Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.

abstract：BACKGROUND:The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability. OBJECTIVE:To assess the physical compatibility and the chemical stability of nefopam hydrochloride, a centrally acting non-opioid analgesic, when admixed with selected proton pump inhibit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kambia NK,Luyckx M,Dine T,Dupin-Spriet T,Gressier B,Brunet C

更新日期：2009-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mohee K,Wheatcroft SB

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The penetration of generic drugs in the Greek pharmaceutical market is placed among the weakest in the EU. The Greek regulatory framework does not systematically support the development of this subsector and physicians are not provided with incentives for prescribing generics. The aim of this s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tsiantou V,Zavras D,Kousoulakou H,Geitona M,Kyriopoulos J

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Crane IM,Mulhern MG,Nema S

更新日期：2003-10-01 00:00:00

abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Maiorini AF,Gaunt MJ,Jacobsen TM,McKay AE,Waldman LD,Raffa RB

更新日期：2002-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Drug prescribing is an essential part of inpatient care, and prescription errors/omissions have the potential to lead to disastrous consequences. Paediatric inpatient prescribing is particularly sensitive to error due to the weight-adjusted dosing of many medications prescribed in the acute ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bolt R,Yates JM,Mahon J,Bakri I

更新日期：2014-02-01 00:00:00

abstract：:In many countries, including The Netherlands, little is known about the overall prescribing patterns within hospitals. While individual hospitals have some data available, these are not pooled on a regional or national level. The available data consist of dispensing data that are neither patient-linked nor diagnosis-l...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Denig P,Haaijer-Ruskamp FM,Versluis A,Wesseling H

更新日期：1991-12-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00

abstract：:When designing studies of the optimal use of antimicrobial drugs, it is important to define at an early stage, which outcome parameters to use. It must be clear to which category a parameter to be measured belongs: the structure, the process or a clinical outcome. Attention must be paid to the measurement scales as we...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Natsch S,Kullberg BJ,Hekster YA,van der Meer JW

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To determine whether any demographic or socioeconomic factors affect the use of smoking cessation medications in patients hospitalized with heart disease. METHOD:Data were obtained from the Improving Cardiovascular Outcomes in Nova Scotia (ICONS) Canada database, which includes a registry of all hospitalized...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Whelan AM,Cooke CA,Sketris IS

更新日期：2005-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's synd...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tolomeo M,Colomba C,Meli M,Cascio A

更新日期：2019-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adverse drug events (ADE), common and underestimated in ICU patients, have direct consequences on length of stay, mortality and hospital costs. Critically ill patients with HIV/AIDS are at a high risk of ADE because of their need for multiple drug therapies. ADE can be prevented, especially ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ramos GV,Guaraldo L,Japiassú AM,Bozza FA

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2.50 and 5.00 mg/ ml) over a 30-day period. METHOD:Hig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oustric-Mendes AC,Huart B,Le Hoang MD,Perrin-Rosset M,Pailler FM,Darbord JC,Prognon P,Gard C,Pradeau D

更新日期：1997-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Huang W,Li J,Qiu F,Wu X,Zhang J,Li X,Yao G,Zhu S

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Enteric-coated, delayed-release divalproex sodium requires multiple daily administrations and high adherence rate to prevent breakthrough seizures and control adverse effects. We evaluated the effect of missing one or two doses of divalproex for up to 24 h, followed by replacement and resumptio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dutta S,Reed RC

更新日期：2006-08-01 00:00:00

abstract：:This study investigated chemical and pharmaceutical equivalence of 11 brands of pyrimethamine-sulphadoxine combination tablets sold on the Tanzanian market. Physical and chemical tests were performed for all the 11 brands. These tests included hardness test, friability, disintegration, dissolution, weight uniformity a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hebron Y,Tettey JN,Pournamdari M,Watson DG

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:In paediatric pharmacotherapy, many drugs are prescribed to be given in ways and for conditions not approved in the marketing authorization (MA). Thus, off-label prescribing of drugs with no MA is widespread in paediatric wards. However, drug MA status and clinical practices differ across countries. In this ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lindell-Osuagwu L,Korhonen MJ,Saano S,Helin-Tanninen M,Naaranlahti T,Kokki H

更新日期：2009-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long non-coding RNAs (lncRNAs) have been proved to regulate. LncRNA TUG1 is well characterized in cancer biology. This study was carried out to investigate the molecular function of lncRNA TUG1 in myocardial infarction. METHODS:This study enrolled 58 MI patients and 52 healthy volunteers, a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Li B,Wu Y

更新日期：2020-12-01 00:00:00

abstract：:New treatments for relapse of acute myeloid leukaemia (AML), include gemtuzumab ozogamicin (GO), an anti-CD33 monoclonal antibody. We describe a second case of GO-induced sinusoidal obstructive syndrome (SOS) effectively treated with defibrotide (DF). No stem-cell transplantation was involved. On day 23 after the firs...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lannoy D,Decaudin B,Grozieux de Laguérenne A,Barrier F,Pignon JM,Wetterwald M,Odou P

更新日期：2006-08-01 00:00:00

abstract：:To dose the anticonvulsant phenytoin (PHT) in a clinical situation is difficult because of the non-linear metabolism of the drug. Therefore many techniques have been advocated to aid dosage adjustments based on a single-point PHT concentration determined at steady-state (ss). We retrospectively investigated six method...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Ohtsubo K,Aoyama T

更新日期：1988-08-01 00:00:00

abstract：:Steroids are widely used in treating the relapse of multiple sclerosis. There is no place for long term steroid therapy of this disease. Current practice is a short course of high dose methylprednisolone which can be repeated after an interval, has proven safety and objectively accelerates recovery. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Griffiths TD,Newman PK

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To estimate the prevalence of potentially severe drug-drug interactions (DDIs) and their relationship with age, sex and number of prescribed drugs. METHODS:We analysed all prescriptions dispensed from 1 January 2003 to 31 December 2003 to individuals aged 65 or more registered under the Local Health Authority ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Nobili A,Pasina L,Tettamanti M,Lucca U,Riva E,Marzona I,Monesi L,Cucchiani R,Bortolotti A,Fortino I,Merlino L,Walter Locatelli G,Giuliani G

更新日期：2009-08-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0.05 M ammonium acetate buffer containing 0.01 M octane sulphona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shiekh Salem M,Gharaibeh AM,Alkaysi HN,Badwan A

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:SB5 is a biosimilar to the reference adalimumab (ADL) currently in development. The primary study objective was to demonstrate pharmacokinetic (PK) equivalence of SB5 to European Union-sourced adalimumab (EU-ADL), and United States-sourced adalimumab (US-ADL) in healthy subjects. Safety, tol...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shin D,Lee Y,Kim H,Körnicke T,Fuhr R

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL). METHODS:A total of 770 steady-state serum concentration samples was analysed. These were collected during VPA therapy from 255 child...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Serrano BB,García Sánchez MJ,Otero MJ,Buelga DS,Serrano J,Domínguez-Gil A

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

更新日期：2000-10-01 00:00:00

abstract：:The paper describes an in-depth study of the parenteral fat emulsions, Intralipid 20% and Ivelip 20%. A large number of emulsion samples from separate containers and batches was sampled. The parameters measured were droplet size (both by photon correlation and laser diffraction), pH and zeta potential. These parameter...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Washington C,Koosha F,Davis SS

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Although the kinetic behaviour of tramadol has been described, the present study is the first to our knowledge, to report specifically on the population pharmacokinetic modelling of tramadol hydrochloride. METHODS:The parametric Iterative Two-stage Bayesian Population Model (IT2B) program foll...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gan SH,Ismail R,Wan Adnan WA,Zulmi W,Jelliffe RW

更新日期：2004-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Pain management for complex regional pain syndrome (CRPS) is challenging. When added to local anaesthetics, dexmedetomidine prolongs the duration of the block and improves analgesia. The effect of long-term dexmedetomidine use in the brachial plexus block (BPB) for CRPS is unknown. CASE DES...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kang SH,Sim WS,Park HJ,Moon JY,Seon HJ,Lee JY

更新日期：2020-04-01 00:00:00