Abstract：
:DNA mismatch repair (MMR) is an important replication error avoidance mechanism that prevents mutation. The association of defective MMR with familial and sporadic gastrointestinal and endometrial cancer has been acknowledged for some years. More recently, it has become apparent that MMR defects are common in acute myeloid leukaemia/myelodysplastic syndrome (AML/MDS) that follows successful chemotherapy for a primary malignancy. Therapy-related haematological malignancies are often associated with treatment with alkylating agents. Their frequency is increasing and they now account for at least 10% of all AML cases. There is also evidence for an association between MMR deficient AML/MDS and immunosuppressive treatment with thiopurine drugs. Here we review how MMR interacts with alkylating agent and thiopurine-induced DNA damage and suggest possible ways in which MMR defects may arise in therapy-related AML/MDS.
journal_name
Biochimiejournal_title
Biochimieauthors
Karran P,Offman J,Bignami Mdoi
10.1016/j.biochi.2003.10.007keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1149-60issue
11eissn
0300-9084issn
1638-6183pii
S0300908403001834journal_volume
85pub_type
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