Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation.


WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year after renal transplantation, CYP3A5 and CYP2C19 polymorphisms, biochemical parameters and coadministration with lansoprazole, influenced tacrolimus pharmacokinetics. METHODS:The pharmacokinetics of tacrolimus was studied 1 year after renal transplantation, in 75 recipients who were all receiving continuation treatment with 12-hourly oral tacrolimus, and 30 mg lansoprazole daily (Group 1; n = 20) or, 10 mg rabeprazole daily or no proton pump inhibitor (Group 2; n = 55). RESULTS:There were no significant differences in the dose-adjusted area under the plasma concentration-time curve (AUC(0-12)) and maximum plasma concentration (C(max)) of tacrolimus between CYP2C19 genotype groups, but there were significant differences between CYP3A5 genotypes groups (*1/*1 + *1/*3 vs. *3/*3 = 45·2 ± 20·0 vs. 71·0 ± 34·1 ng·h/mL/mg, P < 0·0001 and 6·3 ± 2·6 vs. 9·3 ± 7·0 ng/mL/mg, P = 0·0017, respectively) and between co-administration with and without lansoprazole (74·5 ± 34·0 vs. 52·4 ± 27·4 ng·h/mL/mg, P = 0·0054 and 10·9 ± 8·8 vs. 6·7 ± 3·0 ng/mL/mg, P = 0·0024, respectively). In a multiple regression analysis, the dose-adjusted AUC(0-12) and C(max) of tacrolimus were associated with CYP3A5*3/*3 and co-administration with lansoprazole. WHAT IS NEW AND CONCLUSION:CYP2C19 does not seem to contribute to the interaction between tacrolimus and lansoprazole. The long-term combination of tacrolimus and lansoprazole requires careful monitoring of patients with the CYP3A5*3/*3 genotype.


J Clin Pharm Ther


Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S




Has Abstract


2011-04-01 00:00:00












  • Ceftriaxone-associated renal toxicity in adults: a case report and recommendations for the management of such cases.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Shen-Hua W,Fan-Yi M,Qing-Ling Z,Li-Na Z,Li-Jun M

    更新日期:2016-06-01 00:00:00

  • Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1.36% and Dianeal PD1 3.86%).

    abstract:BACKGROUND AND OBJECTIVE:Moxifloxacin is a new fluorquinolone with broad-spectrum activity. It is suitable for treating peritonitis in peritoneal dialysis (PD) patients. The objective of this study was to test stability of moxifloxacin in PD solutions stored at different temperatures. METHODS:Dialysis solution bags we...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Fernández-Varón E,Marín P,Espuny A,Villamayor L,Escudero E,Cárceles C

    更新日期:2006-12-01 00:00:00

  • Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-ana...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Suksomboon N,Poolsup N,Punthanitisarn S

    更新日期:2016-04-01 00:00:00

  • Patient preferences for healthcare delivery through community pharmacy settings in the USA: A discrete choice study.

    abstract:WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Feehan M,Walsh M,Godin J,Sundwall D,Munger MA

    更新日期:2017-12-01 00:00:00

  • Adherence with naltrexone prescription advice in hospital outpatient alcohol rehabilitation programme.

    abstract:BACKGROUND:The anti-craving drug, naltrexone, is used as a pharmacotherapeutic adjunct in the treatment of alcohol dependence. In addictive disorders, compliance issues remain central. There are limited data on compliance with naltrexone treatment regimens within formalized rehabilitation programs and even less data th...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Feeney GF,Connor JP,Young RM,Tucker J,Czajkowski F

    更新日期:2001-02-01 00:00:00

  • Case report of perforation of an ileal neobladder after treatment of rectal cancer with bevacizumab and comment on mechanisms of intestinal perforation associated with bevacizumab.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) that has activity in several types of malignancies. One of the uncommon adverse effects is spontaneous bowel perforation. In patients who have undergone cystectomy, a loop of small bowel is often used...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Liu SV,Gollard R,Iqbal S

    更新日期:2012-10-01 00:00:00

  • Effect of various estimates of renal function on prediction of vancomycin concentration by the population mean and Bayesian methods.

    abstract:OBJECTIVE:Renal function was estimated in 129 elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) who were treated with vancomycin (VCM). The estimation was performed by substituting serum creatinine (SCR) measured enzymatically and a value converted using the Jaffe method into the Cockcroft-Gault ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Tsuji Y,Hiraki Y,Mizoguchi A,Sadoh S,Sonemoto E,Kamimura H,Karube Y

    更新日期:2009-08-01 00:00:00

  • Effect of food on the bioavailability of a slow-release theophylline formulation.

    abstract::A study was conducted in two groups of healthy volunteers to assess whether the time of administration (10 min before the meal versus 60 min after the meal) influences the pharmacokinetics and absorption kinetics of a slow-release theophylline product (Teonova). In the first group (Group A, n = 10), the drug was given...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Boner AL,Sette L,Messori A,Plebani M,Vallone G,Martini N

    更新日期:1988-02-01 00:00:00

  • Evaluation of two buflomedil tablet formulations in patients with atherosclerotic disease.

    abstract::The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study wi...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Molinaro M,Regazzi MB,Raffaghello S,Buggia I,Iacona I,Graziani P,Specchia G,Melzi D'eril G

    更新日期:1994-04-01 00:00:00

  • Serum creatinine levels during cardiac surgery: absence of effect by aminoglycosides.

    abstract::The literature indicates that the relative nephrotoxicities of the three drugs used in this investigation are gentamicin > tobramycin > or = netilmicin. Serum creatinine levels over time were used in an attempt to elucidate the situation. They varied widely in all three groups and in controls in theatre. No definite t...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bertram D,Summers R

    更新日期:1993-06-01 00:00:00

  • Treatment of irritable bowel syndrome.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The complexity and diversity of irritable bowel syndrome's (IBS) presentation make treatment difficult. Although there are reviews and guidelines for treating IBS, they focus on the efficacy of medications for IBS symptoms using high-priority endpoints, leaving those of lower priority largel...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Trinkley KE,Nahata MC

    更新日期:2011-06-01 00:00:00

  • Decitabine as a conditioning regimen in haploidentical stem cell transplantation for refractory acute myeloid leukaemia.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Chemotherapy can increase treatment-related mortality associated with future haematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukaemia (AML). There is usually insufficient time to find a suitable unrelated donor for these patients. We repor...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Zhang C,Chen XH,Liu J,Gao L,Liu Y,Gao L,Kong PY,Zhang X

    更新日期:2015-06-01 00:00:00

  • Advances in pharmacotherapy: treatment of hypertensive crisis.

    abstract::A hypertensive crisis can be caused by many factors. Frequently, the mechanism involved is complex and highly variable among patients. Without drug therapy, this condition is associated with very high mortality and morbidity. There are a number of oral and intravenous hypotensive agents available, which can effectivel...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: McKindley DS,Boucher BA

    更新日期:1994-06-01 00:00:00

  • Diphenhydramine dependence through deep intramuscular injection resulting in myonecrosis and prolonged QT interval.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous. We describe a retired nurse with history of depression, who began to develop drug-seeking behaviour after her first receiving of an intramuscular (IM...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Chen TY,Yeh YW,Kuo SC,Chen CY,Lin TP,Chang CC

    更新日期:2014-06-01 00:00:00

  • Intraosseous administration of 4-factor prothrombin complex concentrate prior to emergent surgery after receiving apixaban.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The 4-factor prothrombin complex concentrate (4F-PCC) may be used to emergently achieve haemostasis in patients on anticoagulation prior to surgery. Limited data exist using the intraosseous route of administration of 4F-PCC in patients taking factor Xa inhibitors. CASE DESCRIPTION:We descr...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Ratliff P,Nutley K,Schroeder W,Cottingham L

    更新日期:2020-06-01 00:00:00

  • The role of NAT2 polymorphism and methylation in anti-tuberculosis drug-induced liver injury in Mongolian tuberculosis patients.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Zhang D,Hao J,Hou R,Yu Y,Hu B,Wei L

    更新日期:2020-06-01 00:00:00

  • Population pharmacokinetics of ABT-594 in subjects with diabetic peripheral neuropathic pain.

    abstract:WHAT IS KNOWN AND OBJECTIVE:ABT-594 is a non-opioid, non-NSAID analgesic. The objective of this work was to characterize the population pharmacokinetics of ABT-594 in subjects with neuropathic pain. METHODS:Efficacy, safety and pharmacokinetics of ABT-594 in subjects with painful diabetic polyneuropathy were evaluated...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dutta S,Awni W

    更新日期:2012-08-01 00:00:00

  • Evaluation of the quality of four Mexican drug products containing sodium naproxen.

    abstract:BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Hernández-Abad VJ,Castañeda-Hernández G,García-Jiménez S,Marroquín-Segura R,Sánchez-González E

    更新日期:2008-06-01 00:00:00

  • Hyperprolactinemia and amenorrhea associated with olanzapine normalized after addition of aripiprazole.

    abstract::Hyperprolactinemia is a frequent side-effect in the use of atypical antipsychotics. The propensity to induce hyperprolactinemia is highly substance dependent and hyperprolactinemia is not always associated with clinical side-effects. We report a case in which hyperprolactinemia and amenorrhea under the treatment with ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Wolf J,Fiedler U

    更新日期:2007-04-01 00:00:00

  • Serum vitamin E level in patients with breast cancer.

    abstract::In this study, the serum vitamin E (total tocopherol) levels in patients with breast cancer (n = 100) and healthy controls (n = 70) were measured. The mean values for vitamin E were found to be 0.44 mg/100 ml in breast cancer patients and 1.108 mg/100 ml in controls. In the statistical evaluation, the vitamin E levels...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Torun M,Akgül S,Sargin H

    更新日期:1995-06-01 00:00:00

  • Association of ABO blood group and antituberculosis drug-induced liver injury: A case-control study from a Chinese Han population.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Antituberculosis drug-induced liver injury (ATLI) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Rifampin (RIF) has been reported to cause haemolysis due to the production of drug-dependent antibodies, and haemolysis results in an increased level o...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Tao B,Yang M,Chen H,Pan H,Liu W,Yi H,Tang S

    更新日期:2020-08-01 00:00:00

  • Use of Tris-hydroxymethyl aminomethane in severe lactic acidosis due to highly active antiretroviral therapy: a case report.

    abstract:BACKGROUND:Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HI...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Marfo K,Garala M,Kvetan V,Gasperino J

    更新日期:2009-02-01 00:00:00

  • Qualitative studies on alpha-interferon-2b in prolonged continuous infusion regimes using gradient elution high-performance liquid chromatography.

    abstract::The treatment of home-based cancer patients with continuous infusion chemotherapy requires that complete courses of medication in pre-filled syringes are provided on an out-patient basis. The infusion must remain stable prior to use during refrigerated storage (up to 14 days) and during infusion from holster-worn ambu...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Palmer AJ,Sewell GJ,Rowland CG

    更新日期:1988-06-01 00:00:00

  • Management of acute coronary syndrome in a tertiary care general medical unit in Sri Lanka: how closely do we follow the guidelines?

    abstract:BACKGROUND AND OBJECTIVES:Acute coronary syndrome (ACS) is a leading cause of death. Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines. STUDY METHOD...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Rajapakse S,Rodrigo PC,Selvachandran J

    更新日期:2010-08-01 00:00:00

  • Evaluation of an information booklet for general practitioners with patients on home parenteral nutrition.

    abstract::An information package was developed for general practitioners (GPs) involved in the management of home parenteral nutrition (HPN) patients. The booklet covered five major sections: background information; HPN training; complications of HPN; arrangements for a particular patient; and hospital management of HPN. This s...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Malone M

    更新日期:1988-12-01 00:00:00

  • Comparison of antibiotic susceptibility in viridans group streptococci in low and high antibiotic-prescribing General Practices.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Antibiotic resistance has become a global public health issue. Most antibiotics are prescribed in the community, although there is less stewardship of such agents in the community compared to secondary and tertiary care. Few studies have attempted to examine the prescribing practices in Gene...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Goldsmith CE,Hara Y,Sato T,Nakajima T,Nakanishi S,Mason C,Moore JE,Matsuda M,Coulter WA

    更新日期:2015-04-01 00:00:00

  • Evaluation of pregabalin-induced adverse events related to falls using the FDA adverse event reporting system and Japanese Adverse Drug Event Report databases.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

    更新日期:2019-04-01 00:00:00

  • Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors.

    abstract:OBJECTIVE:A large number of structurally and functionally diverse compounds act as substrates or modulators of p-glycoprotein (p-gp). Some of them possess multiple drug resistance (MDR)-reversing activity, but only a small number of them have entered clinical study. In order to uncover the factors which exert a signifi...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Wang RB,Kuo CL,Lien LL,Lien EJ

    更新日期:2003-06-01 00:00:00

  • The influence of Rx-to-OTC changes on drug sales. Experiences from Sweden 1980-1994.

    abstract:OBJECTIVE:A descriptive study of national sales data from Sweden to find out the effect of over-the-counter (OTC) switches on total sales of a number of drugs. During the period 1980-94, 16 drugs were changed from prescription only (Rx) status to the Swedish OTC market. Total sales increased for 14 out of these 16 drug...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Carlsten A,Wennberg M,Bergendal L

    更新日期:1996-12-01 00:00:00

  • Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Moringa oleifera (MO) Lam (Moringaceae) is commonly used as food supplement and as medicine in most African countries where malaria is also endemic. Therefore, co-administration of MO with antimalarials is a possibility. This study investigated the effects of MO leaves powder on the pharmaco...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Olawoye OS,Adeagbo BA,Bolaji OO

    更新日期:2018-10-01 00:00:00