Iron repressibility of siderophore and transferrin-binding protein in Staphylococcus aureus.

Abstract:

:In order to investigate whether the iron acquisition mechanisms of Staphylococcus aureus are induced by iron restriction in vitro, we examined S. aureus ATCC 6538 for production of siderophore and expression of transferrin-binding protein (SA-tbp) in normal or deferrated brain heart infusion broth (BHI). Siderophore production was earlier and greater in the deferrated BHI. The SA-tbp, detected by ligand blot assay, was expressed only in the deferrated BHI. When human transferrin was added to the deferrated BHI, siderophore production was later and lower than when transferrin was not present. In conclusion, both iron acquisition mechanisms of S. aureus were found to be iron-repressible and via both of them, human transferrin-bound iron was utilized for growth under iron-restricted condition.

journal_name

FEMS Microbiol Lett

authors

Lim Y,Shin SH,Lee SI,Kim IS,Rhee JH

doi

10.1111/j.1574-6968.1998.tb13020.x

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

19-24

issue

1

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(98)00143-8

journal_volume

163

pub_type

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