Abstract：
WHAT IS KNOWN AND OBJECTIVE:Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence. COMMENT:Although interethnic differences in drug response are well known, there are no reliable epidemiologic data to support the above claim. Available information on chlorpromazine suggests variable ethnic sensitivities to drug-induced agranulocytosis. Agranulocytosis induced by at least four drugs has been associated with variant HLA alleles. Preliminary evidence also suggests that the presence of specific variant HLA alleles may sensitize individuals to dipyrone-induced agranulocytosis. There are historical reasons to suspect that the three populations referred to may share some key genetic features, including the potentially culprit variant HLA alleles, that predispose them to dipyrone-induced agranulocytosis. WHAT IS NEW AND CONCLUSION:The possibility that the British, Irish and Scandinavians show higher susceptibility than other populations to dipyrone-induced agranulocytosis cannot be ruled out. If this complication is linked to specific HLA allele(s), populations with higher frequency of variant HLA allele(s) may be at a greater risk. If confirmed, screening for the risk allele may be useful in reducing the risk of dipyrone-induced agranulocytosis.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Shah RRdoi
10.1111/jcpt.12768subject
Has Abstractpub_date
2019-02-01 00:00:00pages
129-133issue
1eissn
0269-4727issn
1365-2710journal_volume
44pub_type
杂志文章abstract：:Enalapril was shown to have no effect on the serum potassium of patients (n = 16) already taking Frusemide and Amiloride. Furthermore, there was no difference in serum potassium levels of the group taking a combination of Enalapril, Frusemide and Amiloride when compared to a similar group of patients taking Frusemide ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1987.tb00543.x
更新日期：1987-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic e...
journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1111/j.1365-2710.2010.01224.x
更新日期：2011-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (ciclopirox) and specifically its olamine salt 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone 2-aminoethanol salt (ciclopirox olamine) are anti-fungal agents currently used for the treatment of mild to moderate cutaneous fungal infection. Our ob...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2010.01172.x
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abstract：WHAT IS KNOWN AND OBJECTIVE:We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. CASE SUMMARY DESCRIPTION:The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglycerid...
journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1111/jcpt.13042
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abstract：WHAT IS KNOWN AND OBJECTIVE:Neuraminidase inhibitors are important options for the treatment of infection by the influenza virus. For the treatment of severe influenza, parenteral administration of a neuraminidase inhibitor may be desirable. This study was conducted to evaluate the pharmacokinetic and safety profiles o...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12056
更新日期：2013-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:An imbalance in the genetically controlled pro- and anti-inflammatory cytokine production could potentially promote ongoing low-grade inflammation following an episode of acute gastroenteritis and, subsequently, could result in irritable bowel syndrome (IBS; post-infectious IBS, PI-IBS). Sin...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12775
更新日期：2019-04-01 00:00:00
abstract：:The stability and compatibility of anakinra (recombinant human interleukin-1 receptor antagonist) with ceftriaxone sodium in 0.9% sodium chloride or 5% dextrose injection was determined during a 4-h period at ambient room temperature and light. Anakinra was diluted in 0.9% sodium chloride or 5% dextrose to the concent...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.1997.95275952.x
更新日期：1997-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Two NS3/4A protease inhibitors (PIs), telaprevir and boceprevir, were recently approved in the United States. The primary objective was to compare the efficacy and safety of triple therapies including either PI to dual therapy in patients with chronic hepatitis C genotype 1; the secondary ob...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1111/jcpt.12106
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the reconstitution methods for the commercial amphotericin B preparation with respect to particulate contamination. METHODS:The particle counts in amphotericin B solutions reconstituted according to three different methods and amphotericin B fluids made with intravenous fluids af...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2001.00328.x
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment of infants and children, as well as elderly people, who are more sensitive to dosage errors. Previous studies revealed significant dosage inaccuracies with measuring...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2009.01082.x
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:A large number of structurally and functionally diverse compounds act as substrates or modulators of p-glycoprotein (p-gp). Some of them possess multiple drug resistance (MDR)-reversing activity, but only a small number of them have entered clinical study. In order to uncover the factors which exert a signifi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2710.2003.00487.x
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data. METHOD:The steady-state blood level data (n = 129) after repetitive oral administration in 71 hospitalized neonates were analysed using Nonlinear Mixed Effects Modellin...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2007.00833.x
更新日期：2007-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous. We describe a retired nurse with history of depression, who began to develop drug-seeking behaviour after her first receiving of an intramuscular (IM...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12142
更新日期：2014-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the preferred approved treatment options for people with type 2 diabetes (T2D) and inadequate glycaemic control. The objective of this review is to provide a general clinical overview of the similarities and differences in the ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/jcpt.13230
更新日期：2020-09-01 00:00:00
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journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2004.00555.x
更新日期：2004-06-01 00:00:00
abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1997.tb00005.x
更新日期：1997-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Current guidelines recommend a combination of clopidogrel and aspirin for management of patients who have experienced an acute coronary syndrome (ACS). Additional antiplatelet agents have been recently approved. Few comparative effectiveness studies are available for these new agents. Accord...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12209
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the usefulness of intervention in drug interactions of antiretroviral drugs with coadministered agents by a clinical pharmacist in outpatient HIV-treatment. METHODS:The study design included two intervention arms (A and B), which were both preceded by a control observation period. In arm A, a com...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2003.00541.x
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...
journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1046/j.1365-2710.2001.00371.x
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:The quality of 33 formulations of essential antimicrobial and antimalarial drugs (amoxicillin capsules, metronidazole tablets, sulfamethoxazole/trimethoprim tablets, quinine tablets and sulphadoxine/pyrimethamine tablets) marketed in Rwanda and Tanzania was assessed and the influence of tropical storage condi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2004.00568.x
更新日期：2004-08-01 00:00:00
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journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1046/j.1365-2710.1999.00221.x
更新日期：1999-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Bisphosphonates are the first-line medications for treating osteoporosis. The aim of our prospective study was to compare the efficacy of zoledronate with that of alendronate in women with post-menopausal osteoporosis based on the evaluations of bone mineral density (BMD) and serum levels of...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12429
更新日期：2016-10-01 00:00:00
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journal_title：Journal of clinical pharmacy and therapeutics
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doi：10.1111/j.1365-2710.2010.01208.x
更新日期：2011-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The most common complication of heparin therapy is bleeding. Allergic reactions to heparin are rare, and the mechanisms are poorly understood. We report on a case of acute systemic reaction after subcutaneous injections of a low-molecular-weight heparin (LMWH) in a patient with a genetic pre...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2710.2012.01360.x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To evaluate if once-daily dose (ODD) regimens of tobramycin attain pharmacodynamic goals using individualized pharmacokinetic monitoring of critically ill patients with creatinine clearance (Clcr) over 60 mL/min. METHODS:Fifty-one adult critically ill patients treated with intravenous tobramycin with ODD wer...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2003.00539.x
更新日期：2004-02-01 00:00:00
abstract：:Steroids are widely used in treating the relapse of multiple sclerosis. There is no place for long term steroid therapy of this disease. Current practice is a short course of high dose methylprednisolone which can be repeated after an interval, has proven safety and objectively accelerates recovery. ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验,评审
doi：10.1111/j.1365-2710.1994.tb00677.x
更新日期：1994-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12538
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. METHOD:Eleven healthy individuals (26-61 years of age) were evaluated at basel...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2710.2005.00658.x
更新日期：2005-08-01 00:00:00
abstract：:In this study, the serum vitamin E (total tocopherol) levels in patients with breast cancer (n = 100) and healthy controls (n = 70) were measured. The mean values for vitamin E were found to be 0.44 mg/100 ml in breast cancer patients and 1.108 mg/100 ml in controls. In the statistical evaluation, the vitamin E levels...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1995.tb00645.x
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF). AIM:To evaluate the effects of a macrolide antibio...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2710.2006.00708.x
更新日期：2006-02-01 00:00:00
