Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum.

Abstract:

:When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 micrograms/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10(-6) M), but was abolished by the addition of papaverine (10(-4) M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.

journal_name

FEMS Microbiol Lett

authors

Hitotsubashi S,Akagi M,Saitou A,Yamanaka H,Fujii Y,Okamoto K

doi

10.1016/0378-1097(92)90655-8

keywords:

subject

Has Abstract

pub_date

1992-01-15 00:00:00

pages

249-52

issue

3

eissn

0378-1097

issn

1574-6968

journal_volume

69

pub_type

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