Therapeutic drug monitoring-based dose optimization for imatinib-associated serious cutaneous reactions in a patient with gastrointestinal stromal tumours: A case report.

abstract：BACKGROUND:The anti-craving drug, naltrexone, is used as a pharmacotherapeutic adjunct in the treatment of alcohol dependence. In addictive disorders, compliance issues remain central. There are limited data on compliance with naltrexone treatment regimens within formalized rehabilitation programs and even less data th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feeney GF,Connor JP,Young RM,Tucker J,Czajkowski F

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability. OBJECTIVE:To assess the physical compatibility and the chemical stability of nefopam hydrochloride, a centrally acting non-opioid analgesic, when admixed with selected proton pump inhibit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kambia NK,Luyckx M,Dine T,Dupin-Spriet T,Gressier B,Brunet C

更新日期：2009-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication sho...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pasina L,Urru SA,Mandelli S,Giua C,Minghetti P,SGCP Investigators.

更新日期：2016-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical use of fluconazole against fungal infections in renal transplant patients is complicated by the potentially marked and unpredictable drug-drug interactions (DDIs). We report a case of tacrolimus-fluconazole DDI in a stable renal transplant recipient and describe the mechanism, magni...

journal_title：Journal of clinical pharmacy and therapeutics

authors： He J,Yu Y,Yin C,Liu H,Zou H,Ma J,Yang W,Liu Y,Zhong L,Chen X

更新日期：2020-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Lorenzo-Pinto A,Giménez-Manzorro Á,Rodríguez-González CG,Ahumada-Jiménez A,Herranz-Alonso A,Marzal-Alfaro MB,Sanjurjo-Sáez M

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lee DG,Chae H,Yim DS,Park SH,Choi SM,Kim S,Choi JH,Yoo JH,Shin WS

更新日期：2009-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin has been used for the management of post-herpetic neuralgia (PHN). However, inconsistent results have been reported. This meta-analysis was performed to assess the efficacy and safety of gabapentin 1800 mg/day in PHN patients by conducting a meta-analysis. METHODS:Electronic data...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fan H,Yu W,Zhang Q,Cao H,Li J,Wang J,Shao Y,Hu X

更新日期：2014-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Although the risk of major bleeding with non-vitamin K antagonist oral anticoagulant (NOAC) is low, life-threatening bleeding can occur. CASE SUMMARY:We report a case of an 81-year-old female with deep vein thrombosis who developed bilateral spontaneous haemothorax and haemopericardium afte...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yu JH,Liu HH,Hsieh MJ,Hsieh IC,Chu PH,Chen DY

更新日期：2020-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. Secondary forms of the disease may be due to consumption of trimethylamine precursor-rich foods or metabolism of some xenobiotics. CASE SUMMARY:A HI...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scimone C,Alibrandi S,Donato L,Giofrè SV,Rao G,Sidoti A,D'Angelo R

更新日期：2020-11-28 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Little is known about the ability of community pharmacists who are inexperienced in medication review to identify drug-related problems (DRPs). The objective of our study was to investigate the completeness of DRPs in terms of number, type and clinical relevance identified by community phar...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kwint HF,Faber A,Gussekloo J,Bouvy ML

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To determine whether any demographic or socioeconomic factors affect the use of smoking cessation medications in patients hospitalized with heart disease. METHOD:Data were obtained from the Improving Cardiovascular Outcomes in Nova Scotia (ICONS) Canada database, which includes a registry of all hospitalized...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Whelan AM,Cooke CA,Sketris IS

更新日期：2005-04-01 00:00:00

abstract：:New treatments for relapse of acute myeloid leukaemia (AML), include gemtuzumab ozogamicin (GO), an anti-CD33 monoclonal antibody. We describe a second case of GO-induced sinusoidal obstructive syndrome (SOS) effectively treated with defibrotide (DF). No stem-cell transplantation was involved. On day 23 after the firs...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lannoy D,Decaudin B,Grozieux de Laguérenne A,Barrier F,Pignon JM,Wetterwald M,Odou P

更新日期：2006-08-01 00:00:00

abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jacobson GA,Peterson GM,McLean S

更新日期：1997-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Thiopurines are cornerstone drugs in the treatment of acute lymphoblastic leukaemia (ALL), but their use can be complicated by the incidence of life-threatening leucopenia. CASE DESCRIPTION:We describe a case of a 6-year-old Chinese boy with B-ALL receiving extremely low dose of 6-mercapto...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhai XY,Zhou Y,Dong L,Nie AQ,Zhi LJ,Jacqz-Aigrain E,Wang TY,Wang L,Zhao W

更新日期：2021-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. CASE DESCRIPTION:We present two cases of Lemierr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Le C,Gennaro D,Marshall D,Alaev O,Bryan A,Gelfman A,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0.05 M ammonium acetate buffer containing 0.01 M octane sulphona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shiekh Salem M,Gharaibeh AM,Alkaysi HN,Badwan A

更新日期：1988-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN:The neonatal intensive care units (NICUs) are at the highest risk of drug dose error of all hospital wards. NICUs also have the most complicated prescription modalities. The computerization of the prescription process is currently recommended to decrease the risk of preventable adverse drug effects (pADEs...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gouyon B,Iacobelli S,Saliba E,Quantin C,Pignolet A,Jacqz-Aigrain E,Gouyon JB

更新日期：2017-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Budesonide, an oral glucocorticoid indicated for the treatment of Crohn's disease, rarely interferes with the hypothalamic-pituitary-adrenal axis because more than 80% of it is metabolized by cytochrome P450 enzymes. CASE SUMMARY:A 33-year-old female patient diagnosed with Crohn's disease, ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Martin CS,Blaga C,Lambrescu IM,Fierbințeanu-Braticevici C,Fica S

更新日期：2015-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:One-third of patients with epilepsy are resistant to anti-epileptic drugs (AEDs). Drug-resistant epilepsy is believed to be multifactorial involving both genetic and non-genetic factors. Genetic variations in the ABCB1 gene encoding the drug efflux transporter, p-glycoprotein (p-gp), may inf...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Keangpraphun T,Towanabut S,Chinvarun Y,Kijsanayotin P

更新日期：2015-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinical pharmacokinetic profiles of clarithromycin and telithromycin in bronchopulmonary sites have not been fully characterized. This study aimed to describe in more detail the pharmacokinetics of the two macrolides in epithelial lining fluid (ELF) of human bronchi and to evaluate their ph...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ikawa K,Kikuchi E,Kikuchi J,Nishimura M,Derendorf H,Morikawa N

更新日期：2014-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cancer patients treated with cisplatin chemotherapy frequently experience drug-induced nephrotoxicity. Clinical studies using a single chemotherapeutic regimen or large sample sizes for patients with the SLC22A2 808T allele have not been reported. Here, we examined 95 patients with oesophage...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hinai Y,Motoyama S,Niioka T,Miura M

更新日期：2013-12-01 00:00:00

abstract：:Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffe...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Calatayud O,Rodríguez M,Sánchez-Alcaraz A,Ibáñez P

更新日期：1995-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) that has activity in several types of malignancies. One of the uncommon adverse effects is spontaneous bowel perforation. In patients who have undergone cystectomy, a loop of small bowel is often used...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Liu SV,Gollard R,Iqbal S

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kos-Kudła B,Ostrowska Z,Marek B,Ciesielska-Kopacz N,Sieminska L,Kajdaniuk D,Nowak M,Kudla M

更新日期：2000-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The current pharmacotherapeutic treatment of major depressive disorder (MDD) generally takes weeks to be effective. As the molecular action of these drugs is immediate, the mechanistic basis for this lag is unclear. A drug that has a more rapid onset of action would be a major therapeutic ad...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Drewniany E,Han J,Hancock C,Jones RL,Lim J,Nemat Gorgani N,Sperry JK 3rd,Yu HJ,Raffa RB

更新日期：2015-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Every prescriber knows that patients often do not take their medicines as prescribed. Hippocrates, the wise man of Kos, knew over two millennia ago. Our objective is to comment on the types of studies aimed at understanding and optimizing drug usage and to draw attention to the need to seek ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Li-Wan-Po A,Peterson GM

更新日期：2021-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION:We present a patient with schizophrenia who developed acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Omi T,Mitsui Y,Matsunaga H

更新日期：2018-02-01 00:00:00

abstract：:The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study wi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Molinaro M,Regazzi MB,Raffaghello S,Buggia I,Iacona I,Graziani P,Specchia G,Melzi D'eril G

更新日期：1994-04-01 00:00:00