Extremely low dose of 6-mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations.

abstract：WHAT IS KNOWN AND OBJECTIVE:Rutoside (rutin; quercetin rutinoside) is a glycoside found in various plant products, including apples, citrus fruits and cranberries. Hydroxyethylrutosides (HR) are semisynthetic derivatives sold as standardized products for the treatment of chronic venous insufficiency (CVI). Commercially...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Aziz Z,Tang WL,Chong NJ,Tho LY

更新日期：2015-04-01 00:00:00

abstract：:Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patien...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sangrador G,Sánchez-Alcaraz A,Ubeda R,Ibañez P

更新日期：1990-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Linezolid, a member of the oxazolidinone class of antibacterial drugs, is approved by the US Food and Drug Administration (FDA) for the treatment of vancomycin-resistant Enterococcus faecium infections, nosocomial and community-acquired pneumonia, as a part of anti tubercular regimen and com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Singhania SVK,Shenoy S,Kapoor D

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adverse drug events (ADE), common and underestimated in ICU patients, have direct consequences on length of stay, mortality and hospital costs. Critically ill patients with HIV/AIDS are at a high risk of ADE because of their need for multiple drug therapies. ADE can be prevented, especially ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ramos GV,Guaraldo L,Japiassú AM,Bozza FA

更新日期：2015-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Appraisal of drug information centres (DICs) is mainly by word of mouth communication and surveys of overall user satisfaction. Efforts to study the impact of this type of informatics and decision support systematically are generally lacking within the healthcare system. COMMENT:Scandinavia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Schjøtt J,Spigset O

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Emerging antibiotic resistance in common pathogens is a worldwide problem known to be related to inappropriate overuse of antibiotics. Wide variability in antibiotic use throughout the world is because of various factors, including socio-cultural differences. OBJECTIVE:To study the rate of antibiotic prescr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kumar R,Indira K,Rizvi A,Rizvi T,Jeyaseelan L

更新日期：2008-12-01 00:00:00

abstract：:The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study wi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Molinaro M,Regazzi MB,Raffaghello S,Buggia I,Iacona I,Graziani P,Specchia G,Melzi D'eril G

更新日期：1994-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to compare the ability of statin monotherapy (ST group), omega-3 fatty acid monotherapy (OM_A group) and combination therapy with omega-3 fatty acids and a statin (OM_S group), to reduce triglyceride (TG) levels in patients with hypertriglyceridaemia. METHODS:In this retros...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Jeong YJ,Yang SJ,Baik SJ,Lee H,Lee SH,Cho JH,Choi IY,Yim HW,Yoon KH

更新日期：2016-10-01 00:00:00

abstract：:Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metaboliz...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Schachter M

更新日期：1991-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long non-coding RNAs (lncRNAs) have been proved to regulate. LncRNA TUG1 is well characterized in cancer biology. This study was carried out to investigate the molecular function of lncRNA TUG1 in myocardial infarction. METHODS:This study enrolled 58 MI patients and 52 healthy volunteers, a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Li B,Wu Y

更新日期：2020-12-01 00:00:00

abstract：:The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Betz C,Mihalic D,Pinto ME,Raffa RB

更新日期：2000-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lu PH,Tseng JC,Chen CK,Chen CH

更新日期：2017-08-01 00:00:00

abstract：:Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffe...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Calatayud O,Rodríguez M,Sánchez-Alcaraz A,Ibáñez P

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Morgan O,Hawkins L,Edwards N,Dargan P

更新日期：2007-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Bisphosphonates are the first-line medications for treating osteoporosis. The aim of our prospective study was to compare the efficacy of zoledronate with that of alendronate in women with post-menopausal osteoporosis based on the evaluations of bone mineral density (BMD) and serum levels of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tan W,Sun J,Zhou L,Li Y,Wu X

更新日期：2016-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:With the ageing of the population also comes increasing comorbidities and the use of multiple medications and administration methods, along with greater susceptibility to adverse drug reactions. Dosage form modification to facilitate drug administration in older adults can be potentially pro...

journal_title：Journal of clinical pharmacy and therapeutics

authors： McDerby N,Kosari S,Bail K,Shield A,Peterson G,Naunton M

更新日期：2019-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication sho...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pasina L,Urru SA,Mandelli S,Giua C,Minghetti P,SGCP Investigators.

更新日期：2016-04-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The pharmacokinetic-pharmacodynamic parameter that best predicts the efficacy of vancomycin is the ratio of the area under the concentration versus time curve (AUC) to the minimum inhibitory concentration (MIC). A 24-h AUC (AUC24 )/MIC ratio ≥ 400 was recommended in an American consensus rev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fukumori S,Tsuji Y,Mizoguchi A,Kasai H,Ishibashi T,Iwamura N,To H

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Insomnia is a common complaint in the general population. Interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in Taiwan. We undertook a survey to define the drug utilization patterns of Chinese herbal medicines (CM) for insomnia in Taiwan....

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen LC,Chen IC,Wang BR,Shao CH

更新日期：2009-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRIs) are the first line of medication for OCD treatment; however, 40%-60% of patients with OCD do not respond to SSRIs adequately. There are growing pieces of evidence which...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abdolhosseinzadeh S,Sina M,Ahmadiani A,Asadi S,Shams J

更新日期：2019-02-01 00:00:00

abstract：:A drug use review of omeprazole was carried out at two centres in the Yorkshire Region from December 1990 to April 1991. Data collection documents were used and 66 patients in total were audited. Thirteen patients (19.7%) were treated for indications outside the product licence and 18 patients (27.3%) were treated for...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Norris CM,McManus PV,Petty D,Kay EA

更新日期：1992-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The most appropriate sedative agent for conscious sedation in minor hysteroscopic surgeries is still unclear. Dexmedetomidine a sedative and analgesic agent, may be appropriate for outpatient procedures. The aim of our study was to compare the sedative, analgesic and hemodynamic effects of d...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bingol Tanriverdi T,Koceroglu I,Devrim S,Gura Celik M

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:In paediatric pharmacotherapy, many drugs are prescribed to be given in ways and for conditions not approved in the marketing authorization (MA). Thus, off-label prescribing of drugs with no MA is widespread in paediatric wards. However, drug MA status and clinical practices differ across countries. In this ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lindell-Osuagwu L,Korhonen MJ,Saano S,Helin-Tanninen M,Naaranlahti T,Kokki H

更新日期：2009-06-01 00:00:00

abstract：WHAT IS KNOW AND OBJECTIVE:Teriflunomide is indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis. CASE SUMMARY:We present a rare intoxication with a high dose (672 mg) of teriflunomide. According to its product label, the only known treatment is the administration of colestyramine ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mian P,van Haaften WT,Assink M,van Drie-Pierik RJHM

更新日期：2021-01-09 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang D,Hao J,Hou R,Yu Y,Hu B,Wei L

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

更新日期：2000-10-01 00:00:00

abstract：:We examined a total of 192 samples, including eight different brands of shaving cream and eight brands of shampoo, for their total aerobic bacterial, coliforms and fungal counts. Shaving creams were more heavily contaminated with bacteria than shampoos. Viable bacterial were not recovered from 57% and 10% of shampoos ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abdelaziz AA,Ashour MS,Hefni H,el-Tayeb OM

更新日期：1989-02-01 00:00:00

abstract：:There has been much interest recently in the delivery of proteins and peptides following the research and development of biotechnology: derived drugs and other bioactive substances. This article summarizes the use of iontophoresis to deliver proteins and peptides across the skin. This technique offers considerable pro...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Parasrampuria D,Parasrampuria J

更新日期：1991-02-01 00:00:00