Abstract：
:Epigenetic mechanisms are likely to play a role in many complex diseases, the extent of which we only beginning to understand. COPD and asthma are two respiratory diseases subject to strong environmental influences depending on underlying genetic susceptibility. Epigenetic mechanisms such as DNA methylation, histone modification and microRNA may be involved in these processes by modulating environmental effects to influence disease development. Given their demonstrated modifiable nature, epigenetic mechanisms may open new possibilities for therapeutic intervention. Here we give an overview of recent developments in the field of respiratory epigenetics in relation to asthma and COPD in the context of our current understanding of mechanisms leading to such diseases.
journal_name
Biochimiejournal_title
Biochimieauthors
Kabesch M,Adcock IMdoi
10.1016/j.biochi.2012.07.017subject
Has Abstractpub_date
2012-11-01 00:00:00pages
2231-41issue
11eissn
0300-9084issn
1638-6183pii
S0300-9084(12)00299-4journal_volume
94pub_type
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