highly active antiretroviral therapy regimen, that minimizes medical and lifestyle contraindications, will be better able to adhere to their drug regimens and will have better clinical outcomes, than patients who do not have such a regimen. METHODS:A retrosp...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lal LS,Grimes RM,Swint JM,Risser J

更新日期：2006-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Huang W,Li J,Qiu F,Wu X,Zhang J,Li X,Yao G,Zhu S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Two NS3/4A protease inhibitors (PIs), telaprevir and boceprevir, were recently approved in the United States. The primary objective was to compare the efficacy and safety of triple therapies including either PI to dual therapy in patients with chronic hepatitis C genotype 1; the secondary ob...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Park C,Jiang S,Lawson KA

更新日期：2014-02-01 00:00:00

abstract：:This study involved the mixing of 1:1 combinations of Bactroban (mupirocin) Ointment 2% with various cream, lotion, ointment, gel, solution and liquid soap formulations with storage at 37 degrees C for 60 days. The mixtures were assayed for mupirocin content at 0, 15, 30, 45 and 60 days using a high-pressure liquid ch...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jagota NK,Stewart JT,Warren FW,John PM

更新日期：1992-06-01 00:00:00

abstract：INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anton C,Cox AR,Watson RD,Ferner RE

更新日期：2003-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Thomas J,Christenson JK,Walker E,Baby KE,Peterson GM

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Antituberculosis drug-induced liver injury (ATLI) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Rifampin (RIF) has been reported to cause haemolysis due to the production of drug-dependent antibodies, and haemolysis results in an increased level o...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tao B,Yang M,Chen H,Pan H,Liu W,Yi H,Tang S

更新日期：2020-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Morphine is one of the most widely used opioid analgesics for controlling pain in cancer and post-operative patients. OBJECTIVE:This study aimed at finding a sensitive method for measuring morphine. METHOD:A one-step solid phase extraction was developed for extracting morphine from various samples, and mor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mashayekhi SO,Ghandforoush-Sattari M,Hain RD

更新日期：2008-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Lee SH,Kim JH

更新日期：2020-12-01 00:00:00

abstract：:In many countries, including The Netherlands, little is known about the overall prescribing patterns within hospitals. While individual hospitals have some data available, these are not pooled on a regional or national level. The available data consist of dispensing data that are neither patient-linked nor diagnosis-l...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Denig P,Haaijer-Ruskamp FM,Versluis A,Wesseling H

更新日期：1991-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) are at higher risk of thrombotic complications. Studies have indicated that patients with T2DM have impaired clopidogrel-induced antiplatelet effect. Ticagrelor and prasugrel are two latest generation P2Y12 inhibitors with advantageous platelet i...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shang LL,Guo DD,Zhao HY,Quan AJ,Cao PG

更新日期：2018-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S

更新日期：2011-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Demonstration of the utility of electronic medical records (EMRs) for pharmacovigilance (PV) has been highly anticipated. Analysis using appropriately selected EMRs should enable accurate estimation of adverse drug event (ADE) frequencies and thus promote appropriate regulatory actions. Stat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sai K,Hanatani T,Azuma Y,Segawa K,Tohkin M,Omatsu H,Makimoto H,Hirai M,Saito Y

更新日期：2013-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Current guidelines recommend a combination of clopidogrel and aspirin for management of patients who have experienced an acute coronary syndrome (ACS). Additional antiplatelet agents have been recently approved. Few comparative effectiveness studies are available for these new agents. Accord...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Olson WH,Ma YW,Laliberté F,Lefebvre P,Crivera C,Schein JR,Fields LE,Dea K,Germain G,Lynch SM

更新日期：2014-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence. COMMENT:Although interethnic differences in drug response are well known, there are no reliable epid...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shah RR

更新日期：2019-02-01 00:00:00

abstract：:Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jones AF,Vale JA

更新日期：1993-02-01 00:00:00

abstract：:The aim of the study was to determine the usage patterns of benzodiazepine hypnotics, the use of other ways of improving sleep and general sleep characteristics in patients prescribed these drugs on a regular basis and in a control group of age- and sex-matched patients not receiving hypnotics. Patients receiving regu...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Krska J,MacLeod TN

更新日期：1995-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to elucidate the pharmacokinetics of erlotinib in Japanese patients with advanced non-small cell lung cancer (NSCLC) and to investigate the relationship between erlotinib exposure and the occurrence of interstitial lung disease (ILD)-like events. METHODS:Population pharmaco...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Emoto-Yamamoto Y,Iida S,Kawanishi T,Fukuoka M

更新日期：2015-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feehan M,Walsh M,Godin J,Sundwall D,Munger MA

更新日期：2017-12-01 00:00:00

abstract：:Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patien...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sangrador G,Sánchez-Alcaraz A,Ubeda R,Ibañez P

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF). AIM:To evaluate the effects of a macrolide antibio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yalçin E,Kiper N,Ozçelik U,Doğru D,Firat P,Sahin A,Ariyürek M,Mocan G,Gürcan N,Göçmen A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:In early breast cancer patients the transformed epithelial cells are thought to be sensitive to transforming growth factor beta1 (TGFbeta1)-mediated growth arrest. TGFbeta1 may therefore act as an anti-tumour promoter. However, in advanced breast cancer resistance to such TGFbeta1 action develops. Neoplastic...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kajdaniuk D,Marek B,Swietochowska E,Ostrowska Z,Glogowska-Szelag J,Kos-Kudla B,Ciesielska-Kopacz N,Wielkoszyski T

更新日期：2000-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Baking soda is a common household product promoted by the manufacturer as an antacid. It contains sodium bicarbonate and has the potential for significant toxicity when ingested in excessive amounts. Characterizing the patterns and outcomes from the misuse of baking soda as a home remedy can...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Al-Abri SA,Kearney T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The anti-craving drug, naltrexone, is used as a pharmacotherapeutic adjunct in the treatment of alcohol dependence. In addictive disorders, compliance issues remain central. There are limited data on compliance with naltrexone treatment regimens within formalized rehabilitation programs and even less data th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feeney GF,Connor JP,Young RM,Tucker J,Czajkowski F

更新日期：2001-02-01 00:00:00