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Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences.

Abstract：

OBJECTIVE:To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. METHOD:Eleven healthy individuals (26-61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. RESULTS:Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P=0.029). White cell counts (WCC) were also increased (P=0.043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P=0.006) indicative of an antioxidant effect. CONCLUSION:The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.

journal_name

J Clin Pharm Ther

journal_title

Journal of clinical pharmacy and therapeutics

authors

Agnew LL,Guffogg SP,Matthias A,Lehmann RP,Bone KM,Watson K

doi

10.1111/j.1365-2710.2005.00658.x

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

363-9

issue

4

eissn

0269-4727

issn

1365-2710

pii

JCP658

journal_volume

30

pub_type

临床试验,杂志文章

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