High-performance liquid chromatographic analysis of ranitidine in plasma and urine.

abstract：BACKGROUND AND OBJECTIVE:Although the kinetic behaviour of tramadol has been described, the present study is the first to our knowledge, to report specifically on the population pharmacokinetic modelling of tramadol hydrochloride. METHODS:The parametric Iterative Two-stage Bayesian Population Model (IT2B) program foll...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gan SH,Ismail R,Wan Adnan WA,Zulmi W,Jelliffe RW

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:The use of psychotropic drugs has increased continuously over recent years in industrialized countries. In Europe, France has the highest consumption of such drugs. The aim of this study was to identify the sociodemographic and medical factors associated with the use of psychotropic agents. METHODS:Data, co...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Empereur F,Baumann M,Alla F,Briançon S

更新日期：2003-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Admixtures of levobupivacaine, fentanyl and epinephrine are increasingly used in epidural pain management. Neither the compatibility nor the stability of levobupivacaine with fentanyl and epinephrine is known and therefore we examined the chemical, physical and microbiological stability of l...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Helin-Tanninen M,Lehtonen M,Naaranlahti T,Venäläinen T,Pentikäinen J,Laatikainen A,Kokki H

更新日期：2013-04-01 00:00:00

abstract：:Nineteen different brands of topical creams were tested in duplicate for microbial growth. The efficacy of their preservation was assessed, when possible, by standard pharmacopoeial procedures. Microbial growth was demonstrated in cultures from all specimens. However, high counts (> 10(4) c.f.u./g) were obtained from ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Na'was T,Alkofahi A

更新日期：1994-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： García-Molina Sáez C,Urbieta Sanz E,Madrigal de Torres M,Vicente Vera T,Pérez Cárceles MD

更新日期：2016-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Psoriatic arthritis is an autoimmune disease characterized by chronic inflammation of the skin and joints. Anti-TNF drugs reduce the severity of the disease in the long term. This study compares the efficacy and safety of adalimumab, etanercept, infliximab and golimumab in patients with psor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fénix-Caballero S,Alegre-del Rey EJ,Castaño-Lara R,Puigventós-Latorre F,Borrero-Rubio JM,López-Vallejo JF

更新日期：2013-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Subjects of different ethnic groups may respond differently to drugs. The present study was conducted to compare the oral pharmacokinetics of midazolam among healthy volunteers from five different ethnic groups in China: Han, Mongolian, Uygur, Hui and Korean. METHODS:Healthy volunteers (10...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Guo T,Mao GF,Xia DY,Su XY,Zhao LS

更新日期：2011-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The pharmacokinetic-pharmacodynamic parameter that best predicts the efficacy of vancomycin is the ratio of the area under the concentration versus time curve (AUC) to the minimum inhibitory concentration (MIC). A 24-h AUC (AUC24 )/MIC ratio ≥ 400 was recommended in an American consensus rev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fukumori S,Tsuji Y,Mizoguchi A,Kasai H,Ishibashi T,Iwamura N,To H

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is concern regarding long-term excess calcium intake in end-stage renal disease populations. Because calcium carbonate is an over-the-counter (OTC) medication, few studies have been able to track its use. The Veterans Health Administration (VA) tracks national pharmacy data for both OTC a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Borzecki AM,Lee A,Wang SW,Brenner L,Kazis LE

更新日期：2007-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lu PH,Tseng JC,Chen CK,Chen CH

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:In early breast cancer patients the transformed epithelial cells are thought to be sensitive to transforming growth factor beta1 (TGFbeta1)-mediated growth arrest. TGFbeta1 may therefore act as an anti-tumour promoter. However, in advanced breast cancer resistance to such TGFbeta1 action develops. Neoplastic...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kajdaniuk D,Marek B,Swietochowska E,Ostrowska Z,Glogowska-Szelag J,Kos-Kudla B,Ciesielska-Kopacz N,Wielkoszyski T

更新日期：2000-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality, and frequent exacerbations are associated with an increased risk of death, deterioration in lung function and reduced quality of life. Current Australian guidelines developed by the Lung Foun...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brownridge DJ,Zaidi STR

更新日期：2017-06-01 00:00:00

abstract：:A drug use review of omeprazole was carried out at two centres in the Yorkshire Region from December 1990 to April 1991. Data collection documents were used and 66 patients in total were audited. Thirteen patients (19.7%) were treated for indications outside the product licence and 18 patients (27.3%) were treated for...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Norris CM,McManus PV,Petty D,Kay EA

更新日期：1992-12-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00

abstract：:When assessing a health-care intervention the main question is--does it work? Often, a more difficult question needs to be answered--how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking,...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wiffen PJ,Moore RA

更新日期：1996-02-01 00:00:00

abstract：WHAT IS KNOWN:The increased risk of cardiovascular events in diabetic patients has been related to numerous metabolic and haemoreological factors. Some of these factors appear to be particularly evident during the post-prandial phases and to be related to peak plasma glucose level. AIM:To compare the effect of additio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Derosa G,Mereu R,D'Angelo A,Salvadeo SA,Ferrari I,Fogari E,Gravina A,Palumbo I,Maffioli P,Randazzo S,Cicero AF

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Morgan O,Hawkins L,Edwards N,Dargan P

更新日期：2007-10-01 00:00:00

abstract：:Midazolam concentration curves versus time were analysed in 10 otherwise healthy patients (ASA I-II) with inferior limb pathologies. The benzodiazepine was used as an adjuvant agent to epidural anaesthesia in view of its lower residual effect compared with other intravenous benzodiazepines. Midazolam pharmacokinetics...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sánchez-Alcaraz A,Sangrador G,Laguarda M,Quintana B

更新日期：1991-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increa...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Francesca Notarangelo M,Marziliano N,Antonietta Demola M,Pigazzani F,Guidorossi A,Angelica Merlini P,Ardissino D

更新日期：2012-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:To date, no case of headache has been reported with enoxaparin. We present the case of a 60-years-old man, who developed enoxaparin-induced throbbing headache and discuss the possible pharmacological mechanisms. We provide an analysis of enoxaparin-induced headache in three international da...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brusadelli T,Carnovale C,Gentili M,Borsadoli C,Speziali A,Perrone V,Pellegrino P,Antoniazzi S,Pozzi M,Radice S,Clementi E

更新日期：2015-06-01 00:00:00

abstract：:The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Betz C,Mihalic D,Pinto ME,Raffa RB

更新日期：2000-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Metronidazole is one of the drugs with a well-recognized potential to rarely cause acute pancreatitis. The relation of other drugs of the 5-aminoimidazole group (e.g. tinidazole) to acute pancreatitis remains unknown. For the treatment of protozoal infections, tinidazole may be considered as...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hegazi MO,Saleh F,John JE

更新日期：2015-10-01 00:00:00

abstract：:Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally acce...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Palikhe NS,Kim SH,Park HS

更新日期：2008-10-01 00:00:00

abstract：:A stability-indicating reversed phase high-performance liquid chromatographic assay for prazosin was developed to investigate the feasibility of a transdermal dosage form. The assay enabled detection of drug concentrations down to 0.05 microgram/ml and the quantification of the drug in both permeation fluids and in ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tenjarla SN,Tseggai A

更新日期：1992-02-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：:This study investigated chemical and pharmaceutical equivalence of 11 brands of pyrimethamine-sulphadoxine combination tablets sold on the Tanzanian market. Physical and chemical tests were performed for all the 11 brands. These tests included hardness test, friability, disintegration, dissolution, weight uniformity a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hebron Y,Tettey JN,Pournamdari M,Watson DG

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Insomnia is a common complaint in the general population. Interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in Taiwan. We undertook a survey to define the drug utilization patterns of Chinese herbal medicines (CM) for insomnia in Taiwan....

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen LC,Chen IC,Wang BR,Shao CH

更新日期：2009-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Edoxaban has three dose adjustment factors (creatinine clearance, 15-50 mL/min; body weight, 60 kg or less; and concomitant medication with potent P-glycoprotein inhibitors) to prevent bleeding that results from elevated blood concentrations of the drug. A dose reduction (from 60 to 30 mg/da...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Takase T,Ikesue H,Nakagawa H,Kinoshita M,Muroi N,Kitai T,Furukawa Y,Hashida T

更新日期：2020-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Recent reviews have shown that pharmacist-provided medication review in the elderly can improve clinical outcomes and reduce medication discrepancies compared with usual care. However, none determined whether these translate to improved humanistic and economic outcomes. This review sought to...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Loh ZW,Cheen MH,Wee HL

更新日期：2016-12-01 00:00:00