Abstract:
BACKGROUND:Various methods of detecting cancer with fluorescence have been developed. One type of fluorescence is based on the tumor-localizing properties of certain dyes. However, the phototoxicity of most known tumor-localizing dyes hinders the safe use of such diagnostic methods. The authors have developed a fluorescence imaging system to detect the distribution of a nontoxic dye, fluorescein, and they have evaluated the feasibility of the system by using it to detect oral dysplastic lesions in hamsters. METHODS:Dysplasia was induced in the cheek pouches of hamsters by application of the carcinogen 9,10-dimethyl-1,2-benzantracene. Fluorescein was administered to the hamsters either intravenously or orally before the fluorescence examination. The endoscopic fluorescence system produced dye-distribution images of both treated and control pouches. Two fluorescence images in different spectral regions were processed for each dye image. Biopsy material from both pouches was examined histopathologically. RESULTS:The accumulation of fluorescein was detected in 22 of 23 specimens containing dysplastic lesions. CONCLUSIONS:These results demonstrate the utility of this fluorescein accumulation method in the detection of dysplasia. The accumulation of fluorescein in dysplastic lesions may point to acidification of interstitial medium in such lesions.
journal_name
Cancerjournal_title
Cancerauthors
Lazarev VV,Roth RA,Kazakevich Y,Hang Jdoi
10.1002/(sici)1097-0142(19990401)85:7<1421::aid-cnsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
1421-9issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19990401)85:7<1421::AID-CNjournal_volume
85pub_type
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