Stability of vancomycin in plastic syringes measured by high-performance liquid chromatography.

Abstract:

:The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickinson Plastipak (three-piece) and B. Braun Medical Injekt (two-piece)). In sodium chloride solution (0.9%; pH 5.4) it was stable for 62 and 34 days, while in dextrose solution (5%; pH 4.2) it was stable for 55 and 33 days, respectively, at the same temperature. At 4 degrees C vancomycin was stable in all three infusion fluids and both types of syringe for at least 84 days.

journal_name

J Clin Pharm Ther

authors

Wood MJ,Lund R,Beavan M

doi

10.1111/j.1365-2710.1995.tb00705.x

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

319-25

issue

6

eissn

0269-4727

issn

1365-2710

journal_volume

20

pub_type

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