Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1.36% and Dianeal PD1 3.86%).

abstract：OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gill PS,Roalfe A

更新日期：2001-12-01 00:00:00

abstract：:A single dose pharmacokinetic study was conducted on two sustained-release formulations (75 mg) of indomethacin (Indocid capsules 'A' and Indogesic tablets 'B'). The study was carried out on 22 healthy male volunteers, who received a single oral dose (75 mg) of each product according to a randomized crossover design. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hasan MM,Najib NM,Muti HY

更新日期：1994-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adherence to evidence-based drug therapy after acute myocardial infarction has increased over the last decades, but is still unsatisfactory. Our objectives are to set out to analyse patterns of evidence-based drug therapy after acute myocardial infarction (AMI), and evaluating socio-demograp...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kirchmayer U,Agabiti N,Belleudi V,Davoli M,Fusco D,Stafoggia M,Arcà M,Barone AP,Perucci CA

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring of clozapine as an aid in the treatment of schizophrenic states is commonly used in our hospital. OBJECTIVE:Development of a high-performance liquid chromatographic method for the determination of clozapine (CLZ) and its major metabolite desmethylclozapine (DMCLZ) in plasma and s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dumortier G,Lochu A,Zerrouk A,Van Nieuwenhuyse V,Colen de Melo P,Roche Rabreau D,Degrassat K

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Different population pharmacokinetics (PPK) models of tacrolimus have been established in various populations. However, the tacrolimus PPK model in paediatric systemic lupus erythematosus (PSLE) is still undefined. This study aimed to establish the tacrolimus PPK model in Chinese PSLE. MET...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang DD,Lu JM,Li Q,Li ZP

更新日期：2018-08-01 00:00:00

abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Maiorini AF,Gaunt MJ,Jacobsen TM,McKay AE,Waldman LD,Raffa RB

更新日期：2002-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Serum sialic acid is a recently investigated potential risk-marker for cardiovascular complications. There is a known association between sialic acid and cardiovascular complications in diabetes mellitus. We aimed to investigate the effect of antidiabetic drugs on the serum concentration of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rahman IU,Malik SA,Bashir M,Khan RU,Idrees M

更新日期：2010-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： García-Molina Sáez C,Urbieta Sanz E,Madrigal de Torres M,Vicente Vera T,Pérez Cárceles MD

更新日期：2016-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Beginning in the 1950s, a family of potent opioids was synthesized and developed (fentanyl and analogues). They continue to serve as valuable analgesic agents. But the recent spike and notoriety of their abuse has raised alarm, even calls for tighter control. We review the trajectory of thes...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Raffa RB,Pergolizzi JV Jr,LeQuang JA,Taylor R Jr,NEMA Research Group.,Colucci S,Annabi MH

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of intervention in drug interactions of antiretroviral drugs with coadministered agents by a clinical pharmacist in outpatient HIV-treatment. METHODS:The study design included two intervention arms (A and B), which were both preceded by a control observation period. In arm A, a com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Maat MM,de Boer A,Koks CH,Mulder JW,Meenhorst PL,van Gorp EC,Mairuhu AT,Huitema AD,Beijnen JH

更新日期：2004-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Both metformin and acarbose are recommended monotherapy and add-on therapy in type 2 diabetes mellitus (T2DM). A fixed-dose combination (FDC) of acarbose and metformin has been developed to reduce pill burden and potentially improve compliance. The current study investigated the bioequivalen...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim S,Jang IJ,Shin D,Shin DS,Yoon S,Lim KS,Yu KS,Li J,Zhang H,Liu Y,Brendel E,Blode H,Wang Y

更新日期：2014-08-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：:This study involved the mixing of 1:1 combinations of Bactroban (mupirocin) Ointment 2% with various cream, lotion, ointment, gel, solution and liquid soap formulations with storage at 37 degrees C for 60 days. The mixtures were assayed for mupirocin content at 0, 15, 30, 45 and 60 days using a high-pressure liquid ch...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jagota NK,Stewart JT,Warren FW,John PM

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Morgan O,Hawkins L,Edwards N,Dargan P

更新日期：2007-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent ev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mohee K,Wheatcroft SB

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is concern regarding long-term excess calcium intake in end-stage renal disease populations. Because calcium carbonate is an over-the-counter (OTC) medication, few studies have been able to track its use. The Veterans Health Administration (VA) tracks national pharmacy data for both OTC a...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Borzecki AM,Lee A,Wang SW,Brenner L,Kazis LE

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Information about the pharmacokinetics of digoxin in paediatric patients is limited. We therefore aimed to investigate the effects of physiological factors on the digoxin clearance in Japanese paediatric patients. METHOD:We used routinely collected therapeutic drug monitoring data (n=544), de...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suematsu F,Minemoto M,Yukawa E,Higuchi S

更新日期：1999-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Lorenzo-Pinto A,Giménez-Manzorro Á,Rodríguez-González CG,Ahumada-Jiménez A,Herranz-Alonso A,Marzal-Alfaro MB,Sanjurjo-Sáez M

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lee DG,Chae H,Yim DS,Park SH,Choi SM,Kim S,Choi JH,Yoo JH,Shin WS

更新日期：2009-06-01 00:00:00

abstract：:Standard meta-analytical and pharmacoeconomic techniques were used to study the clinical effectiveness and the cost-effectiveness ratio of the prophylactic (or pre-emptive) administration of G-CSF to patients with small cell lung cancer treated with conventional myelosuppressive cytotoxic chemotherapy. In the first pa...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Messori A,Trippoli S,Tendi E

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Patients' own medications (POM) are medications that patients have obtained in the community setting and bring to the hospital when admitted. The practice of using POMs has not been well studied. OBJECTIVE:To identify benefits, risks and other impacts on the use of POM in hospitals. METHODS:A systematic se...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lummis H,Sketris I,Veldhuyzen van Zanten S

更新日期：2006-12-01 00:00:00

abstract：WHAT IS KNOW AND OBJECTIVE:Teriflunomide is indicated for the treatment of adult patients with relapsing-remitting multiple sclerosis. CASE SUMMARY:We present a rare intoxication with a high dose (672 mg) of teriflunomide. According to its product label, the only known treatment is the administration of colestyramine ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mian P,van Haaften WT,Assink M,van Drie-Pierik RJHM

更新日期：2021-01-09 00:00:00

abstract：OBJECTIVE:To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data. METHOD:The steady-state blood level data (n = 129) after repetitive oral administration in 71 hospitalized neonates were analysed using Nonlinear Mixed Effects Modellin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yukawa E,Akiyama K,Suematsu F,Yukawa M,Minemoto M

更新日期：2007-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Thiopurines are cornerstone drugs in the treatment of acute lymphoblastic leukaemia (ALL), but their use can be complicated by the incidence of life-threatening leucopenia. CASE DESCRIPTION:We describe a case of a 6-year-old Chinese boy with B-ALL receiving extremely low dose of 6-mercapto...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhai XY,Zhou Y,Dong L,Nie AQ,Zhi LJ,Jacqz-Aigrain E,Wang TY,Wang L,Zhao W

更新日期：2021-02-01 00:00:00

abstract：:Midazolam concentration curves versus time were analysed in 10 otherwise healthy patients (ASA I-II) with inferior limb pathologies. The benzodiazepine was used as an adjuvant agent to epidural anaesthesia in view of its lower residual effect compared with other intravenous benzodiazepines. Midazolam pharmacokinetics...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sánchez-Alcaraz A,Sangrador G,Laguarda M,Quintana B

更新日期：1991-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Carvedilol is the standard of care for heart failure (HF) patients. Carvedilol is partially metabolized by the highly polymorphic enzyme, CYP2D6. To reach an effective dose while avoiding adverse drug reactions (ADRs), testing of CYP2D6 genotype prior to carvedilol initiation may be consider...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shihmanter R,Nulman I,Goland S,Caspi A,Bar-Haim A,Harary I,Berkovitch M,Arcavi L

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:A large number of structurally and functionally diverse compounds act as substrates or modulators of p-glycoprotein (p-gp). Some of them possess multiple drug resistance (MDR)-reversing activity, but only a small number of them have entered clinical study. In order to uncover the factors which exert a signifi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang RB,Kuo CL,Lien LL,Lien EJ

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF). AIM:To evaluate the effects of a macrolide antibio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yalçin E,Kiper N,Ozçelik U,Doğru D,Firat P,Sahin A,Ariyürek M,Mocan G,Gürcan N,Göçmen A

更新日期：2006-02-01 00:00:00