Abstract：
:Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.
journal_name
Biochimiejournal_title
Biochimieauthors
Wang J,Kolko Mdoi
10.1016/j.biochi.2010.04.007subject
Has Abstractpub_date
2010-06-01 00:00:00pages
611-9issue
6eissn
0300-9084issn
1638-6183pii
S0300-9084(10)00145-8journal_volume
92pub_type
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