Abstract:
:The family of interferon regulatory transcription factors (IRF) participates in the virus-induced and dsRNA-stimulated transcriptional regulation of either type I IFN genes or a definite set of genes which can also be activated by IFN. In this review, we place emphasis on the role of IRF-3 that associates with the coactivators CBP and/or p300, together or not with IRF-7. These complexes bind to the PRDI, PRDI-like domains or to a number of ISRE sequences located in the promoter of these virus-inducible genes. We also discuss the involvement of the IRF-3-related complexes in the differential regulation of IFN-A genes.
journal_name
Biochimiejournal_title
Biochimieauthors
Bragança J,Civas Adoi
10.1016/s0300-9084(99)80021-2subject
Has Abstractpub_date
1998-08-01 00:00:00pages
673-87issue
8-9eissn
0300-9084issn
1638-6183pii
S0300-9084(99)80021-2journal_volume
80pub_type
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