Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation.


WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year after renal transplantation, CYP3A5 and CYP2C19 polymorphisms, biochemical parameters and coadministration with lansoprazole, influenced tacrolimus pharmacokinetics. METHODS:The pharmacokinetics of tacrolimus was studied 1 year after renal transplantation, in 75 recipients who were all receiving continuation treatment with 12-hourly oral tacrolimus, and 30 mg lansoprazole daily (Group 1; n = 20) or, 10 mg rabeprazole daily or no proton pump inhibitor (Group 2; n = 55). RESULTS:There were no significant differences in the dose-adjusted area under the plasma concentration-time curve (AUC(0-12)) and maximum plasma concentration (C(max)) of tacrolimus between CYP2C19 genotype groups, but there were significant differences between CYP3A5 genotypes groups (*1/*1 + *1/*3 vs. *3/*3 = 45·2 ± 20·0 vs. 71·0 ± 34·1 ng·h/mL/mg, P < 0·0001 and 6·3 ± 2·6 vs. 9·3 ± 7·0 ng/mL/mg, P = 0·0017, respectively) and between co-administration with and without lansoprazole (74·5 ± 34·0 vs. 52·4 ± 27·4 ng·h/mL/mg, P = 0·0054 and 10·9 ± 8·8 vs. 6·7 ± 3·0 ng/mL/mg, P = 0·0024, respectively). In a multiple regression analysis, the dose-adjusted AUC(0-12) and C(max) of tacrolimus were associated with CYP3A5*3/*3 and co-administration with lansoprazole. WHAT IS NEW AND CONCLUSION:CYP2C19 does not seem to contribute to the interaction between tacrolimus and lansoprazole. The long-term combination of tacrolimus and lansoprazole requires careful monitoring of patients with the CYP3A5*3/*3 genotype.


J Clin Pharm Ther


Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S




Has Abstract


2011-04-01 00:00:00












  • Stability of reconstituted parecoxib for injection with commonly used diluents.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Crane IM,Mulhern MG,Nema S

    更新日期:2003-10-01 00:00:00

  • Patient preferences for healthcare delivery through community pharmacy settings in the USA: A discrete choice study.

    abstract:WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Feehan M,Walsh M,Godin J,Sundwall D,Munger MA

    更新日期:2017-12-01 00:00:00

  • In vitro dissolution studies on nifedipine capsules.

    abstract::The in vitro dissolution rates of 5 and 10 mg nifedipine capsules from eight suppliers were measured in simulated gastric fluid using the rotating paddle apparatus. A total of fourteen products were tested and the performance was found to be satisfactory for all products (> 80% dissolution in 20 min). ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Mehta AC,Hart-Davies S,Kay EA

    更新日期:1995-08-01 00:00:00

  • Does levodopa improve swallowing dysfunction in Parkinson's disease patients?

    abstract:OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析


    authors: Menezes C,Melo A

    更新日期:2009-12-01 00:00:00

  • Steroids in multiple sclerosis.

    abstract::Steroids are widely used in treating the relapse of multiple sclerosis. There is no place for long term steroid therapy of this disease. Current practice is a short course of high dose methylprednisolone which can be repeated after an interval, has proven safety and objectively accelerates recovery. ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审


    authors: Griffiths TD,Newman PK

    更新日期:1994-08-01 00:00:00

  • Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single-dose intravenous administration in healthy Chinese volunteers.

    abstract:OBJECTIVE:To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P-glycoprotein (P-gp), after single-dose i.v. infusion in healthy Chinese volunteers. METHODS:We conducted a randomized, dose-escalating, phase I clinical study for that purpose. Thirty healthy subjects rec...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Zheng L,Qing YP,Xu N,Yu Q,Wang Y,Wang FP,Li ZY

    更新日期:2010-02-01 00:00:00

  • Radical scavenging activity of bisbenzylisoquinoline alkaloids and traditional prophylactics against chemotherapy-induced oral mucositis.

    abstract:BACKGROUND AND OBJECTIVE:Oral mucositis is a major severe toxic side-effect of systemic chemotherapy and irradiation in patients with cancer. Various free radical scavengers have been shown to prevent chemotherapy-induced skin necrosis. The objective of this study was to determine the antioxidant activity of a bisbenzy...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Kaji H,Inukai Y,Maiguma T,Ono H,Teshima D,Hiramoto K,Makino K

    更新日期:2009-04-01 00:00:00

  • Drug-induced parotitis.

    abstract::Drug-induced parotitis is a relatively uncommon adverse drug reaction. Most of the data on drug-induced parotitis consist of isolated case reports with few attempts at rechallenge to confirm the aetiology. Phenylbutazone and oxyphenbutazone have a significant number of reports suggesting that these drugs may be implic...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Thompson DF

    更新日期:1993-08-01 00:00:00

  • Chemoradiation combined with regional hyperthermia for advanced oesophageal cancer: a systematic review and meta-analysis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radia...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Hu Y,Li Z,Mi DH,Cao N,Zu SW,Wen ZZ,Yu XL,Qu Y

    更新日期:2017-04-01 00:00:00

  • An assessment of dose-uniformity of samples delivered from paediatric oral droppers.

    abstract:BACKGROUND AND OBJECTIVES:To assess the accuracy and precision of delivery from containers containing oral drops, both under optimal laboratory conditions and during use by volunteers using a variety of real pharmaceutical products and specially prepared fluids. METHODS:The effects of the physical properties (viscosit...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Brown D,Ford JL,Nunn AJ,Rowe PH

    更新日期:2004-12-01 00:00:00

  • Multiple inductive effects of carbamazepine on combined therapy with paliperidone and amlodipine.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Carbamazepine is a potent inducer of cytochrome P450 3A and P-glycoprotein. However, there are no reports of the effects of carbamazepine on more than one co-administered drug. CASE SUMMARY:A 53-year-old female patient with schizophrenia and hypertension was on paliperidone 12 mg/day and am...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Akamine Y,Uehara H,Miura M,Yasui-Furukori N,Uno T

    更新日期:2015-08-01 00:00:00

  • The safety of spironolactone treatment in patients with heart failure.

    abstract:INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Anton C,Cox AR,Watson RD,Ferner RE

    更新日期:2003-08-01 00:00:00

  • Acute teriflunomide overdose with relatively mild symptoms: A case report.

    abstract:WHAT IS KNOW AND OBJECTIVE:Teriflunomide is indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis. CASE SUMMARY:We present a rare intoxication with a high dose (672 mg) of teriflunomide. According to its product label, the only known treatment is the administration of colestyramine ...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Mian P,van Haaften WT,Assink M,van Drie-Pierik RJHM

    更新日期:2021-01-09 00:00:00

  • Microbial contamination and preservative efficacy of topical creams.

    abstract::Nineteen different brands of topical creams were tested in duplicate for microbial growth. The efficacy of their preservation was assessed, when possible, by standard pharmacopoeial procedures. Microbial growth was demonstrated in cultures from all specimens. However, high counts (> 10(4) c.f.u./g) were obtained from ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Na'was T,Alkofahi A

    更新日期:1994-02-01 00:00:00

  • Factors limiting adherence to antiepileptic treatment: A French online patient survey.

    abstract:WHAT IS KNOWN AND OBJECTIVE:There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex tre...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Laville F,Montana M,Roux N,Rathelot P,Giorgi R,Vanelle P

    更新日期:2018-02-01 00:00:00

  • Compatibility of ropivacaine with morphine, sufentanil, fentanyl, or clonidine.

    abstract:BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Oster Svedberg K,McKenzie J,Larrivee-Elkins C

    更新日期:2002-02-01 00:00:00

  • Pharmacogenomic information in the Warning section of drug labels: A comparison between labels in the United States and those in five other countries/regions.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMME...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Imatoh T,Sai K,Saito Y

    更新日期:2018-08-01 00:00:00

  • Direct and indirect comparison of the efficacy and safety of adalimumab, etanercept, infliximab and golimumab in psoriatic arthritis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Psoriatic arthritis is an autoimmune disease characterized by chronic inflammation of the skin and joints. Anti-TNF drugs reduce the severity of the disease in the long term. This study compares the efficacy and safety of adalimumab, etanercept, infliximab and golimumab in patients with psor...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Fénix-Caballero S,Alegre-del Rey EJ,Castaño-Lara R,Puigventós-Latorre F,Borrero-Rubio JM,López-Vallejo JF

    更新日期:2013-08-01 00:00:00

  • New medicines in primary care: a review of influences on general practitioner prescribing.

    abstract:BACKGROUND AND OBJECTIVE:The uptake of new medicines is slower in the UK than in many other countries. Previous research found that cost and price have little influence on general practitioner (GP) behaviour, but recent UK government policy may have heightened cost-consciousness. Focussing on new medicines, this review...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Mason A

    更新日期:2008-02-01 00:00:00

  • Determinants of prescribing costs amongst single-handed general practitioners.

    abstract:OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Gill PS,Roalfe A

    更新日期:2001-12-01 00:00:00

  • Application of dynamic laser scattering to the quality control of injectable drugs: polymer formation in ampicillin solution.

    abstract:OBJECTIVE:To assess the usefulness of dynamic laser scattering for monitoring the stability of ampicillin after reconstitution from commercially available vials with respect to the polymer formation and potency. METHODS:Polymer formation and the remaining potency of the reconstituted ampicillin solution were estimated...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Sendo T,Teshima D,Makino K,Mishima K,Itoh Y,Oishi R

    更新日期:2002-04-01 00:00:00

  • A randomized controlled trial of a new ovule formulation of ornidazole for the treatment of bacterial vaginosis.

    abstract:OBJECTIVE:To compare the efficacy of 500 mg ornidazole vaginal ovules (VO) and vaginal tablets (VT) in the treatment of bacterial vaginosis. METHOD:Patients were allocated at random to one group of 50 subjects to be treated with a VO (500 mg) prepared in our laboratory and to a second group of 50 subjects to be treate...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baloğlu E,Ozyazici M,Baloğlu A,Ova L

    更新日期:2003-04-01 00:00:00

  • Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Upper respiratory tract infections (URTI) frequently cause exacerbations of chronic-obstructive pulmonary disease (COPD). Stimulation of the innate immune system may provide an early defence against such infections. The objective of this study was to determine whether Echinacea purpurea (EP)...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Isbaniah F,Wiyono WH,Yunus F,Setiawati A,Totzke U,Verbruggen MA

    更新日期:2011-10-01 00:00:00

  • Management of acute coronary syndrome in a tertiary care general medical unit in Sri Lanka: how closely do we follow the guidelines?

    abstract:BACKGROUND AND OBJECTIVES:Acute coronary syndrome (ACS) is a leading cause of death. Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines. STUDY METHOD...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Rajapakse S,Rodrigo PC,Selvachandran J

    更新日期:2010-08-01 00:00:00

  • Piracetam in the treatment of schizophrenia: implications for the glutamate hypothesis of schizophrenia.

    abstract:OBJECTIVE:There is a growing interest in investigating the role of glutamate receptors in the pathophysiology of schizophrenia. Indeed, the hyperdopaminergic theory of schizophrenia can explain only the positive symptoms of schizophrenia, whereas the glutamate hypothesis may provide a more comprehensive view of the ill...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Noorbala AA,Akhondzadeh S,Davari-Ashtiani R,Amini-Nooshabadi H

    更新日期:1999-10-01 00:00:00

  • Demonstrating effectiveness--the concept of numbers-needed-to-treat.

    abstract::When assessing a health-care intervention the main question is--does it work? Often, a more difficult question needs to be answered--how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking,...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Wiffen PJ,Moore RA

    更新日期:1996-02-01 00:00:00

  • Evaluation of an information booklet for general practitioners with patients on home parenteral nutrition.

    abstract::An information package was developed for general practitioners (GPs) involved in the management of home parenteral nutrition (HPN) patients. The booklet covered five major sections: background information; HPN training; complications of HPN; arrangements for a particular patient; and hospital management of HPN. This s...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Malone M

    更新日期:1988-12-01 00:00:00

  • Rapid-onset antidepressant action of ketamine: potential revolution in understanding and future pharmacologic treatment of depression.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The current pharmacotherapeutic treatment of major depressive disorder (MDD) generally takes weeks to be effective. As the molecular action of these drugs is immediate, the mechanistic basis for this lag is unclear. A drug that has a more rapid onset of action would be a major therapeutic ad...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Drewniany E,Han J,Hancock C,Jones RL,Lim J,Nemat Gorgani N,Sperry JK 3rd,Yu HJ,Raffa RB

    更新日期:2015-04-01 00:00:00

  • Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Cytochrome P450 1A2 (CYP1A2), CYP2B6 and inducible nitric oxide synthase (iNOS) are involved in the metabolism and action of many important therapeutic drugs, and genetic variants have been associated with interethnic differences in response to treatment, including chemotherapy. METHODS:Eig...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Qi GZ,Zhang ZY,Wang X,Yin SJ,Lou YQ,Zhang GL

    更新日期:2016-02-01 00:00:00

  • Ceftriaxone-associated renal toxicity in adults: a case report and recommendations for the management of such cases.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Shen-Hua W,Fan-Yi M,Qing-Ling Z,Li-Na Z,Li-Jun M

    更新日期:2016-06-01 00:00:00