Plasma transforming growth factor beta1 in breast cancer patients treated with CMF chemotherapy.

abstract：WHAT IS KNOWN AND OBJECTIVE:The most appropriate sedative agent for conscious sedation in minor hysteroscopic surgeries is still unclear. Dexmedetomidine a sedative and analgesic agent, may be appropriate for outpatient procedures. The aim of our study was to compare the sedative, analgesic and hemodynamic effects of d...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bingol Tanriverdi T,Koceroglu I,Devrim S,Gura Celik M

更新日期：2019-04-01 00:00:00

abstract：:Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jones AF,Vale JA

更新日期：1993-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Niacin commonly causes cutaneous flushing, which is partially alleviated by laropiprant, a selective antagonist of prostaglandin D2 at the DP1 receptor. Here we report an unusually high incidence of exanthematous eruption associated with the use of the extended-release (ER) niacin/laropipran...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yang YL,Hu M,Chang M,Tomlinson B

更新日期：2013-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Corticosteroids are recommended by almost all international guidelines for the management of exacerbations of chronic obstructive pulmonary disease (COPD). Nevertheless, due to their side effects, there are still concerns regarding the use of systemic corticosteroids (SCs). The Global Initia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gu YL,Pang J,Sun ZX,Hu J,Sun Y,Wu XW,Guo JJ,Yang GS

更新日期：2020-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Ticagrelor is a reversibly binding and selective P2Y12 -receptor antagonist approved for the prevention of atherothrombotic events in patients with acute coronary syndromes. As bleeding events remain a hazard with antiplatelet therapy, this study investigated the effect of the vasopressin ag...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Teng R,Mitchell PD,Butler K

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Lorenzo-Pinto A,Giménez-Manzorro Á,Rodríguez-González CG,Ahumada-Jiménez A,Herranz-Alonso A,Marzal-Alfaro MB,Sanjurjo-Sáez M

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The quality of 33 formulations of essential antimicrobial and antimalarial drugs (amoxicillin capsules, metronidazole tablets, sulfamethoxazole/trimethoprim tablets, quinine tablets and sulphadoxine/pyrimethamine tablets) marketed in Rwanda and Tanzania was assessed and the influence of tropical storage condi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kayumba PC,Risha PG,Shewiyo D,Msami A,Masuki G,Ameye D,Vergote G,Ntawukuliryayo JD,Remon JP,Vervaet C

更新日期：2004-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin, a γ-aminobutyric acid derivative, is used for the treatment of partial onset seizures, postherpetic neuralgia, diabetic neuropathy and a host of other neurological disorders. CASE DESCRIPTION:A 44-year-old woman with spinal stenosis was prescribed gabapentin for pain. Two months...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tellor KB,Ngo-Lam R,Badran D,Armbruster AL,Schwarze MW

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S

更新日期：2011-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. CASE SUMMARY DESCRIPTION:The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglycerid...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ma S,Liu S,Wang Q,Chen L,Yang P,Sun H

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To compare aminoglycoside pharmacokinetics in African-Americans with normal renal function with published adult population values. DESIGN:An Institutional Review Board approved concurrent study. SETTING:The study was conducted at Howard University Hospital, Washington DC. SUBJECTS:All subjects had serum cr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oparaoji EC,Siram S,Elemihe U,Mezghebe HM,Cho T,Bashiri M,Piedrahita K,Pipalla RS

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scheele J,Diergarten K,Drevs J,Niazi FR

更新日期：2013-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication sho...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pasina L,Urru SA,Mandelli S,Giua C,Minghetti P,SGCP Investigators.

更新日期：2016-04-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0.05 M ammonium acetate buffer containing 0.01 M octane sulphona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shiekh Salem M,Gharaibeh AM,Alkaysi HN,Badwan A

更新日期：1988-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to elucidate the pharmacokinetics of erlotinib in Japanese patients with advanced non-small cell lung cancer (NSCLC) and to investigate the relationship between erlotinib exposure and the occurrence of interstitial lung disease (ILD)-like events. METHODS:Population pharmaco...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Emoto-Yamamoto Y,Iida S,Kawanishi T,Fukuoka M

更新日期：2015-04-01 00:00:00

abstract：:The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n = 50) or active ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Whitefield M,O'Kane CJ,Anderson S

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hernández-Abad VJ,Castañeda-Hernández G,García-Jiménez S,Marroquín-Segura R,Sánchez-González E

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability. OBJECTIVE:To assess the physical compatibility and the chemical stability of nefopam hydrochloride, a centrally acting non-opioid analgesic, when admixed with selected proton pump inhibit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kambia NK,Luyckx M,Dine T,Dupin-Spriet T,Gressier B,Brunet C

更新日期：2009-02-01 00:00:00

abstract：:In this study, the serum vitamin E (total tocopherol) levels in patients with breast cancer (n = 100) and healthy controls (n = 70) were measured. The mean values for vitamin E were found to be 0.44 mg/100 ml in breast cancer patients and 1.108 mg/100 ml in controls. In the statistical evaluation, the vitamin E levels...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Torun M,Akgül S,Sargin H

更新日期：1995-06-01 00:00:00

abstract：:A hypertensive crisis can be caused by many factors. Frequently, the mechanism involved is complex and highly variable among patients. Without drug therapy, this condition is associated with very high mortality and morbidity. There are a number of oral and intravenous hypotensive agents available, which can effectivel...

journal_title：Journal of clinical pharmacy and therapeutics

authors： McKindley DS,Boucher BA

更新日期：1994-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMME...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Imatoh T,Sai K,Saito Y

更新日期：2018-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality, and frequent exacerbations are associated with an increased risk of death, deterioration in lung function and reduced quality of life. Current Australian guidelines developed by the Lung Foun...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brownridge DJ,Zaidi STR

更新日期：2017-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lim HS,Chong YP,Noh YH,Jung JA,Kim YS

更新日期：2014-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Morphine is one of the most widely used opioid analgesics for controlling pain in cancer and post-operative patients. OBJECTIVE:This study aimed at finding a sensitive method for measuring morphine. METHOD:A one-step solid phase extraction was developed for extracting morphine from various samples, and mor...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mashayekhi SO,Ghandforoush-Sattari M,Hain RD

更新日期：2008-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Two NS3/4A protease inhibitors (PIs), telaprevir and boceprevir, were recently approved in the United States. The primary objective was to compare the efficacy and safety of triple therapies including either PI to dual therapy in patients with chronic hepatitis C genotype 1; the secondary ob...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Park C,Jiang S,Lawson KA

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to compare the ability of statin monotherapy (ST group), omega-3 fatty acid monotherapy (OM_A group) and combination therapy with omega-3 fatty acids and a statin (OM_S group), to reduce triglyceride (TG) levels in patients with hypertriglyceridaemia. METHODS:In this retros...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Jeong YJ,Yang SJ,Baik SJ,Lee H,Lee SH,Cho JH,Choi IY,Yim HW,Yoon KH

更新日期：2016-10-01 00:00:00

abstract：:The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Higuchi S,Aoyama T

更新日期：1992-08-01 00:00:00